Panax Notoginseng + Sulfasalazine
Sulfasalazine brand names: SAS, Azulfidine EN-Tabs, Azulfidine.
We found no known interaction between Panax Notoginseng and Sulfasalazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Panax Notoginseng and Sulfasalazine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sulfasalazine and Panax Notoginseng in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Panax Notoginseng safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Sulfasalazine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Sulfasalazine is filed under 3 classifications — including photosensitizing drugs, oral drugs. Panax Notoginseng has documented interactions with 4 drug classes — the most serious being aspirin (moderate), caffeine (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Sulfasalazine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Panax Notoginseng Does Interact With Other Medications
Panax Notoginseng has 207 moderate known drug interactions in our database — Sulfasalazine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Panax Notoginseng
We haven’t checked that one against Panax Notoginseng yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Panax Notoginseng. Pick one to open its full report.
Panax Notoginseng in Pregnancy & Breastfeeding
When used orally. Ginsenoside Rb1, an active constituent of Panax notoginseng, has teratogenic effects in animal models.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Sulfasalazine Is Prescribed For, and What Panax Notoginseng Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Sulfasalazine is a prescription medicine with approved uses on its FDA label. Panax Notoginseng is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Sulfasalazine is prescribed for: Sulfasalazine tablets (Azulfidine and generic) treat mild to moderate ulcerative colitis and are used as an add-on therapy in severe ulcerative colitis. They also help keep ulcerative colitis in remission — reducing the frequency of flare-ups. The delayed-release tablets (Azulfidine EN-tabs and generic delayed-release) have the additional approvals of treating rheumatoid arthritis in adults who haven't responded well enough to NSAIDs or salicylates, and polyarticular-course juvenile rheumatoid arthritis in children who also haven't responded adequately to those drugs.
Panax Notoginseng has been studied for:
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Ulcerative colitis studied, not established Panax Notoginseng has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Panax Notoginseng for ulcerative colitis
Rectal Panax notoginseng has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sulfasalazine on your own; if you are taking Panax Notoginseng for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Sulfasalazine
This page covers Panax Notoginseng only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sulfasalazine page lists 39 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Alfalfa (moderate), Angelica Archangelica (moderate), Arrach (moderate) and Bergamot (moderate).
By severity: 1 major · 28 moderate · 10 minor.
From our pharmacist’s overview on the Sulfasalazine page
“Activated charcoal is the single major-rated risk for sulfasalazine (Azulfidine), because charcoal can bind the drug in the gut and cut how much your body absorbs, weakening a medicine people rely on for rheumatoid arthritis or ulcerative colitis. That entry alone earns this list of 39 supplements and herbs a careful read.”
Reviewed by 2 · Jul 18, 2026
Taking Panax Notoginseng as Part of a Dietary Supplement Product? Check It for Interactions
We hold 55 real supplement products containing Panax Notoginseng, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Panax Notoginseng. Even though Panax Notoginseng itself has no known interaction with Sulfasalazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Panax Notoginseng and Sulfasalazine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#463 of 1,452 supplements looked up here in the last 7 days
#911 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Panax Notoginseng reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Panax Notoginseng and Sulfasalazine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Panax Notoginseng
What is Panax Notoginseng?
- Bleeding and bruising
- Heart and circulation health
- High blood pressure
- Chest pain (angina)
- Inflammation and swelling
Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation. Human evidence for these uses is limited and mostly early, so it should not replace proven treatments. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Panax notoginseng · Araliaceae · Root (and sometimes flowers and leaves) · Capsules, tablets, powders, topical preparations, and dried root used in traditional formulas
An interaction check asks whether these two react with each other — it does not ask whether Panax Notoginseng is a good idea for someone in your situation. Here is what our Panax Notoginseng record says about it on its own.
Panax Notoginseng: dosing
There is no well-established standard dose of Panax notoginseng for supplement use. Doses used in traditional practice and in studies have varied widely depending on the form and product.If you choose to use it, follow the directions on the product label and do not exceed them.
From our Panax Notoginseng monograph — the full record covers uses, side effects and every documented interaction.
About Sulfasalazine
What Is Sulfasalazine Used For?
Brand names: SAS, Azulfidine EN-Tabs, Azulfidine
Sulfasalazine tablets (Azulfidine and generic) treat mild to moderate ulcerative colitis and are used as an add-on therapy in severe ulcerative colitis. They also help keep ulcerative colitis in remission — reducing the frequency of flare-ups.
The delayed-release tablets (Azulfidine EN-tabs and generic delayed-release) have the additional approvals of treating rheumatoid arthritis in adults who haven't responded well enough to NSAIDs or salicylates, and polyarticular-course juvenile rheumatoid arthritis in children who also haven't responded adequately to those drugs.
