Medication interaction hub

What Supplements Interact with Arbinoxamine, Pseudoephedrine?

Arbinoxamine, Pseudoephedrine brand name: Coldec TR. Every interaction below applies to the brands too.

63 Interactions 5 Major 45 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Arbinoxamine, Pseudoephedrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Arbinoxamine, Pseudoephedrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Coldec TR combines an antihistamine, arbinoxamine, with pseudoephedrine, a decongestant that acts as a stimulant, and that is exactly where most of its 63 supplement interactions come from. Treat this list with real care before adding a supplement. Forty-four of the ingredients pile more stimulation on top of the drug, raising the odds of a racing heart, jitteriness, and higher blood pressure. Ephedra is the most dangerous of these, one of five major-rated entries, but plain caffeine from coffee and tea does the same thing on a smaller scale and shows up all over the 45 moderate ratings.

The second pattern is absorption. Seventeen ingredients can change how much of an oral dose reaches your bloodstream, and activated charcoal, also rated major, can blunt the medication outright. Take supplements like that well apart from your dose, and read the five major entries first. The 13 minor ones can wait.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 45 Minor 13 No known interaction 1,389

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Arbinoxamine, Pseudoephedrine: Top Interactions at a Glance

The most significant Arbinoxamine, Pseudoephedrine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 63 interacting ingredients — plus 1,389 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Arbinoxamine, Pseudoephedrine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Arbinoxamine, Pseudoephedrinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Arbinoxamine, Pseudoephedrinei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Peyote + Arbinoxamine, Pseudoephedrinei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Arbinoxamine, Pseudoephedrinei

Theoretically, concomitant use might cause additive effects.

Read the full interaction Major Likelihood Probable Sida Cordifolia + Arbinoxamine, Pseudoephedrinei

Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Arbinoxamine, Pseudoephedrine

All 1,452 ingredients in our database, ranked by severity — 63 with a Arbinoxamine, Pseudoephedrine interaction on file and 1,389 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Arbinoxamine, Pseudoephedrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take European Mandrake with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Arbinoxamine, Pseudoephedrine answer

Can you take Fever Bark with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase or decrease the effects of stimulant drugs.

Full Fever Bark + Arbinoxamine, Pseudoephedrine answer

Can you take Glucomannan with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Arbinoxamine, Pseudoephedrine answer

Can you take Green Coffee with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Coffee + Arbinoxamine, Pseudoephedrine answer

Can you take Green Tea with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Tea + Arbinoxamine, Pseudoephedrine answer

Can you take Ilex Guayusa with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Ilex Guayusa + Arbinoxamine, Pseudoephedrine answer

Can you take Oolong Tea with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Oolong Tea + Arbinoxamine, Pseudoephedrine answer

Can you take Psilocybin with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.

Full Psilocybin + Arbinoxamine, Pseudoephedrine answer

Can you take Pu-erh Tea with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Pu-erh Tea + Arbinoxamine, Pseudoephedrine answer

Can you take Sodium Bicarbonate with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase levels and adverse effects of pseudoephedrine.

Full Sodium Bicarbonate + Arbinoxamine, Pseudoephedrine answer

Can you take Yerba Mate with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.

Full Yerba Mate + Arbinoxamine, Pseudoephedrine answer

Can you take 1,3-dmaa with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA is thought to have stimulant effects.

Full 1,3-dmaa + Arbinoxamine, Pseudoephedrine answer

Can you take 1,3-dmba with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.

Full 1,3-dmba + Arbinoxamine, Pseudoephedrine answer

Can you take 1,4-dmaa with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.

Full 1,4-dmaa + Arbinoxamine, Pseudoephedrine answer

Can you take Acacia Rigidula with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Acacia rigidula with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Acacia Rigidula + Arbinoxamine, Pseudoephedrine answer

Can you take Aconite with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining aconite with other stimulant drugs might alter the effects of the stimulant drug or increase the risk of cardiovasc...

Full Aconite + Arbinoxamine, Pseudoephedrine answer

Can you take Adrafinil with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking adrafinil with stimulant drugs might have additive stimulant effects.

Full Adrafinil + Arbinoxamine, Pseudoephedrine answer

Can you take Beta-methylphenethylamine (bmpea) with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking BMPEA with other stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Beta-methylphenethylamine (bmpea) + Arbinoxamine, Pseudoephedrine answer

Can you take Bitter Orange with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.

Full Bitter Orange + Arbinoxamine, Pseudoephedrine answer

Can you take Butcher's Broom with Arbinoxamine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Arbinoxamine, Pseudoephedrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Arbinoxamine, Pseudoephedrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Arbinoxamine, Pseudoephedrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Arbinoxamine, Pseudoephedrine sits in 4 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Arbinoxamine, Pseudoephedrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Arbinoxamine, Pseudoephedrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Arbinoxamine, Pseudoephedrine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Arbinoxamine, Pseudoephedrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Arbinoxamine, Pseudoephedrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Arbinoxamine, Pseudoephedrine.

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Pharmacist Counseling Corner

Arbinoxamine, Pseudoephedrine & Supplements: Common Questions

What supplements interact with Arbinoxamine, Pseudoephedrine?
More than you might expect — 63 in total, though they are far from equal: 5 are rated major, 45 moderate, and 13 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Ephedra, Peyote.
Which Arbinoxamine, Pseudoephedrine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Arbinoxamine, Pseudoephedrine?
Usually yes — most people on Arbinoxamine, Pseudoephedrine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Coldec TR have the same supplement interactions as Arbinoxamine, Pseudoephedrine?
Yes — Coldec TR all contain Arbinoxamine, Pseudoephedrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Arbinoxamine, Pseudoephedrine and my other medications?
This page covers Arbinoxamine, Pseudoephedrine against supplements and herbal ingredients. Checking Arbinoxamine, Pseudoephedrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.