Herb & supplement monograph

Siberian Cocklebur Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Siberian Cocklebur interacts with medications. The heart of this page is the interaction list — every drug Siberian Cocklebur is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Siberian Cocklebur is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Siberian Cocklebur Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of a serious Siberian Cocklebur drug interaction is high, and we advise most people taking prescription medications to avoid this supplement. Every interaction in this profile is rated major, and the most important ones are documented in humans, not just in the lab.

Interactions deserving the most attention

The clearest danger involves diabetes medications such as insulin, glyburide, and glimepiride: Siberian cocklebur has caused severe low blood sugar in people, often soon after it is taken, so this combination should not be used. It has also been linked to real cases of liver damage and even liver failure, which makes combining it with medications that can harm the liver, like atorvastatin or amiodarone, a genuine concern. Pairing it with medications that can strain the kidneys, such as cyclosporine or certain antibiotics, may add to kidney harm, though that risk is more theoretical.

What the rest of the list means

The list of interacting medications is long mainly because so many common drugs lower blood sugar or can affect the liver or kidneys. The concern here is not a long list of small theoretical issues; it reflects the plant's own documented toxicity, which is why every interaction carries a major rating.

Check your medications against Siberian Cocklebur

Based on HelloPharmacist’s Siberian Cocklebur interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Siberian Cocklebur

664 medications have a known interaction with Siberian Cocklebur, graded by severity. Select any drug for the full evidence-based detail.

664 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Siberian Cocklebur.

2,830 drugs
6-mercaptopurinePurinethol› Abacavir Sulfate, Dolutegravir, LamivudineTriumeq› Abacavir, LamivudineEpzicom› Abiraterone› Abiraterone AcetateYonsa, Zytiga› AcarboseGlucobay, Prandase, Precose› AcebutololRhotral, Sectral› AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Siberian Cocklebur combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Siberian Cocklebur affects

Every type of medication (drug category) Siberian Cocklebur is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Siberian Cocklebur interacts with
Antidiabetes DrugsHepatotoxic DrugsNephrotoxic Drugs
Antidiabetes Drugs

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans. Hypoglycemia occurs soon after consumption and worsens with time in most cases. Do not use Siberian cocklebur in people taking medications that also lower blood glucose.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Likely Evidence B
Hepatotoxic Drugs

Siberian cocklebur can adversely affect the liver. It has been linked to many cases of hepatotoxicity and some cases of liver failure. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Likelihood Likely Evidence B
Nephrotoxic Drugs

Siberian cocklebur can adversely affect the kidney. Theoretically, combining Siberian cocklebur with potentially nephrotoxic drugs might have additive harmful effects on kidney function.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Likelihood Likely Evidence B
Monograph

Siberian Cocklebur: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. Human evidence is very limited, and the plant contains naturally toxic compounds that can cause serious poisoning, so it should only be used under expert guidance, if at all.

Scientific name
Xanthium sibiricum
Family
Asteraceae
Part used
Fruit (burr), sometimes leaves and aerial parts
Common forms
Dried fruit, decoctions (teas), powders, capsules, traditional herbal formulas
People commonly use it for
  • Nasal congestion and sinus problems
  • Allergic rhinitis (hay fever)
  • Headache
  • Skin conditions and itching
  • Joint and muscle discomfort

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

The fruit contains toxic compounds and has caused serious poisoning, so it requires careful processing and professional oversight.

PregnancyLikely Unsafe

When the seeds and seedlings of Siberian cocklebur are used orally.

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When the seeds and seedlings of Siberian cocklebur are used orally.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Siberian cocklebur (Xanthium sibiricum) is a flowering plant in the daisy family (Asteraceae). It produces spiny, burr-like fruits that cling to clothing and animal fur. The plant grows widely across parts of Asia, including China, Korea, and Russia, often in fields, roadsides, and disturbed ground.

In traditional Chinese medicine and other Asian herbal systems, the dried fruit (sometimes called Cang Er Zi) is most often used. It is usually combined with other herbs in formulas and prepared as a decoction. People have traditionally used it to help with nasal stuffiness, sinus problems, and certain skin and joint complaints.

Uses & effectiveness

The most common traditional use of Siberian cocklebur is for nasal and sinus congestion, including allergic rhinitis (hay fever) and chronic sinus inflammation. It is also used in traditional practice for headaches, itchy skin conditions, and aches in the joints and muscles.

It is important to be honest about the evidence: high-quality human studies are very limited. Much of what is known comes from traditional use, laboratory experiments, and animal research. These early studies cannot prove that the herb is safe or effective in people. For most of its uses, there is not enough reliable evidence to say whether it works.

How it works

Siberian cocklebur contains a variety of natural compounds, including sesquiterpene lactones, glycosides, and other plant chemicals. Laboratory and animal studies suggest some of these may have anti-inflammatory or antimicrobial effects, which is the proposed basis for its use in sinus and allergy complaints.

