Drug & supplement interaction

Yerba Mansa + Sodium Phenylbutyrate

Sodium Phenylbutyrate brand names: Buphenyl, Pheburane, Olpruva.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Yerba Mansa and Sodium Phenylbutyrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Phenylbutyrate states a food rule worth keeping to.

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Interaction report

Yerba Mansa and Sodium Phenylbutyrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sodium Phenylbutyrate and Yerba Mansa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Yerba Mansa safety at a glance

Yerba Mansa overall Use caution Human safety data are limited, so use cautiously and discuss with a healthcare professional.
Pregnancy Avoid Not enough safety information is available, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sodium Phenylbutyrate and Yerba Mansa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sodium Phenylbutyrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Phenylbutyrate is filed under 2 classifications — sodium-containing drugs, oral drugs. Yerba Mansa has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Sodium Phenylbutyrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Yerba Mansa Does Interact With Other Medications

Yerba Mansa has 248 moderate known drug interactions in our database — Sodium Phenylbutyrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Sodium Phenylbutyrate)
Taking anything else?

Check Another of Your Medications Against Yerba Mansa

Covers the 2,830 medications we’ve checked against Yerba Mansa. Pick one to open its full report.

What to actually watch for

What Sodium Phenylbutyrate’s Own FDA Label Lists

This is not an interaction — none of it involves Yerba Mansa. These are the most notable effects listed in the ADVERSE REACTIONS section of Sodium Phenylbutyrate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Hearing loss Worth acting on
  • Memory problems Worth acting on
  • Bleeding in the gut Worth acting on
  • Low potassium Worth acting on
  • Pancreatitis Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on

Showing the 10 most notable of 28 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Sodium Phenylbutyrate. Read the label on DailyMed › Where a percentage is shown, it is the share of 411 voluntary FDA FAERS reports for Sodium Phenylbutyrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Yerba Mansa’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Yerba Mansa side to compare — that is a limit of the record, not a statement that Yerba Mansa has no side effects.

How to take them

Some Sodium Phenylbutyrate Products Have a Food Rule — Yerba Mansa Should Not Break It

At least one FDA label for a product containing Sodium Phenylbutyrate says to take it with food. If you take Yerba Mansa on an empty stomach out of habit, keep them separate — and take Sodium Phenylbutyrate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Phenylbutyrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

The powder is to be mixed with food (solid or liquid) for immediate use; however, when dissolved in water, BUPHENYL Powder has been shown to be stable for up to one week at room temperature or refrigerated.

From the Dosage and Administration section of the FDA label we read for Sodium Phenylbutyrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sodium Phenylbutyrate

This page covers Yerba Mansa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Phenylbutyrate page lists 19 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Sodium Phenylbutyrate page

“Sodium phenylbutyrate (Buphenyl, Pheburane, Olpruva) keeps ammonia in check in people with urea cycle disorders, so a supplement that blunts its absorption is not a small problem, it is the difference between a controlled ammonia level and a dangerous one. Seventeen of the 19 ingredients on this page, mostly fibers, gums, and mucilages…”

Reviewed by 2 · Jul 18, 2026

Open the Sodium Phenylbutyrate interaction page

One more smart check

Taking Yerba Mansa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 139 real supplement products containing Yerba Mansa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yerba Mansa. Even though Yerba Mansa itself has no known interaction with Sodium Phenylbutyrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Yerba Mansa and Sodium Phenylbutyrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yerba Mansa
Top half

#485 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sodium Phenylbutyrate
Steady interest

#2,720 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yerba Mansa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Yerba Mansa and Sodium Phenylbutyrate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Yerba Mansa

What is Yerba Mansa?

Yerba Mansa
  • Sore throat and respiratory congestion
  • Skin irritation and wounds
  • Mouth and gum inflammation
  • Urinary and digestive complaints
  • Antimicrobial support

Yerba mansa is a traditional Southwestern and Mexican medicinal plant used for sore throats, skin problems, and infections. Modern scientific evidence in humans is very limited, so its effectiveness is largely unproven. If you want to try it, talk to a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Anemopsis californica · Saururaceae · Root (rhizome) and leaves · Dried root, tea, tincture, capsules, powder, topical washes and salves

An interaction check asks whether these two react with each other — it does not ask whether Yerba Mansa is a good idea for someone in your situation. Here is what our Yerba Mansa record says about it on its own.

Yerba Mansa: dosing

There is no established, standardized dose for yerba mansa. Traditional use varied widely depending on whether it was prepared as a tea, tincture, or topical wash, and the strength of commercial products differs from brand to brand.If you choose to use a product, follow the directions on the label and do not exceed the suggested amount.

From our Yerba Mansa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Yerba Mansa monograph & all interactions
Keep checking

Other Drugs & Yerba Mansa

Browse every other medication we’ve checked against Yerba Mansa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Yerba Mansa page.

No interaction 2,581 drugs checked — show the list

We also checked Yerba Mansa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Yerba Mansa list.

See the full Yerba Mansa interactions page
See every supplement checked against Sodium Phenylbutyrate, ranked by severity
Evidence & sources

Yerba Mansa References

The 1 references that drive our Yerba Mansa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Yerba Mansa and Sodium Phenylbutyrate Together: Common Questions

Is it safe to take Yerba Mansa with Sodium Phenylbutyrate?
We do not list a known interaction between Yerba Mansa and Sodium Phenylbutyrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Yerba Mansa and Sodium Phenylbutyrate at the same time of day?
At least one FDA label for a product containing Sodium Phenylbutyrate says to take it with food. If you take Yerba Mansa on an empty stomach out of habit, keep them separate and take Sodium Phenylbutyrate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sodium Phenylbutyrate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Yerba Mansa and Sodium Phenylbutyrate combination checked?
Interactions in our licensed database are recorded against drug classes. Sodium Phenylbutyrate is filed under 2 classifications, and Yerba Mansa has documented interactions with 1 drug class — none of Sodium Phenylbutyrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Yerba Mansa interact with any other medications?
Yes. Yerba Mansa has 248 documented drug interactions in our database — Sodium Phenylbutyrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sodium Phenylbutyrate interact with any supplements?
Yes. Sodium Phenylbutyrate has documented interactions with 19 supplements in our database — Yerba Mansa is not one of them. The Sodium Phenylbutyrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Yerba Mansa monograph Uses, safety profile, and every drug interaction in one place Sodium Phenylbutyrate supplement interactions Every supplement checked against Sodium Phenylbutyrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.