Medication interaction hub

What Supplements Interact with Apomorphine?

Apomorphine brand names: Uprima, Apokyn, APO-go, APO-go Pen, APO-go PFS, and others. Every interaction below applies to the brands too.

67 Interactions 2 Major 49 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Apomorphine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Apomorphine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Apomorphine is often used as a rescue treatment for sudden "off" episodes in Parkinson's disease, which makes a reliable dose worth protecting, and this is a list to read with real care rather than skim. Of the 67 supplements and herbs on file, two carry a major rating: St. John's wort, which speeds up the transporter that clears apomorphine and can blunt its effect, and activated charcoal, which can bind the drug and cut its levels no matter how it is given.

Most of the 49 moderate entries do quieter versions of the same thing, nudging how the body transports, absorbs, or breaks down the drug, and a small group of four may add to apomorphine's dopamine effect. The 16 minor entries carry the least weight; the two majors are where a rescue dose actually gets lost.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 49 Minor 16 No known interaction 1,385

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Apomorphine: Top Interactions at a Glance

The most significant Apomorphine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 67 interacting ingredients — plus 1,385 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Apomorphine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Apomorphinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Apomorphinei

St.

Read the full interaction
The complete list

Every Supplement Checked Against Apomorphine

All 1,452 ingredients in our database, ranked by severity — 67 with a Apomorphine interaction on file and 1,385 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Apomorphine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Activated Charcoal with Apomorphine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Apomorphine answer

Can you take St. John's Wort with Apomorphine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Apomorphine answer

Can you take Bitter Melon with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Apomorphine answer

Can you take Diosmin with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might increase levels of drugs that are substrates of P-glycoprotein (P-gp).

Full Diosmin + Apomorphine answer

Can you take Eleuthero with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of P-glycoprotein substrates.

Full Eleuthero + Apomorphine answer

Can you take Ginger with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.

Full Ginger + Apomorphine answer

Can you take Ginkgo with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with P-glycoprotein substrates might increase the levels and adverse effects of these substrates.

Full Ginkgo + Apomorphine answer

Can you take Green Tea with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea might increase the levels and adverse effects of P-glycoprotein (P-gp) substrates.

Full Green Tea + Apomorphine answer

Can you take Guar Gum with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Apomorphine answer

Can you take Gum Arabic with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Apomorphine answer

Can you take Hesperidin with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + Apomorphine answer

Can you take Indian Long Pepper with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase levels of P-glycoprotein substrates.

Full Indian Long Pepper + Apomorphine answer

Can you take Kava with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Apomorphine answer

Can you take Lemongrass with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.

Full Lemongrass + Apomorphine answer

Can you take Licorice with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.

Full Licorice + Apomorphine answer

Can you take Methoxylated Flavones with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that some methoxylated flavones including tangeretin, nobiletin, and heptamethoxyflavone, inhibit P-glycoprotein.

Full Methoxylated Flavones + Apomorphine answer

Can you take Milk Thistle with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Apomorphine answer

Can you take Moringa with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Moringa + Apomorphine answer

Can you take Neem with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Neem + Apomorphine answer

Can you take Oregon Grape with Apomorphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.

Full Oregon Grape + Apomorphine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Apomorphine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Apomorphine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Apomorphine sits in 4 interaction categories. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Apomorphine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Apomorphine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Apomorphine through this category.

Dopamine Agonists 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Apomorphine through this category.

About Apomorphine

Apomorphine injection is a dopamine agonist used to treat sudden 'off' episodes in people with advanced Parkinson's disease.

Generic name: Apomorphine  ·  Brand names: Uprima, Apokyn, APO-go, APO-go Pen, APO-go PFS, Kynmobi.

See the full Apomorphine Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Apomorphine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Apomorphine.

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Pharmacist Counseling Corner

Apomorphine & Supplements: Common Questions

What supplements interact with Apomorphine?
In our interaction database, 67 supplement and herbal ingredients have an interaction with Apomorphine on file — 2 rated major, 49 moderate, and 16 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, St. John's Wort, Brussels Sprout.
Which Apomorphine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Apomorphine?
That depends entirely on which supplement. The honest answer for Apomorphine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Uprima have the same supplement interactions as Apomorphine?
Yes — Uprima, Apokyn, APO-go, APO-go Pen, APO-go PFS and other brands all contain Apomorphine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Apomorphine and my other medications?
This page covers Apomorphine against supplements and herbal ingredients. Checking Apomorphine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Apomorphine Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.