Drug & supplement interaction

Pregnenolone + Captopril

Captopril brand names: Capoten, Acepril.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pregnenolone and Captopril in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Pregnenolone and Captopril

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Captopril and Pregnenolone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pregnenolone safety at a glance

Pregnenolone overall Use caution It is a hormone with limited human safety data, so use only under guidance from a healthcare professional.
Pregnancy Avoid Hormone supplements should be avoided during pregnancy due to unknown risks.
Breastfeeding Avoid Not enough safety information exists, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Captopril and Pregnenolone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Captopril

Interactions in our licensed database are recorded against drug classes, not just single drug names. Captopril is filed under 5 classifications — including ace inhibitors (aceis), antihypertensive drugs, photosensitizing drugs. Pregnenolone has documented interactions with 5 drug classes — the most serious being benzodiazepines (moderate), estrogens (moderate) and progesterone (moderate) — and none of Captopril’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pregnenolone Does Interact With Other Medications

Pregnenolone has 82 moderate known drug interactions in our database — Captopril isn’t one of them. If you take anything else, check it against the full list below.

Moderate 82 No known interaction 2,748 (incl. Captopril)
Taking anything else?

Check Another of Your Medications Against Pregnenolone

Covers the 2,830 medications we’ve checked against Pregnenolone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pregnenolone and Captopril May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Sun sensitivity / A skin rash Additional detail

    Pregnenolone

    “Orally, pregnenolone has been reported to cause skin abscesses, acne, and hair loss. A case of skin rash accompanied by a burning sensation on the back and sides of the hands has also been reported with oral pregnenolone use, possibly related to a photosensitivity reaction. The rash cleared on its own.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in acne.

    2 sources cited
    1. 94027. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
    2. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed ›

  • Hair loss Additional detail

    Pregnenolone

    “Orally, pregnenolone is generally well tolerated.

    Most Common Adverse Effects:

    Orally: Acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, tremor.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in acne.

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed ›

  • Drowsiness Additional detail

    Pregnenolone

    “Orally, pregnenolone has been reported to cause restlessness, tiredness, sweating, and a case of cold extremities. Sleep problems, drowsiness, and tremor have also been reported; however, it not certain if these effects were due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in common cold.

    3 sources cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
    2. 94032. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed
    3. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Pregnenolone

    “Orally, pregnenolone has been reported to cause depressive affect and increased appetite. Increased excitement, agitation, increased motor activity, and anorexia have also been reported; however, it is not certain if these effects were due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in anorexia.

    2 sources cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
    2. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed ›

  • Reduced appetite Additional detail

    Pregnenolone

    Recorded for Pregnenolone in the same Natural Medicines adverse-effect record shown under Anxiety or restlessness above.

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed ›

  • Muscle pain Additional detail

    Pregnenolone

    “A case of muscle pain/stiffness has been reported after oral use of pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in pain.

    1 source cited
    1. 94032. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed ›

  • Constipation Additional detail

    Pregnenolone

    “Orally, pregnenolone may cause diarrhea. Constipation has also been reported after oral use; however, it is not certain if this effect was due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed ›

  • Tiredness reported in 4.4% of FDA reports for Captopril Additional detail

    Pregnenolone

    Recorded for Pregnenolone in the same Natural Medicines adverse-effect record shown under Drowsiness above.

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Diarrhea reported in 4.9% of FDA reports for Captopril Additional detail

    Pregnenolone

    Recorded for Pregnenolone in the same Natural Medicines adverse-effect record shown under Hair loss above.

    Captopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Captopril, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Pregnenolone but not commonly for Captopril: increased appetite, sweating, tremor or shakiness and acne.

Effects for Captopril come from the ADVERSE REACTIONS section of its FDA label; effects for Pregnenolone come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 9,625 voluntary FDA FAERS reports for Captopril that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Pregnenolone or Captopril

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pregnenolone or Captopril, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Captopril

This page covers Pregnenolone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Captopril page lists 166 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Siberian Cocklebur (major).

By severity: 6 major · 136 moderate · 24 minor.

