Medication interaction hub

What Supplements Interact with Sulfasalazine?

Sulfasalazine brand names: SAS, Azulfidine EN-Tabs, Azulfidine. Every interaction below applies to the brands too.

39 Interactions 1 Major 28 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 28, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Sulfasalazine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Sulfasalazine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Activated charcoal is the single major-rated risk for sulfasalazine (Azulfidine), because charcoal can bind the drug in the gut and cut how much your body absorbs, weakening a medicine people rely on for rheumatoid arthritis or ulcerative colitis. That entry alone earns this list of 39 supplements and herbs a careful read. Twenty of the entries share one theme, added sun sensitivity, since sulfasalazine itself can make skin react to sunlight and these herbs and oils pile onto that.

Seventeen more change how oral drugs are absorbed, mostly fibers and gums such as glucomannan; take those well apart from your dose. Turmeric pushes the other way, with curcumin shown to raise sulfasalazine blood levels 3.2-fold, enough to amplify side effects. Only one of the 39 is rated major, with 28 moderate and 10 minor, but between sun reactions and shifted drug levels, this list deserves real respect.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 28 Minor 10 No known interaction 1,413

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Sulfasalazine: Top Interactions at a Glance

The most significant Sulfasalazine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 39 interacting ingredients — plus 1,413 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Sulfasalazine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Sulfasalazinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Sulfasalazine

All 1,452 ingredients in our database, ranked by severity — 39 with a Sulfasalazine interaction on file and 1,413 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Sulfasalazine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take St. John's Wort with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Sulfasalazine answer

Can you take Alfalfa with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Sulfasalazine answer

Can you take Bishop's Weed with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Sulfasalazine answer

Can you take Chlorella with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chlorella might have additive effects with photosensitizing drugs.

Full Chlorella + Sulfasalazine answer

Can you take Cilantro with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.

Full Cilantro + Sulfasalazine answer

Can you take Coriander with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.

Full Coriander + Sulfasalazine answer

Can you take Fig with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.

Full Fig + Sulfasalazine answer

Can you take Guar Gum with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Sulfasalazine answer

Can you take Gum Arabic with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Sulfasalazine answer

Can you take Khella with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Sulfasalazine answer

Can you take Light Therapy with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Sulfasalazine answer

Can you take Lime with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Sulfasalazine answer

Can you take Quercetin with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, quercetin might increase the effects and adverse effects of sulfasalazine.

Full Quercetin + Sulfasalazine answer

Can you take Rue with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Sulfasalazine answer

Can you take Slippery Elm with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Sulfasalazine answer

Can you take Tragacanth with Sulfasalazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Sulfasalazine answer

Can you take Thyroid Extract with Sulfasalazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Sulfasalazine answer

Can you take Agar with Sulfasalazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Sulfasalazine answer

Can you take Algin with Sulfasalazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Sulfasalazine answer

Can you take Black Psyllium with Sulfasalazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Sulfasalazine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Sulfasalazine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Sulfasalazine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Sulfasalazine sits in 3 interaction categories. Open any one to see what the group means:

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Sulfasalazine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Sulfasalazine through this category.

Sulfasalazine (Azulfidine) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Sulfasalazine through this category.

About Sulfasalazine

Sulfasalazine is an anti-inflammatory medicine used to treat ulcerative colitis and, in its delayed-release form, rheumatoid arthritis and juvenile rheumatoid arthritis.

Generic name: Sulfasalazine  ·  Brand names: SAS, Azulfidine EN-Tabs, Azulfidine.

See the full Sulfasalazine drug information

Related: does Sulfasalazine deplete any nutrients?

Sulfasalazine has 3 reported nutrient associations in the research literature — see the Sulfasalazine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Sulfasalazine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Sulfasalazine.

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Products that contain Sulfasalazine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Sulfasalazine.

Citrus Bergamot Extract 2000 mg by tnvitamins contains Bergamot Bergamot 500 mg by Solaray contains Bergamot Bergamot 375 by ProCaps contains Bergamot Resveratrol Berberine Quercetin Apple Cider Vinegar Acai & Noni by Nutra Harmony contains Bergamot BCT Herbal Oil by Professional Botanicals contains Chenopodium Oil
Pharmacist Counseling Corner

Sulfasalazine & Supplements: Common Questions

What supplements interact with Sulfasalazine?
In our interaction database, 39 supplement and herbal ingredients have an interaction with Sulfasalazine on file — 1 rated major, 28 moderate, and 10 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Bergamot, Chenopodium Oil.
Which Sulfasalazine supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Sulfasalazine?
That depends entirely on which supplement. The honest answer for Sulfasalazine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like SAS have the same supplement interactions as Sulfasalazine?
Yes — SAS, Azulfidine EN-Tabs, Azulfidine all contain Sulfasalazine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Sulfasalazine deplete any vitamins or nutrients?
It might — Sulfasalazine has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Sulfasalazine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Sulfasalazine and my other medications?
This page covers Sulfasalazine against supplements and herbal ingredients. Checking Sulfasalazine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Sulfasalazine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 28, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.