Drug & supplement interaction

Ip-6 + Leucovorin Calcium

Leucovorin Calcium brand name: Wellcovorin.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ip-6 and Leucovorin Calcium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Ip-6 and Leucovorin Calcium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Leucovorin Calcium and Ip-6 in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ip-6 safety at a glance

Ip-6 overall Use caution Generally considered low-risk in food amounts, but supplement safety is not well studied and it can reduce absorption of minerals.
Pregnancy Likely Safe When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of IP-6 when used in amounts greater tha... Read the full pregnancy detail
Breastfeeding Likely Safe When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of IP-6 when used in amounts greater tha... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Leucovorin Calcium and Ip-6? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Leucovorin Calcium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Leucovorin Calcium is filed under a single classification — oral drugs. Ip-6 has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Leucovorin Calcium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ip-6 Does Interact With Other Medications

Ip-6 has 122 moderate known drug interactions in our database — Leucovorin Calcium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Leucovorin Calcium)
Taking anything else?

Check Another of Your Medications Against Ip-6

Covers the 2,830 medications we’ve checked against Ip-6. Pick one to open its full report.

What to actually watch for

What Leucovorin Calcium’s Own FDA Label Lists

This is not an interaction — none of it involves Ip-6. These are the most notable effects listed in the ADVERSE REACTIONS section of Leucovorin Calcium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • A low white blood cell count Worth acting on mentioned in 5.8% of FDA reports for Leucovorin Calcium
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Hives Worth acting on
  • A higher chance of infection Worth acting on
  • Mouth irritation or sores
  • Hair loss
  • Reduced appetite
  • Constipation
  • Diarrhea mentioned in 9.5% of FDA reports for Leucovorin Calcium

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Leucovorin Calcium. Read the label on DailyMed › Where a percentage is shown, it is the share of 19,003 voluntary FDA FAERS reports for Leucovorin Calcium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Ip-6’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ip-6 side to compare — that is a limit of the record, not a statement that Ip-6 has no side effects.

Special populations

Ip-6 in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of IP-6 when used in amounts greater than those found in foods; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Leucovorin Calcium

This page covers Ip-6 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Leucovorin Calcium page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Leucovorin Calcium interaction page

One more smart check

Taking Ip-6 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 189 real supplement products containing Ip-6, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ip-6. Even though Ip-6 itself has no known interaction with Leucovorin Calcium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ip-6 and Leucovorin Calcium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ip-6
Top 25%

#312 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Leucovorin Calcium
Top 25%

#537 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ip-6 reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ip-6 and Leucovorin Calcium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ip-6

What is Ip-6?

  • Antioxidant support
  • Cancer prevention interest
  • Kidney stone prevention
  • Heart and immune support
  • Reducing excess iron

IP-6 (inositol hexaphosphate, also called phytic acid or phytate) is a natural compound found in high-fiber plant foods and sold as a supplement, often paired with inositol. It is most studied as an antioxidant and mineral binder, but human evidence for its popular uses—such as cancer prevention—is limited and not conclusive. Talk to your pharmacist or doctor before using it, especially if you have low mineral levels or a chronic condition.

Naturally found in whole grains, legumes, nuts, and seeds; supplements are usually made from rice bran or corn · Capsules, tablets, powders (often combined with inositol)

An interaction check asks whether these two react with each other — it does not ask whether Ip-6 is a good idea for someone in your situation. Here is what our Ip-6 record says about it on its own.

Ip-6: dosing

There is no officially established or standardized dose for IP-6 supplements. Products vary widely, and many combine IP-6 with inositol.The best approach is to follow the directions on the product label and not exceed them.

From our Ip-6 monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ip-6 monograph & all interactions
Medication

About Leucovorin

What Is Leucovorin Used For?

Brand name: Wellcovorin

Leucovorin is used to reduce the harmful effects of methotrexate when the body is slow to clear it, and to counteract accidental overdoses of drugs that block folic acid (called folic acid antagonists or DHFR inhibitors). It is also used to treat cerebral folate transport deficiency (FOLR1-CFTD), a rare genetic condition that prevents the brain from receiving enough folate.

The injectable forms — including leucovorin calcium injection and Vykoura — are additionally approved for rescue after high-dose methotrexate therapy, for treatment of megaloblastic anemia (a type of anemia caused by low folic acid) when oral treatment isn't possible, and for use alongside fluorouracil in treating metastatic colorectal cancer. Leucovorin calcium injection is specifically indicated for rescue after high-dose methotrexate in osteosarcoma.

Most-Reported Side Effects for Leucovorin Calcium

From FAERS, the FDA’s public side-effect reporting system (19,003 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 1,799 reports
Nausea 1,388 reports
Vomiting 1,135 reports
Neutropenia 1,094 reports
Fever 1,011 reports
See full Leucovorin drug information
Keep checking

Other Drugs & Ip-6

Browse every other medication we’ve checked against Ip-6 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Ip-6 page.

No interaction 2,707 drugs checked — show the list

We also checked Ip-6 against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Ip-6 list.

See the full Ip-6 interactions page
See every supplement checked against Leucovorin Calcium, ranked by severity
Evidence & sources

Ip-6 References

The 3 references that drive our Ip-6 monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 1996;96:1027-39. PubMed
  2. Vucenik I, Podczasy JJ, Shamsuddin AM. Antiplatelet activity of inositol hexaphosphate. Anticancer Res 1999;19:3689-93.
  3. Ikenaga T, Kakumoto K, Kohda N, Yamamoto T. Effect of Inositol Hexaphosphate (IP6) on Serum Uric Acid in Hyperuricemic Subjects: a Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Plant Foods Hum Nutr. 2019 Sep;74(3):316-321. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ip-6 and Leucovorin Calcium Together: Common Questions

Is it safe to take Ip-6 with Leucovorin Calcium?
We do not list a known interaction between Ip-6 and Leucovorin Calcium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Ip-6 and Leucovorin Calcium combination checked?
Interactions in our licensed database are recorded against drug classes. Leucovorin Calcium is filed under 1 classification, and Ip-6 has documented interactions with 1 drug class — none of Leucovorin Calcium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ip-6 interact with any other medications?
Yes. Ip-6 has 122 documented drug interactions in our database — Leucovorin Calcium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Leucovorin Calcium interact with any supplements?
Yes. Leucovorin Calcium has documented interactions with 17 supplements in our database — Ip-6 is not one of them. The Leucovorin Calcium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ip-6 monograph Uses, safety profile, and every drug interaction in one place Leucovorin drug information The full plain-English guide to this medication Leucovorin Calcium supplement interactions Every supplement checked against Leucovorin Calcium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Leucovorin Calcium and Ip-6?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.