Medication interaction hub

What Supplements Interact with Nalbuphine?

Nalbuphine brand name: Nubain. Every interaction below applies to the brands too.

100 Interactions 7 Major 78 Moderate 15 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nalbuphine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nalbuphine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nalbuphine (Nubain) is an opioid pain reliever, which by itself raises the stakes of this page. Nearly four in five of the ingredients listed deepen sedation, layering their own drowsiness onto a medicine that already slows the brain and can slow breathing. Alcohol, whether beer or wine, is the best documented and most dangerous pairing, and kava earns the same top rating because stacked depressant effects can move past sleepiness into suppressed breathing.

The rest work differently. Activated charcoal and bulky fibers like glucomannan can blunt how much medicine the body absorbs, so keep them well apart from oral doses, while a few entries make a seizure slightly easier to trigger or add narcotic effects on top of an opioid. There are 100 ingredients here in total, and though 78 rate moderate and 15 minor, the seven majors are where I would spend my reading time first.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 78 Minor 15 No known interaction 1,352

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Nalbuphine: Top Interactions at a Glance

The most significant Nalbuphine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 100 interacting ingredients — plus 1,352 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Nalbuphine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Nalbuphinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Nalbuphinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Nalbuphinei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Nalbuphinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Nalbuphinei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Nalbuphinei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Nalbuphine

All 1,452 ingredients in our database, ranked by severity — 100 with a Nalbuphine interaction on file and 1,352 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nalbuphine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Psyllium with Nalbuphine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Nalbuphine answer

Can you take Poria Mushroom with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.

Full Poria Mushroom + Nalbuphine answer

Can you take Jackfruit with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.

Full Jackfruit + Nalbuphine answer

Can you take Jamaican Dogwood with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Jamaican dogwood may potentiate sedative effects.

Full Jamaican Dogwood + Nalbuphine answer

Can you take Kratom with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.

Full Kratom + Nalbuphine answer

Can you take Lemon Balm with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Full Lemon Balm + Nalbuphine answer

Can you take Mace with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several volatile oils in mace, such as methyleugenol, isoeugenol, safrole, myristicin, 1,8-cineole, and geranyl acetate, seem to have sedati...

Full Mace + Nalbuphine answer

Can you take Magnolia with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.

Full Magnolia + Nalbuphine answer

Can you take Marsh Labrador Tea with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Marsh Labrador tea can potentiate effects of barbiturates and alcohol.

Full Marsh Labrador Tea + Nalbuphine answer

Can you take Melatonin with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Nalbuphine answer

Can you take Motherwort with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.

Full Motherwort + Nalbuphine answer

Can you take Nutmeg with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.

Full Nutmeg + Nalbuphine answer

Can you take Oregon Grape with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Nalbuphine answer

Can you take Passion Flower with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Nalbuphine answer

Can you take Phellodendron with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the sedative effects of CNS depressants.

Full Phellodendron + Nalbuphine answer

Can you take Phenibut with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.

Full Phenibut + Nalbuphine answer

Can you take Pinellia Ternata with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Nalbuphine answer

Can you take Rauvolfia Vomitoria with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Full Rauvolfia Vomitoria + Nalbuphine answer

Can you take Rauwolscine with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Nalbuphine answer

Can you take Saffron with Nalbuphine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Nalbuphine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nalbuphine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nalbuphine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nalbuphine sits in 4 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Nalbuphine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nalbuphine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Nalbuphine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Nalbuphine through this category.

About Nalbuphine

Nalbuphine Injection is an opioid pain reliever used to manage severe pain, as a supplement to anesthesia, and for pain relief during labor and delivery.

Generic name: Nalbuphine  ·  Brand name: Nubain.

See the full Nalbuphine Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nalbuphine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nalbuphine.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Nalbuphine & Supplements: Common Questions

What supplements interact with Nalbuphine?
Our database currently documents 100 ingredients with a known Nalbuphine interaction (7 major, 78 moderate, 15 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 100. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Nalbuphine supplement interactions are the most serious?
The 7 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb) — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Nalbuphine?
Plenty of supplements coexist fine with Nalbuphine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Nubain have the same supplement interactions as Nalbuphine?
Yes — Nubain all contain Nalbuphine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Nalbuphine and my other medications?
This page covers Nalbuphine against supplements and herbal ingredients. Checking Nalbuphine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nalbuphine Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.