Medication interaction hub

What Supplements Interact with Trandolapril?

Trandolapril brand name: Mavik. Every interaction below applies to the brands too.

149 Interactions 6 Major 119 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Trandolapril? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Trandolapril against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Trandolapril (Mavik) treats high blood pressure, and I'd want anyone taking it to read this list of 149 supplements and herbs carefully, with the six major entries first (another 119 are rated moderate and 24 minor). Most of what's here either adds to trandolapril's pressure-lowering effect and can drop you too far, or pushes back against it so your pressure creeps up. Activated charcoal stands apart among the majors because it soaks up the pill before your body absorbs it.

Trandolapril is also an ACE inhibitor, meaning it keeps potassium in your body, so potassium supplements raise the risk of blood potassium climbing too high. A smaller group, six ingredients including Siberian cocklebur, can strain the kidneys, which matters because this drug already affects kidney function. Space charcoal-type products well apart from your dose, and treat every major entry as something to clear with your pharmacist first.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 119 Minor 24 No known interaction 1,303

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Trandolapril: Top Interactions at a Glance

The Trandolapril supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 149 interacting ingredients — plus 1,303 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Trandolapril Combinations Today

The Trandolapril + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Capsicum + Trandolaprili

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Read the full interaction Moderate Likelihood Possible Rice Protein + Trandolaprili

In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE).

Read the full interaction Moderate Likelihood Possible Horny Goat Weed + Trandolaprili

Theoretically, horny goat weed might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Pomegranate + Trandolaprili

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Major Likelihood Likely American Hellebore + Trandolaprili

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Trandolaprili

Siberian cocklebur can adversely affect the kidney.

Read the full interaction
The complete list

Every Supplement Checked Against Trandolapril

All 1,452 ingredients in our database, ranked by severity — 149 with a Trandolapril interaction on file and 1,303 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Trandolapril?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Capsicum with Trandolapril?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Full Capsicum + Trandolapril answer

Can you take Rice Protein with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE).

Full Rice Protein + Trandolapril answer

Can you take Horny Goat Weed with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the risk of hypotension.

Full Horny Goat Weed + Trandolapril answer

Can you take Pomegranate with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Full Pomegranate + Trandolapril answer

Can you take Fever Bark with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might alter the effects of antihypertensive drugs.

Full Fever Bark + Trandolapril answer

Can you take Fish Oil with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Trandolapril answer

Can you take Glucomannan with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Trandolapril answer

Can you take Japanese Persimmon with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Japanese persimmon is thought to have hypotensive effects.

Full Japanese Persimmon + Trandolapril answer

Can you take Java Tea with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some preliminary clinical evidence suggests that Java tea has antihypertensive effects.

Full Java Tea + Trandolapril answer

Can you take L-arginine with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.

Full L-arginine + Trandolapril answer

Can you take Olive Oil with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking olive oil with antihypertensive drugs might have additive effects on blood pressure.

Full Olive Oil + Trandolapril answer

Can you take Periwinkle with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constitu...

Full Periwinkle + Trandolapril answer

Can you take Sesame with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.

Full Sesame + Trandolapril answer

Can you take Sodium with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Trandolapril answer

Can you take Taurine with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Taurine + Trandolapril answer

Can you take Wild Carrot with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive doses of wild carrot seed oil might interfere with antihypertensive therapy due to cardiotonic effects.

Full Wild Carrot + Trandolapril answer

Can you take Wine with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Wine + Trandolapril answer

Can you take Yohimbe with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yohimbe might reduce the effects of antihypertensive drugs.

Full Yohimbe + Trandolapril answer

Can you take Adrafinil with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the effects of antihypertensive drugs.

Full Adrafinil + Trandolapril answer

Can you take Agmatine with Trandolapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Trandolapril answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Trandolapril is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Trandolapril, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Trandolapril sits in 4 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Trandolapril through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Trandolapril through this category.

Ace Inhibitors (Aceis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Trandolapril through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Trandolapril through this category.

About Trandolapril

Trandolapril is an ACE inhibitor (a blood pressure-lowering medicine) used to treat high blood pressure and to reduce the risk of death and hospitalization in patients with heart failure or reduced heart function after a heart attack.

Generic name: Trandolapril  ·  Brand name: Mavik.

See the full Trandolapril drug information

Related: does Trandolapril deplete any nutrients?

Trandolapril has 1 reported nutrient association in the research literature — see the Trandolapril nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Trandolapril

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Trandolapril.

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Pharmacist Counseling Corner

Trandolapril & Supplements: Common Questions

What supplements interact with Trandolapril?
Our database currently documents 149 ingredients with a known Trandolapril interaction (6 major, 119 moderate, 24 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 149. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Trandolapril supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Trandolapril?
Plenty of supplements coexist fine with Trandolapril; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Mavik have the same supplement interactions as Trandolapril?
Yes — Mavik all contain Trandolapril, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Trandolapril deplete any vitamins or nutrients?
It might — Trandolapril has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Trandolapril nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Trandolapril and my other medications?
This page covers Trandolapril against supplements and herbal ingredients. Checking Trandolapril against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Trandolapril drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.