The fruit also contains a toxic substance called carboxyatractyloside (and related compounds), which can harm the liver and other organs. Traditional processing is meant to reduce these toxins, but they remain a real safety concern. Keep in mind that most of these mechanisms come from laboratory or animal research, not from well-designed human trials.

Safety & precautions

Siberian cocklebur is not a low-risk herb. The raw or improperly prepared fruit, and especially the young seedlings, contain toxins that have caused serious and sometimes fatal poisoning. Reported effects of poisoning include liver damage, low blood sugar, nausea, vomiting, and harm to other organs.

Because of this, it should only be used when properly processed and under the guidance of a qualified, experienced practitioner. People with liver disease, children, older adults, and anyone with a chronic illness should be especially careful.

Pregnancy and breastfeeding: Avoid using Siberian cocklebur if you are pregnant or breastfeeding. There is not enough safety information, and the plant's toxic compounds make it a particular concern during these times. Always talk to a pharmacist or doctor before using it.

Side effects

Mild side effects can include nausea, stomach upset, vomiting, and dizziness. More serious problems are possible, especially with high doses or poorly processed products.

Serious risks include liver injury, low blood sugar, and toxic poisoning, which can be life-threatening. Seek medical care right away if someone develops severe vomiting, abdominal pain, confusion, yellowing of the skin or eyes, or signs of severe illness after taking this herb. People allergic to plants in the daisy family may also react to it.

Siberian Cocklebur: Reported Adverse Effects

Documented safety reports on Siberian Cocklebur from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Siberian cocklebur is generally regarded as unsafe for use. Any benefits of therapy might not outweigh the risk of toxicity. Orally, Siberian cocklebur seeds and seedlings can cause various adverse effects. Initial effects include abdominal pain, nausea, vomiting, hypoglycemia, elevated liver function tests, increased risk of bleeding, drowsiness, dizziness, dyspnea, sweating, fever, and palpitations. In some cases, symptoms have progressed to metabolic acidosis, worsening changes in blood sugar, arrhythmia, seizures, convulsions, coma, pancreatitis, hepatic failure, renal failure, myocardial and muscle injury, and death due to multi-organ failure. Fatal hepatic failure due to the Siberian cocklebur fruit has also been reported in a 20-month old child.

  1. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756.
  2. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
  3. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
  4. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639.
Reports by condition
Arrhythmia Cardiovascular

Orally, Siberian cocklebur seed can cause both tachycardia and bradycardia. Palpitations can occur in as little as 3 hours after ingestion, with arrhythmia occurring a few hours later. Elevated heart enzymes can also occur soon after intake. White blood cell infiltration in the myocardium has been reported in autopsy findings from patients who died after consuming Siberian cocklebur.

  1. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
  2. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
Bleeding Hematologic

Orally, Siberian cocklebur seedlings and seeds can increase the risk of bleeding, mainly due to hepatotoxic effects.

  1. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
Epilepsy Endocrine

Orally, Siberian cocklebur seedlings and seeds can cause hypoglycemia. This occurs soon after consumption. Later, metabolic acidosis, hyperglycemia, and/or worsening hypoglycemia might occur. In some individuals, these changes can cause seizures.

  1. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
  2. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
Epilepsy Neurologic/CNS

Orally, Siberian cocklebur seedlings and seeds can cause altered mental status, malaise, dizziness, sweating, fever, seizures, convulsions, unconsciousness, and coma. Malaise, dizziness, and sweating onset are rapid. Fever onset is usually after the onset of vomiting. Unconsciousness can follow vomiting within minutes or hours, with coma occurring later in some individuals. Microvascular hemorrhage in the brain has been reported in autopsy findings for patients who died after consuming Siberian cocklebur.

  1. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756.
  2. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
  3. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
Kidney failure Renal

Orally, Siberian cocklebur seedlings and seeds have resulted in cases of renal injury with increased levels of creatinine and blood urea nitrogen. This can result in decreased urine output. In some individuals, renal symptoms return to normal. However, renal failure can occur and renal proximal tubular necrosis has been reported in autopsy findings for patients who died after consuming Siberian cocklebur.

  1. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
  2. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
Liver transplant Hepatic

Orally, Siberian cocklebur seedlings and seeds can cause liver damage, including increased bilirubin levels and increases in liver enzyme levels by as much as 6 times the normal value. These symptoms can progress to include jaundice, hepatomegaly, and edema, resulting in liver failure and death in some patients. In one case, grade 3 encephalopathy and liver failure necessitated a liver transplant in a 15-year-old girl who had consumed approximately 80 Siberian cocklebur seeds.

The Siberian cocklebur fruit has also been reported to cause fatal hepatic failure in a 20-month old child who consumed Siberian cocklebur fruit over a 2-month period

  1. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756.
  2. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
  3. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
  4. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639.
Muscle breakdown Musculoskeletal

Orally, Siberian cocklebur seedlings and seeds can cause rhabdomyolysis. White blood cell infiltration in the muscles has been reported in autopsy findings from patients who died after consuming Siberian cocklebur.