From our pharmacist’s overview on the Captopril page

“Anyone taking captopril (Capoten), an ACE inhibitor for high blood pressure and heart failure, should treat this list with genuine care rather than a quick skim. Most of the ingredients here act on blood pressure itself, some dropping it lower than intended and others, tyramine among them, pushing it back up and working against the med…”

Reviewed by 2 · Jul 18, 2026

Open the Captopril interaction page

One more smart check

Taking Pregnenolone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 303 real supplement products containing Pregnenolone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pregnenolone. Even though Pregnenolone itself has no known interaction with Captopril, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pregnenolone and Captopril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pregnenolone
Top half

#430 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Captopril
Steady interest

#1,576 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pregnenolone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pregnenolone and Captopril records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pregnenolone

What is Pregnenolone?

Pregnenolone
  • Memory and cognitive support
  • Anxiety and stress
  • Anti-aging
  • Fatigue and low energy
  • Mood support

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and anti-aging, but solid human evidence for these uses is very limited. Because it is a hormone, talk with your pharmacist or doctor before using it.

Naturally produced in the body; supplements are made synthetically (often from plant sterols like those in soy or wild yam) · Capsules, tablets, sublingual tablets, creams

An interaction check asks whether these two react with each other — it does not ask whether Pregnenolone is a good idea for someone in your situation. Here is what our Pregnenolone record says about it on its own.

Pregnenolone: dosing

There is no well-established or officially recommended dose for pregnenolone. Products vary widely in strength and form, and "more" is not safer with a hormone supplement.If your healthcare provider agrees you should try it, follow the directions on the product label and use the lowest amount that seems reasonable. Do not assume a higher dose works better.

From our Pregnenolone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pregnenolone monograph & all interactions
Medication

About Captopril

What Is Captopril Used For?

Brand names: Capoten, Acepril

Captopril tablets are used to treat high blood pressure (hypertension), heart failure, and left ventricular dysfunction (weakened pumping function of the heart) in stable patients after a heart attack. For the heart attack indication, it helps improve survival and reduces the chance of developing full heart failure.

Captopril tablets are also used to slow the progression of diabetic nephropathy (kidney damage caused by diabetes) in people with type 1 (insulin-dependent) diabetes who have retinopathy and significant protein in their urine. It reduces the risk of the kidneys failing to the point of needing dialysis or a transplant.

Most-Reported Side Effects for Captopril

From FAERS, the FDA’s public side-effect reporting system (9,625 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 615 reports
Hypertension 536 reports
Nausea 508 reports
Diarrhea 470 reports
Dizziness 448 reports
See full Captopril drug information
Keep checking

Other Drugs & Pregnenolone

Browse every other medication we’ve checked against Pregnenolone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
82Moderate
0Minor
2,747No known interaction
82 Moderate 2,747 No interaction
Moderate

82 interactions

Showing 60 of 82 moderate interactions — see all 82 on the Pregnenolone page.

No interaction 2,747 drugs checked — show the list

We also checked Pregnenolone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,747 medications checked with no known interaction — see the full Pregnenolone list.

See the full Pregnenolone interactions page
See every supplement checked against Captopril, ranked by severity
Evidence & sources

Pregnenolone References

The 6 references that drive our Pregnenolone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pregnenolone and Captopril Together: Common Questions

Is it safe to take Pregnenolone with Captopril?
We do not list a known interaction between Pregnenolone and Captopril. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pregnenolone and Captopril have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Pregnenolone and Captopril combination checked?
Interactions in our licensed database are recorded against drug classes. Captopril is filed under 5 classifications, and Pregnenolone has documented interactions with 5 drug classes — none of Captopril's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pregnenolone interact with any other medications?
Yes. Pregnenolone has 82 documented drug interactions in our database — Captopril is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Captopril interact with any supplements?
Yes. Captopril has documented interactions with 166 supplements in our database — Pregnenolone is not one of them. The Captopril interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pregnenolone monograph Uses, safety profile, and every drug interaction in one place Captopril drug information The full plain-English guide to this medication Captopril supplement interactions Every supplement checked against Captopril, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Captopril and Pregnenolone?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.