Drug & supplement interaction

Picrorhiza + Ceftriaxone

Ceftriaxone brand name: Rocephin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Picrorhiza and Ceftriaxone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Picrorhiza and Ceftriaxone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ceftriaxone and Picrorhiza in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Picrorhiza safety at a glance

Picrorhiza overall Use caution Generally used in traditional medicine, but human safety data are limited, so use with care.
Pregnancy Avoid Not enough safety information; avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ceftriaxone and Picrorhiza? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ceftriaxone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ceftriaxone is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Picrorhiza has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Ceftriaxone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Picrorhiza Does Interact With Other Medications

Picrorhiza has 207 moderate known drug interactions in our database — Ceftriaxone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Ceftriaxone)
Taking anything else?

Check Another of Your Medications Against Picrorhiza

Covers the 2,830 medications we’ve checked against Picrorhiza. Pick one to open its full report.

What to actually watch for

What Picrorhiza Itself Has Been Linked To

This is not an interaction — nothing below involves Ceftriaxone. It is the side-effect record for Picrorhiza on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Picrorhiza, this list is the first place to look.

  • Reduced appetite / Diarrhea / Vomiting Additional detail

    “Orally, picrorhiza may cause vomiting, rash, anorexia, diarrhea, itching, and giddiness.”

    Picrorhiza · Natural Medicines adverse-effect record, reported in anorexia.

    1 source cited
    1. 11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.

    “Orally, picrorhiza may cause vomiting, anorexia, and diarrhea.”

    Picrorhiza · Natural Medicines adverse-effect record, reported in anorexia.

    1 source cited
    1. 11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
  • Itching / A skin rash Additional detail

    “Orally, picrorhiza may cause rash and itching.”

    Picrorhiza · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.

Everything above comes from the Natural Medicines adverse-effect record for Picrorhiza — expand a row for the licensed statement it rests on. We haven’t matched Ceftriaxone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Ceftriaxone.

Everything else you take

See Every Supplement That Interacts With Ceftriaxone

This page covers Picrorhiza only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ceftriaxone page lists 44 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Calcium (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 39 moderate · 2 minor.

From our pharmacist’s overview on the Ceftriaxone page

“Kidney strain is the risk to understand first on this page. Ceftriaxone (Rocephin) is an injectable antibiotic used for serious infections, and three of the 44 supplements on file carry major ratings, two of them because they can harm the kidneys on their own: Siberian cocklebur and asarabacca, which is often contaminated with kidney-d…”

Reviewed by 2 · Jul 18, 2026

Open the Ceftriaxone interaction page

One more smart check

Taking Picrorhiza as Part of a Dietary Supplement Product? Check It for Interactions

We hold 177 real supplement products containing Picrorhiza, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Picrorhiza. Even though Picrorhiza itself has no known interaction with Ceftriaxone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Picrorhiza and Ceftriaxone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Picrorhiza
Top half

#604 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ceftriaxone
Top half

#1,136 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Picrorhiza reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Picrorhiza and Ceftriaxone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Picrorhiza

What is Picrorhiza?

  • Liver support
  • Digestive complaints
  • Asthma and breathing problems
  • Skin conditions
  • Fever
  • Immune support

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-protective and anti-inflammatory effects, but high-quality evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Picrorhiza kurroa · Plantaginaceae · Roots and rhizomes · Capsules, tablets, powder (churna), liquid extracts, and traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Picrorhiza is a good idea for someone in your situation. Here is what our Picrorhiza record says about it on its own.

Picrorhiza: dosing

There is no well-established standard dose of Picrorhiza. The amount used can vary widely depending on the form (powder, capsule, or extract) and how concentrated the product is.The safest approach is to follow the dosing directions on the product label and not to exceed them.

From our Picrorhiza monograph — the full record covers uses, side effects and every documented interaction.

Read the full Picrorhiza monograph & all interactions
Medication

About Ceftriaxone Injection

What Is Ceftriaxone Injection Used For?

Brand name: Rocephin

Ceftriaxone Injection is used to treat bacterial infections in many parts of the body, including the lungs (lower respiratory tract infections), urinary tract, skin, bones and joints, abdomen, and bloodstream (septicemia). It also treats bacterial meningitis (infection of the lining around the brain and spinal cord), pelvic inflammatory disease, acute bacterial ear infections (otitis media), and gonorrhea.

In addition, a single dose of ceftriaxone may be given before certain surgeries — such as hysterectomy, gallbladder surgery, or coronary artery bypass surgery — to help prevent postoperative infection. It works only against bacterial infections; it will not treat viral illnesses like the flu or a cold.

Most-Reported Side Effects for Ceftriaxone

From FAERS, the FDA’s public side-effect reporting system (38,242 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 2,054 reports
Acute kidney injury 1,826 reports
Dyspnea 1,592 reports
Pneumonia 1,338 reports
Vomiting 1,265 reports
See full Ceftriaxone Injection drug information
Keep checking

Other Drugs & Picrorhiza

Browse every other medication we’ve checked against Picrorhiza — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Picrorhiza page.

No interaction 2,622 drugs checked — show the list

We also checked Picrorhiza against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Picrorhiza list.

See the full Picrorhiza interactions page
See every supplement checked against Ceftriaxone, ranked by severity
Evidence & sources

Picrorhiza References

The 7 references that drive our Picrorhiza monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
  2. Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
  3. Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
  4. Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
  5. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
  6. Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
  7. Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Picrorhiza and Ceftriaxone Together: Common Questions

Is it safe to take Picrorhiza with Ceftriaxone?
We do not list a known interaction between Picrorhiza and Ceftriaxone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Picrorhiza and Ceftriaxone combination checked?
Interactions in our licensed database are recorded against drug classes. Ceftriaxone is filed under 6 classifications, and Picrorhiza has documented interactions with 2 drug classes — none of Ceftriaxone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Picrorhiza interact with any other medications?
Yes. Picrorhiza has 207 documented drug interactions in our database — Ceftriaxone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ceftriaxone interact with any supplements?
Yes. Ceftriaxone has documented interactions with 44 supplements in our database — Picrorhiza is not one of them. The Ceftriaxone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Picrorhiza monograph Uses, safety profile, and every drug interaction in one place Ceftriaxone Injection drug information The full plain-English guide to this medication Ceftriaxone supplement interactions Every supplement checked against Ceftriaxone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ceftriaxone and Picrorhiza?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.