Major interaction on record — check this product against your medications before combining. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Adaptiv Ingredients & Drug Interactions

by doTERRA

Adaptiv label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Adaptiv against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Adaptiv is a dietary supplement by doTERRA with 7 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation and calming.Based on those ingredients, 1,300 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Fennel seed Oil, Coriander seed Oil, Gamma Aminobutryic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Adaptiv by doTERRA

Ask about any prescription or over-the-counter medication and we check it for interactions with Adaptiv by doTERRA — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Adaptiv by doTERRA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 7 active ingredients.
  • “Adaptive Blend” is a proprietary blend — the label gives one combined amount (80 mg) without saying how much of each component you get.

Adaptiv contains 7 ingredients total. The main active components are an Adaptive Blend that includes Lavender, Coriander seed Oil, wild Orange peel Oil, Fennel seed Oil, Ahiflower seed oil, and Gamma Aminobutyric Acid (GABA).

These are complemented by several inactive ingredients—Sunflower Oil, Hypromellose, Candelilla Wax, Maltodextrin, and mixed Tocopherols—that serve as fillers and capsule material. Each active ingredient in the blend brings its own profile: Lavender and Fennel are traditional calming herbs, Coriander seed and wild Orange are aromatic seed and peel oils, Ahiflower provides omega fatty acids, and GABA is an amino acid known for its relaxing effects in the nervous system.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Calming and stress adaptation support.
  • We looked for evidence on: Anxiety, Insomnia, Perioperative anxiety, Pre-procedural anxiety, Post-traumatic stress disorder (PTSD), Depression — and 4 related terms.
  • The closest evidence on file: Coriander is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Coriander is rated "Insufficient Reliable Evidence To Rate" for Insomnia.
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.

The evidence for most ingredients in Adaptiv is limited. Lavender is rated possibly effective for dysmenorrhea (menstrual cramps) but lacks reliable evidence for pre-procedural anxiety and several other uses.

Fennel is also rated possibly effective for dysmenorrhea. For Coriander seed Oil, wild Orange peel Oil, GABA, and Ahiflower seed oil, the data we hold shows insufficient reliable evidence to rate their effectiveness for the conditions they're traditionally used for—including anxiety, stress relief, and sleep support.

If you're considering this product for a specific purpose, it's worth discussing what the evidence actually shows with your pharmacist or doctor.

The evidence, ingredient by ingredient Lavender Coriander Sweet Orange Fennel Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lavender is generally well tolerated in approved forms when taken orally; the most common side effects are breath odor, constipation, diarrhea, nausea, and headache. Topically, it may cause allergic skin reactions.

Coriander is generally safe in normal food amounts; concentrated doses lack safety data. Wild Orange fruit and juice are safe as food, but concentrated oils and extracts have not been well studied.

Fennel is generally safe as a food but should be avoided in medicinal amounts during pregnancy and lactation because constituents have hormone-like activity and safety is not well established. GABA is often well tolerated short-term orally, with drowsiness, nausea, and muscle weakness reported in some cases, but long-term safety is not well studied.

Pregnancy and lactation data are incomplete for most ingredients. Fennel is rated possibly unsafe during pregnancy and lactation.

For Lavender, Coriander, GABA, and wild Orange, we either hold no specific pregnancy or lactation safety data on file, or the data is insufficient—talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Lavender Coriander Sweet Orange Fennel Gamma-aminobutyric Acid (gaba)

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Coriander, Fennel, Gamma-aminobutyric Acid (gaba), Lavender, Sweet Orange.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,301 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Adaptiv, double-check your medications against these drug types—worst severity first. If you take organic anion-transporting polypeptide substrates, pravastatin, ivermectin, celiprolol, or calcium-fortified supplements alongside medication, wild Orange can significantly change how your body absorbs them (Major severity).

Antihypertensive drugs (blood pressure medications), antidiabetes drugs, CNS depressants (sedatives, sleep aids, pain relievers), anticoagulants or antiplatelets (blood thinners), contraceptives (birth control), estrogen therapy, photosensitizing drugs, and ciprofloxacin can all have moderate-severity interactions with one or more ingredients. No interactions are documented in our data for Ahiflower seed oil or Alkaloids.

