Medication interaction hub

What Supplements Interact with Choline Magnesium Trisalicylate?

Choline Magnesium Trisalicylate brand names: Trilisate, Tricosal. Every interaction below applies to the brands too.

60 Interactions 4 Major 46 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Choline Magnesium Trisalicylate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Choline Magnesium Trisalicylate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Choline magnesium trisalicylate (Trilisate, Tricosal) is an aspirin-like salicylate taken for arthritis pain, and I would treat its supplement list with more care than most. Four of the 60 ingredients on file rate major, and the dominant theme is the liver: 38 of these ingredients can stress it, so combining them with this drug may raise the risk of liver damage. Ordinary alcohol sits in that major group, as does the herb Siberian cocklebur, which has been tied to cases of liver failure.

Another 17 can change how much of an oral dose actually gets absorbed; activated charcoal is the major entry there, and anything that absorbent needs spacing well apart from the medication. A smaller set adds to the drug's own effects; 46 entries rate moderate and 10 minor, but willow bark stands out because it is essentially plant aspirin, and stacking it on a salicylate doubles down on the same chemistry.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 46 Minor 10 No known interaction 1,392

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Choline Magnesium Trisalicylate: Top Interactions at a Glance

The most significant Choline Magnesium Trisalicylate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 60 interacting ingredients — plus 1,392 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Choline Magnesium Trisalicylate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Choline Magnesium Trisalicylatei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Choline Magnesium Trisalicylatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Choline Magnesium Trisalicylatei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Choline Magnesium Trisalicylatei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Choline Magnesium Trisalicylate

All 1,452 ingredients in our database, ranked by severity — 60 with a Choline Magnesium Trisalicylate interaction on file and 1,392 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Choline Magnesium Trisalicylate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Manchurian Thorn with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Choline Magnesium Trisalicylate answer

Can you take Activated Charcoal with Choline Magnesium Trisalicylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Choline Magnesium Trisalicylate answer

Can you take Beer with Choline Magnesium Trisalicylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Choline Magnesium Trisalicylate answer

Can you take Wine with Choline Magnesium Trisalicylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Choline Magnesium Trisalicylate answer

Can you take Coffee Charcoal with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Choline Magnesium Trisalicylate answer

Can you take European Mandrake with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Choline Magnesium Trisalicylate answer

Can you take Glucomannan with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Choline Magnesium Trisalicylate answer

Can you take Willow Bark with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, willow bark might increase the effects and adverse effects of choline magnesium trisalicylate.

Full Willow Bark + Choline Magnesium Trisalicylate answer

Can you take Ashwagandha with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Choline Magnesium Trisalicylate answer

Can you take Aspen with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aspen contains salicin, a plant salicylate.

Full Aspen + Choline Magnesium Trisalicylate answer

Can you take Black Cohosh with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Choline Magnesium Trisalicylate answer

Can you take Boldo with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Choline Magnesium Trisalicylate answer

Can you take Buchu with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Choline Magnesium Trisalicylate answer

Can you take Camphor with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Choline Magnesium Trisalicylate answer

Can you take Cassia Cinnamon with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Choline Magnesium Trisalicylate answer

Can you take Chaparral with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Choline Magnesium Trisalicylate answer

Can you take Comfrey with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Choline Magnesium Trisalicylate answer

Can you take Ephedra with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Choline Magnesium Trisalicylate answer

Can you take Epistane with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Choline Magnesium Trisalicylate answer

Can you take Fo-ti with Choline Magnesium Trisalicylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Choline Magnesium Trisalicylate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Choline Magnesium Trisalicylate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Choline Magnesium Trisalicylate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Choline Magnesium Trisalicylate sits in 3 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Choline Magnesium Trisalicylate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Choline Magnesium Trisalicylate through this category.

Choline Magnesium Trisalicylate (Trilisate) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Choline Magnesium Trisalicylate through this category.

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Take a Supplement Product? Check the Whole Bottle Against Choline Magnesium Trisalicylate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Choline Magnesium Trisalicylate.

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Products that contain Choline Magnesium Trisalicylate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Choline Magnesium Trisalicylate.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Choline Magnesium Trisalicylate & Supplements: Common Questions

What supplements interact with Choline Magnesium Trisalicylate?
More than you might expect — 60 in total, though they are far from equal: 4 are rated major, 46 moderate, and 10 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Choline Magnesium Trisalicylate supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Choline Magnesium Trisalicylate?
Usually yes — most people on Choline Magnesium Trisalicylate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Trilisate have the same supplement interactions as Choline Magnesium Trisalicylate?
Yes — Trilisate, Tricosal all contain Choline Magnesium Trisalicylate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Choline Magnesium Trisalicylate and my other medications?
This page covers Choline Magnesium Trisalicylate against supplements and herbal ingredients. Checking Choline Magnesium Trisalicylate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.