Medication interaction hub

What Supplements Interact with Amlodipine Besylate, Benazepril?

Amlodipine Besylate, Benazepril brand name: Lotrel. Every interaction below applies to the brands too.

257 Interactions 9 Major 203 Moderate 45 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amlodipine Besylate, Benazepril? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amlodipine Besylate, Benazepril against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit sits high on the worry list for anyone taking Lotrel (amlodipine besylate and benazepril), a two-in-one blood pressure pill. It blocks CYP3A4, the enzyme that clears amlodipine, so drug levels can climb, and it is one of nine major-rated interactions among the 257 supplement and herbal ingredients on file. I read this as a list that deserves real care. Most entries either deepen the pill's blood-pressure-lowering effect or push against it, and well over a hundred touch that same enzyme, with St. John's wort doing the opposite of grapefruit and speeding the drug's breakdown.

The remaining 203 moderate and 45 minor entries include one everyday item worth singling out: potassium. Benazepril makes the kidneys hold on to potassium, so potassium supplements can push blood levels too high, a state called hyperkalemia. Start with the nine major entries, then check the moderate ones against what you actually take.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 203 Minor 45 No known interaction 1,195

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amlodipine Besylate, Benazepril: Top Interactions at a Glance

The Amlodipine Besylate, Benazepril supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 257 interacting ingredients — plus 1,195 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Amlodipine Besylate, Benazepril Combinations Today

The Amlodipine Besylate, Benazepril + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Calcium + Amlodipine Besylate, Benazeprili

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Read the full interaction Moderate Likelihood Possible Magnesium + Amlodipine Besylate, Benazeprili

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.

Read the full interaction Moderate Likelihood Probable Fish Oil + Amlodipine Besylate, Benazeprili

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Sodium + Amlodipine Besylate, Benazeprili

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Amlodipine Besylate, Benazeprili

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Vitamin B6 + Amlodipine Besylate, Benazeprili

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Amlodipine Besylate, Benazepril

All 1,452 ingredients in our database, ranked by severity — 257 with a Amlodipine Besylate, Benazepril interaction on file and 1,195 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amlodipine Besylate, Benazepril?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Amlodipine Besylate, Benazepril?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Full Calcium + Amlodipine Besylate, Benazepril answer

Can you take Magnesium with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.

Full Magnesium + Amlodipine Besylate, Benazepril answer

Can you take Fish Oil with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Amlodipine Besylate, Benazepril answer

Can you take Sodium with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Amlodipine Besylate, Benazepril answer

Can you take Coenzyme Q10 with Amlodipine Besylate, Benazepril?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Amlodipine Besylate, Benazepril answer

Can you take Resveratrol with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Amlodipine Besylate, Benazepril answer

Can you take Rhodiola with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Full Rhodiola + Amlodipine Besylate, Benazepril answer

Can you take Rhubarb with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Amlodipine Besylate, Benazepril answer

Can you take Rice Protein with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE).

Full Rice Protein + Amlodipine Besylate, Benazepril answer

Can you take Rooibos with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Amlodipine Besylate, Benazepril answer

Can you take Royal Jelly with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.

Full Royal Jelly + Amlodipine Besylate, Benazepril answer

Can you take Rue with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Amlodipine Besylate, Benazepril answer

Can you take Saffron with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.

Full Saffron + Amlodipine Besylate, Benazepril answer

Can you take Sage with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase or decrease the effects of antihypertensive drugs.

Full Sage + Amlodipine Besylate, Benazepril answer

Can you take Schizonepeta with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Amlodipine Besylate, Benazepril answer

Can you take Sea Buckthorn with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Amlodipine Besylate, Benazepril answer

Can you take Slippery Elm with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Amlodipine Besylate, Benazepril answer

Can you take Soy with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Amlodipine Besylate, Benazepril answer

Can you take Sulforaphane with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Amlodipine Besylate, Benazepril answer

Can you take Sweet Annie with Amlodipine Besylate, Benazepril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Amlodipine Besylate, Benazepril answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amlodipine Besylate, Benazepril is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amlodipine Besylate, Benazepril, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amlodipine Besylate, Benazepril sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Amlodipine Besylate, Benazepril through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Amlodipine Besylate, Benazepril through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Amlodipine Besylate, Benazepril through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amlodipine Besylate, Benazepril through this category.

Ace Inhibitors (Aceis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Amlodipine Besylate, Benazepril through this category.

Calcium Channel Blockers 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Amlodipine Besylate, Benazepril through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amlodipine Besylate, Benazepril through this category.

Related: does Amlodipine Besylate, Benazepril deplete any nutrients?

Amlodipine Besylate, Benazepril has 2 reported nutrient associations in the research literature — see the Amlodipine Besylate, Benazepril nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Amlodipine Besylate, Benazepril

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amlodipine Besylate, Benazepril.

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Pharmacist Counseling Corner

Amlodipine Besylate, Benazepril & Supplements: Common Questions

What supplements interact with Amlodipine Besylate, Benazepril?
Our database currently documents 257 ingredients with a known Amlodipine Besylate, Benazepril interaction (9 major, 203 moderate, 45 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 257. The highest-ranked right now: American Hellebore, Grapefruit, Siberian Cocklebur.
Which Amlodipine Besylate, Benazepril supplement interactions are the most serious?
The 9 major-rated combinations — led by American Hellebore, Grapefruit, Siberian Cocklebur, Tyramine and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Amlodipine Besylate, Benazepril?
Plenty of supplements coexist fine with Amlodipine Besylate, Benazepril; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Lotrel have the same supplement interactions as Amlodipine Besylate, Benazepril?
Yes — Lotrel all contain Amlodipine Besylate, Benazepril, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Amlodipine Besylate, Benazepril deplete any vitamins or nutrients?
It might — Amlodipine Besylate, Benazepril has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Amlodipine Besylate, Benazepril nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Amlodipine Besylate, Benazepril and my other medications?
This page covers Amlodipine Besylate, Benazepril against supplements and herbal ingredients. Checking Amlodipine Besylate, Benazepril against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.