Use the medication checker on this page to confirm your drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Adaptiv may appeal to you if you're looking for a blend of calming botanicals and GABA, but the evidence that it works for stress or sleep is not well established in the data we hold. The main caution is interactions: if you take blood thinners, birth control, heart or diabetes medications, or any CNS depressants, you need to check your specific drugs before starting this product.

Talk to your pharmacist or doctor first, especially if you're pregnant, breastfeeding, or taking any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adaptiv, straight from the product label.

Brand doTERRA
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 274002
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adaptiv by doTERRA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Adaptive Blend80 mg--
Lavender0 NP--
Coriander seed Oil0 NP--
wild Orange peel Oil0 NP--
Fennel seed Oil0 NP--
Ahiflower seed oil170 mg--
Gamma Aminobutryic Acid100 mg--
Alkaloids87.5 mcg--

Other ingredients: Sunflower Oil, Hypromellose, Candelilla Wax, Maltodextrin, mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Calming blend capsules

A mood enhancing and relaxing formula, this proprietary blend of ingredients helps when adapting to stressful situations and new surroundings.

FDA Statement of Identity

Dietary Supplement

Formula

doTERRA Adaptiv Calming Blend Capsules combine clinically studied botanicals with the calming benefits of specifically selected CPTG essential oils.

Suggested/Recommended/Usage/Directions

Directions for use: Take 1 capsule as needed.

Precautions

Caution: Keep out of reach of children.

If pregnant, nursing, or under a doctor's care, consult your physician.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Ahiflower is a registered trademark of Natures Crops International

General Statements

FPO

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Adaptiv by doTERRA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Adaptiv label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Adaptiv by doTERRA

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Adaptive Blend

80 mg per serving

Ahiflower seed oil

170 mg per serving

Gamma Aminobutryic Acid

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma Aminobutryic Acid monograph & interactions

Alkaloids

87.5 mcg per serving Form: Sceletium tortuosum

Other (inactive) ingredients: Sunflower Oil, Hypromellose, Candelilla Wax, Maltodextrin, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Adaptiv by doTERRA Drug Interactions

Want to check YOUR meds against Adaptiv?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,300Drugs
48 Major 1,252 Moderate

Ingredients driving the most interactions

Fennel seed Oil 740
Coriander seed Oil 717
Gamma Aminobutryic Acid 419
Lavender 248
wild Orange peel Oil 246

Individual Drug Interactions

The ingredients in Adaptiv interact with 1,300 drugs. Click any drug to see the details.

5 of the 7 ingredients in Adaptiv interact with drugs. Each result below shows which ingredient is responsible. Fennel seed Oil Coriander seed Oil Gamma Aminobutryic Acid Lavender wild Orange peel Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Adaptiv with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel seed Oil6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel seed Oil full monograph & interactions

Coriander seed Oil4 drug types · 717 drugs

Antidiabetes Drugs

Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Evidence from animal research suggests that coriander fruit and coriander extract can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Evidence from animal research suggests that coriander fruit can lower blood pressure.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Evidence from animal research suggests that coriander fruit extract has sedative effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects.

Likelihood Possible Evidence D
Coriander seed Oil full monograph & interactions

Gamma Aminobutryic Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma Aminobutryic Acid full monograph & interactions

Lavender1 drug type · 248 drugs

Cns Depressants

Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.

Likelihood Unlikely Evidence D
Lavender full monograph & interactions

wild Orange peel Oil7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
wild Orange peel Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Adaptiv, from the product label.

doTERRA

See all doTERRA products
Name
doTERRA Intl, LLC
Street Address
389 S 1300 W
City
Pleasant Grove
State
UT
ZipCode
84062
Phone Number
1-800-411-8151
Pharmacist Counseling Corner

