Thunder God Vine + Benzhydrocodone, Acetaminophen
Benzhydrocodone, Acetaminophen brand name: Apadaz.
Benzhydrocodone, Acetaminophen falls into 2 drug categories that Thunder God Vine can interact with; the most serious is rated moderate. Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.
Read the full interaction reportThunder God Vine and Benzhydrocodone, Acetaminophen
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Thunder God Vine interacts with whole categories of medication. Benzhydrocodone, Acetaminophen falls into 2 of those categories, so it can interact with Thunder God Vine in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 2Why this applies to Benzhydrocodone, Acetaminophen
Benzhydrocodone, Acetaminophen falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Thunder God Vine interacts with.
In vitro research shows that triptolide, a constituent of thunder god vine, inhibits CYP1A2 enzymes in human microsomes. This interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Apadaz (benzhydrocodone plus acetaminophen) and Thunder God Vine. In lab dish studies, a compound in this herb called triptolide seems to slow down a liver enzyme known as CYP1A2. If that enzyme is dialed back, drugs it helps clear could linger a bit longer in your system. In theory, that might nudge up opioid-type effects like drowsiness, dizziness, constipation, nausea, or slowed breathing.
That said, I want to be straight with you: this is theoretical only, based on test-tube work, and it has not actually been reported in people. Thunder God Vine also carries its own safety concerns and really should only be used under a doctor's watch. Please run this combo by your pharmacist or doctor before mixing the two.
- Song W, Liu M, Wu J, Zhai H, Chen Y, Peng Z. Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug. Curr Drug Metab. 2019;20(2):147-154. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 2Benzhydrocodone, Acetaminophen also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research shows that triptolide, a constituent of thunder god vine, inhibits CYP3A4 enzymes in human microsomes. This interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing about Apadaz: the benzhydrocodone part is actually a prodrug, meaning your body has to convert it into hydrocodone before it does much for pain. There's a wrinkle, though, because once it becomes hydrocodone, your liver's CYP3A4 enzyme helps break it down and clear it out. Thunder God Vine, at least in lab dish studies, may block that CYP3A4 enzyme.
If that blocking happened in real life, your opioid could hang around longer and build up, leading to stronger effects like heavy drowsiness, constipation, nausea, or slowed, shallow breathing. I want to be honest though: this is theoretical, based only on test-tube data, and has never been reported in people. Still, since opioids are nothing to gamble with, please check with your pharmacist or doctor before combining them.
- Song W, Liu M, Wu J, Zhai H, Chen Y, Peng Z. Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug. Curr Drug Metab. 2019;20(2):147-154. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Thunder God Vine Also Interacts With Other Medications
Thunder God Vine has 850 moderate known drug interactions in our database — the Benzhydrocodone, Acetaminophen one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Thunder God Vine
We haven’t checked that one against Thunder God Vine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Thunder God Vine. Pick one to open its full report.
See Every Supplement That Interacts With Benzhydrocodone, Acetaminophen
This page covers Thunder God Vine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Benzhydrocodone, Acetaminophen page lists 299 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).
By severity: 14 major · 239 moderate · 46 minor.
Where Thunder God Vine and Benzhydrocodone, Acetaminophen Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,091 of 1,452 supplements looked up here in the last 7 days
#1,955 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Thunder God Vine
What is Thunder God Vine?
- Rheumatoid arthritis
- Lupus and autoimmune conditions
- Inflammation
- Skin conditions like psoriasis
- Immune-related disorders
Thunder God Vine is a Chinese herb studied mainly for rheumatoid arthritis and other autoimmune conditions, with some promising but limited evidence. It can be toxic if prepared or dosed improperly, and may cause serious side effects, so it should only be used under medical supervision. Avoid it during pregnancy and breastfeeding.
About Benzhydrocodone and Acetaminophen
What Is Benzhydrocodone and Acetaminophen Used For?
Brand name: Apadaz
Apadaz is indicated for the short-term management of acute pain — specifically pain severe enough to require an opioid analgesic and for which other treatments are inadequate. It is approved for use for no more than 14 days.
Apadaz is reserved for patients who have not been able to tolerate non-opioid pain relievers, or for whom those options have not provided adequate pain relief. It should not be used long-term unless pain remains severe and alternative treatments continue to be insufficient.
Other Drugs & Thunder God Vine
Browse every other medication we’ve checked against Thunder God Vine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
850 interactions
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Metronidazole ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Oxybutynin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Miconazole ›
- Acetaminophen ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Bendamustine ›
- Betamethasone ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Cimetidine ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Etoposide ›
Showing 60 of 850 moderate interactions — see all 850 on the Thunder God Vine page.
No interaction 1,979 drugs checked — show the list
We also checked Thunder God Vine against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Aspirin ›
- Metoprolol ›
- Levothyroxine, Liothyronine ›
- Tirzepatide ›
- Ibuprofen ›
- Isotretinoin ›
- Metformin ›
- Docusate ›
- Semaglutide ›
- Amphetamine ›
- Lisdexamfetamine ›
- Methamphetamine ›
- Sumatriptan ›
- Amoxicillin ›
- Lisinopril ›
- Valacyclovir ›
- Hydroxyurea ›
- Bupropion ›
- Methotrexate ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Acyclovir ›
- Duloxetine ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Acetylsalicylic Acid ›
- Insulin Degludec, Liraglutide ›
- Bisoprolol ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Aminophylline, Amobarbital, Ephedrine ›
- Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate ›
- Aspirin, Butalbital ›
- Atenolol, Chlorthalidone ›
- Enalapril Maleate ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ezetimibe ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Cephalexin ›
- Aspirin, Ethoheptazine, Meprobamate ›
- Ephedrine, Phenobarbital, Theophylline ›
- Rosiglitazone Maleate ›
- Sacubitril, Valsartan ›
- Canagliflozin, Metformin ›
- Insulin Aspart, Insulin Degludec ›
- Candesartan Cilexetil, Hydrochlorothiazide ›
- Levetiracetam ›
- Sulfamethoxazole, Trimethoprim ›
- Nebivolol Hydrochloride, Valsartan ›
- Daunorubicin, Cytarabine ›
- Atenolol ›
Showing the 60 most looked-up of 1,979 medications checked with no known interaction — see the full Thunder God Vine list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Benzhydrocodone, Acetaminophen Is Linked to Lower Levels of One Nutrient
Natural Medicines records Benzhydrocodone, Acetaminophen as a medicine that can lower these. This is not an interaction with Thunder God Vine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Benzhydrocodone, Acetaminophen nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Thunder God Vine and Benzhydrocodone, Acetaminophen Together: Common Questions
Can you take Thunder God Vine with Benzhydrocodone, Acetaminophen?
Why are there 2 interactions listed for Thunder God Vine and Benzhydrocodone, Acetaminophen?
How serious is the Thunder God Vine and Benzhydrocodone, Acetaminophen interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Benzhydrocodone, Acetaminophen and Thunder God Vine?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.