  1. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
Nausea and vomiting Gastrointestinal

Orally, Siberian cocklebur seedlings and seeds can cause abdominal pain, nausea, and vomiting. Gastrointestinal symptoms occur within a few hours after consumption. In one case, pancreatitis occurred approximately 2 days after intake of the seeds in a 15-year-old girl.

  1. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
Poisoning Other

Orally, Siberian cocklebur can cause death associated with multi-organ failure. In some cases, death occurred less than 12 hours following intake. In one outbreak of illness related to consumption of Siberian cocklebur seedlings, death occurred in 25% of those affected. In another group of individuals with Siberian cocklebur seed poisoning, death occurred in three of nine of those affected. Death is more likely to occur in young children, especially those less than 15 years of age.

The quantity of Siberian cocklebur associated with death is not clear. In one illness outbreak, deaths were mainly in children and the seedlings were consumed in large quantities due to a food shortage. In another, children died after consuming an unknown quantity of seeds while working on a farm.

  1. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756.
  2. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established standardized dose for Siberian cocklebur, and dosing in traditional medicine depends on the specific preparation and formula used. Because of the toxicity risk, the difference between a traditional dose and a harmful one can be small.

Do not self-dose with this herb. If you are considering it, only use products from a reputable source and follow the directions of a qualified practitioner. Always check with your pharmacist or doctor first.

Pregnancy & Breastfeeding
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Siberian Cocklebur monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  2. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
  3. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  4. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Siberian Cocklebur

22 brands in our database make a supplement containing Siberian Cocklebur.

Product directory

Supplement products with Siberian Cocklebur

84 products in our database contain Siberian Cocklebur. Open any to see its full ingredient list and every drug interaction we check.

Guisazo de Caballo (Xantium Fructus) And Chancapiedra (Phylantus Niruri) Extract by Sunshine Naturals Capsule 90 Capsule(s) Off market View ingredients & interactions Nasal Tabs 2 by Health Concerns Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Nasal Tabs 2 by Health Concerns Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Nazanol by Metagenics Tablet Or Pill 30 Tablet(s) Off market View ingredients & interactions Pe Min Kan Wan by Plum Flower Tablet Or Pill 100 Pill(s) · 0.8 Oz(s) · 22 Gram(s) Off market View ingredients & interactions Pe Min Kan Wan by Plum Flower Tablet Or Pill 500 Pill(s) · 3.97 Oz(s) · 112.5 Gram(s) Off market View ingredients & interactions Pe Min Kan Wan by Plum Flower Tablet Or Pill 500 Pill(s) · 3.97 Oz(s) · 112.5 Gram(s) Off market View ingredients & interactions Pe Min Kan Wan by Plum Flower Tablet Or Pill 500 Pill(s) · 4.41 Ounce(s) · 125 Gram(s) Off market View ingredients & interactions Pe Min Kan Wan by Plum Flower Tablet Or Pill 100 Pill(s) · 0.88 Ounce(s) · 25 Gram(s) Off market View ingredients & interactions Sugar Coated Bi Yan Pian by Plum Flower Tablet Or Pill 120 Tablet(s) · 2 Oz(s) · 58 Gram(s) Off market View ingredients & interactions Upper Chamber Teapills (Cang Er Zi Wan) by Plum Flower Tablet Or Pill 1.2 oz. · 33 g · 200 Pill(s) Off market View ingredients & interactions Xanthium Relieve Surface by Health Concerns Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Siberian Cocklebur: Common Questions

Does Siberian Cocklebur interact with prescription medications?
Yes. We list 664 medications with a known interaction with Siberian Cocklebur, including 664 rated major. Use the checker above to see how Siberian Cocklebur interacts with a specific drug.
How are Siberian Cocklebur interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Siberian Cocklebur with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Siberian Cocklebur interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Siberian Cocklebur used for?
It is used in traditional Asian medicine mainly for nasal congestion, sinus problems, and allergies, and sometimes for headaches, skin itching, and joint aches. Strong human evidence for these uses is lacking.
Is Siberian Cocklebur safe to take?
It carries real safety concerns because the fruit and seedlings contain toxic compounds that have caused serious poisoning. It should only be used when properly processed and under the guidance of a qualified practitioner.
Can I use Siberian Cocklebur if I'm pregnant or breastfeeding?
No. It is best avoided during pregnancy and breastfeeding because of its potential toxicity and the lack of safety data.
What are the warning signs of cocklebur poisoning?
Watch for severe vomiting, stomach pain, dizziness, confusion, low blood sugar, or yellowing of the skin or eyes. Seek emergency medical care immediately if these occur.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Siberian Cocklebur

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See all 84 products with Siberian Cocklebur →
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