Other Drugs & Panax Notoginseng
Browse every other medication we’ve checked against Panax Notoginseng — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
207 interactions
- Theophylline ›
- Aspirin ›
- Naproxen ›
- Estradiol ›
- Propranolol ›
- Verapamil ›
- Acetaminophen ›
- Diazepam ›
- Lofepramine ›
- Nortriptyline ›
- Bendamustine ›
- Caffeine (otc Drug) ›
- Cyclobenzaprine ›
- Desipramine ›
- Riluzole ›
- Warfarin Sodium ›
- Asenapine ›
- Caffeine (prescription Drug) ›
- Clomipramine ›
- Clozapine ›
- Flutamide ›
- Imipramine ›
- Propafenone ›
- Ropinirole ›
- Tasimelteon ›
- Tizanidine ›
- Zileuton ›
- Acetylsalicylic Acid ›
- Agomelatine ›
- Amitriptyline ›
- Anagrelide ›
- Bendamustine Hydrochloride ›
- Chlordiazepoxide ›
- Clopidogrel ›
- Enasidenib ›
- Estrogen ›
- Ethinyl Estradiol ›
- Etonogestrel ›
- Fenfluamine ›
- Fezolinetant ›
- Fluvoxamine ›
- Grepafloxacin ›
- Haloperidol ›
- Levobupivacaine ›
- Mexiletine ›
- Mirtazapine ›
- Naproxen Sodium ›
- Oestrogen ›
- Olanzapine ›
- Ondansetron ›
- Paracetamol ›
- Pentazocine ›
- Perampanel ›
- Pirfenidone ›
- Pomalidomide ›
- Propranolol Hydrochloride ›
- Ramelteon ›
- Rasagiline ›
- Ropivacaine ›
- Tacrine ›
Showing 60 of 207 moderate interactions — see all 207 on the Panax Notoginseng page.
No interaction 2,622 drugs checked — show the list
We also checked Panax Notoginseng against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Prednisone ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Atorvastatin Calcium ›
Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Panax Notoginseng list.
Panax Notoginseng References
The 15 references that drive our Panax Notoginseng monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. New York, NY: CRC Press, LLC 1999:101-102.
- Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Seattle, WA: Eastland Press, 1996:359-60.
- Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
- Du XF, Yin XP, Zhang GL, Shi HJ, Shao MH. Interstitial granulomatous drug reaction to a Chinese herb extract. Eur J Dermatol. 2012 May-Jun;22(3):419-20. PubMed
- Liu R, Qin M, Hang P, Liu Y, Zhang Z, Liu G. Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Phytother Res. 2012 Aug;26(8):1113-8.
- Shang Q, Xu H, Liu Z, Chen K, Liu J. Oral Panax notoginseng Preparation for Coronary Heart Disease: A Systematic Review of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2013;2013:940125.
- Tian Z, Pang H, Du S, Lu Y, Zhang L, Wu H, Guo S, Wang M, Zhang Q. Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:136-143. PubMed
- Xu D, Huang P, Yu Z, Xing DH, Ouyang S, Xing G. Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action. Front Neurol. 2015 Jan 7;5:274. PubMed
- Yang X, Xiong X, Wang J. Sanqi panax notoginseng injection for angina pectoris. Evid Based Complement Alternat Med. 2014;2014:963208. PubMed
- Yin Z, Ma L, Xu J, Xia J, Luo D. Pustular drug eruption due to Panax notoginseng saponins. Drug Des Devel Ther. 2014 Jul 16;8:957-61. PubMed
- Song H, Wang P, Liu J, Wang C. Panax notoginseng Preparations for Unstable Angina Pectoris: A Systematic Review and Meta-Analysis. Phytother Res. 2017 Jun 20.
- Tian Z, Pang H, Zhang Q, et al. Effect of aspirin on the pharmacokinetics and absorption of panax notoginsengsaponins. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 2;1074-75.
- Li C, Xu T, Zhou P, et al. Post-marketing safety surveillance and re-evaluation of Xueshuantong injection. BMC Complement Altern Med. 2018;18(1):277. PubMed
- Liu L, Shen XJ, Xue LJ, Yao SK, Zhu JY. Submucosal hematoma with a wide range of lesions, severe condition and atypical clinical symptoms: A case report. World J Clin Cases 2021;9(20):5683-5688. PubMed
- Qian J, Chen W, Wu J, et al. Effects and Mechanism of Action of Panax notoginseng Saponins on the Pharmacokinetics of Warfarin. Eur J Drug Metab Pharmacokinet 2022;47(3):331-342. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Sulfasalazine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Sulfasalazine as a medicine that can lower these. This is not an interaction with Panax Notoginseng — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Sulfasalazine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Panax Notoginseng and Sulfasalazine Together: Common Questions
Is it safe to take Panax Notoginseng with Sulfasalazine?
Do Panax Notoginseng and Sulfasalazine have any of the same side effects?
Are Panax Notoginseng and Sulfasalazine used for the same thing?
How was the Panax Notoginseng and Sulfasalazine combination checked?
Does Panax Notoginseng interact with any other medications?
Does Sulfasalazine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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