Adaptiv by doTERRA: Common Questions

Does Adaptiv by doTERRA interact with any medications?
Yes. Based on its ingredients, Adaptiv has a known interaction with 1,300 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adaptiv contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Adaptiv safe during pregnancy?
Fennel, one of the ingredients, is rated possibly unsafe in pregnancy due to hormone-like effects and limited safety data. For the other ingredients, we don't hold enough pregnancy safety data to know either way. Talk with your doctor or pharmacist before taking Adaptiv if you're pregnant or planning to be.
Can I take Adaptiv while breastfeeding?
Fennel is rated possibly unsafe while breastfeeding, and GABA safety is not well established during lactation. For the remaining ingredients, safety data while breastfeeding is not on file. Check with your doctor or pharmacist for personalized advice.
What side effects might I experience from Adaptiv?
The most commonly reported side effects are from Lavender—breath odor, constipation, diarrhea, nausea, and headache when taken orally. GABA may cause drowsiness, nausea, or muscle weakness. Allergic reactions are rare but possible, especially to Coriander or Fennel in sensitive individuals. If you experience unusual symptoms, stop and talk to your pharmacist.
Does Adaptiv actually work for anxiety or stress?
The evidence for most ingredients—Coriander, wild Orange, Ahiflower, and GABA—is insufficient to say whether they help anxiety. Lavender and Fennel lack reliable evidence for pre-procedural anxiety as well. If you're considering Adaptiv for a specific condition, your pharmacist or doctor can help you weigh what evidence exists and whether it's right for you.
What is GABA in Adaptiv, and does it actually get absorbed?
GABA is an amino acid that your nervous system uses to promote relaxation. The problem is that oral GABA supplements have unclear effects in humans—we don't have strong evidence they raise brain GABA or produce the effects you'd expect. Short-term use is generally well tolerated, but long-term safety is not well studied.
Why do I need to separate Adaptiv from some medications by 4 hours?
Wild Orange peel Oil in Adaptiv can block how your gut absorbs certain drugs, reducing how well they work. Taking them at least 4 hours apart gives each time to be absorbed without interference. Your pharmacist can help you space them correctly based on your specific medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adaptiv label
Go deeper

The Full Monographs Behind Adaptiv’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lavender

Interacts with 248 drugs

Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...

Read the full Lavender monograph → Herb & supplement monograph

Coriander

Interacts with 717 drugs

Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people,...

Read the full Coriander monograph → Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

Adaptiv's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 78 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lavender 20 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Akhondzadeh S, Kashani L, Fotouhi A, et al. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:123-7. PubMed
  4. Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
  5. Coulson IH and Khan AS. Facial 'pillow' dermatitis due to lavender oil allergy. Contact Dermatitis 1999;41(2):111. PubMed
  6. Woelk, H. and Schlafke, S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17(2):94-99. PubMed
  7. Kasper, S., Gastpar, M., Muller, W. E., Volz, H. P., Moller, H. J., Dienel, A., and Schlafke, S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, plac
  8. Uehleke, B., Schaper, S., Dienel, A., Schlaefke, S., and Stange, R. Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. Phytomedicine. 6-15-2012;19(8-9):665-671. PubMed
  9. Brandao FM. Occupational allergy to lavender oil. Contact Dermatitis 1986;15(4):249-250. PubMed
  10. Rademaker M. Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 1994;31(1):58-59. PubMed
  11. Kasper S, Gastpar M, Müller WE, et al. Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69. PubMed
  12. Farshbaf-Khalili A, Kamalifard M, Namadian M. Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Complement Ther Clin Pract 2018;31:132-8. PubMed
  13. Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL. Contact allergy and allergic contact dermatitis caused by lavender: A retrospective study from an Australian clinic. Contact Dermatitis. 2019;81(1):37-42. PubMed
  14. Donelli D, Antonelli M, Bellinazzi C, Gensini GF, Firenzuoli F. Effects of lavender on anxiety: A systematic review and meta-analysis. Phytomedicine. 2019;65:153099. PubMed
  15. Firoozeei TS, Feizi A, Rezaeizadeh H, Zargaran A, Roohafza HR, Karimi M. The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Med 2021;59:102 PubMed
  16. Kodama T, Watanabe T, Mataki N, Kanoh S, Kichikawa Y. Acute eosinophilic pneumonia following aromatherapy with essential oil. Respir Med Case Rep 2022;37:101657. PubMed
  17. Barbaud A, Kurihara F, Raison-Peyron N, et al. Allergic contact dermatitis from essential oil in consumer products: Mode of uses and value of patch-tests with an essential oil series. Results of a French study of the DAG (dermato-allergy group of the Fren
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Coriander 12 references
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Sweet Orange 17 references
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Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
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See these in context on the Fennel monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
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  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
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See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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