Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Advanced Probiotic 40 Billion CFU Ingredients & Drug Interactions

by eXplicit Supplements

Advanced Probiotic 40 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Probiotic 40 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Advanced Probiotic 40 Billion CFU is a dietary supplement by eXplicit Supplements with 6 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus LA-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Probiotic 40 Billion CFU by eXplicit Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Probiotic 40 Billion CFU by eXplicit Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Probiotic 40 Billion CFU by eXplicit Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “MAKTREK Proprietary Blend of Probiotic Bacteria” is a proprietary blend — the label doesn't break down how much of each component you get.

This product has 6 active ingredients: several Lactobacillus strains (plantarum, acidophilus, and paracasei), Bifidobacterium animalis lactis, Fructooligosaccharide (a type of dietary fiber that feeds beneficial bacteria), and a Marine Polysaccharide Complex. These are live probiotic bacteria — beneficial microorganisms meant to support your gut — plus a prebiotic fiber to help them thrive.

The capsule also contains inactive ingredients: cellulose, rice maltodextrin, and L-leucine, which are fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and gut balance support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation.

L. acidophilus is possibly effective for irritable bowel syndrome (IBS), helping with Helicobacter pylori (a stomach bacterium), preventing antibiotic-associated diarrhea, and treating bacterial vaginosis. However, the evidence isn't established in our data for acute respiratory distress syndrome, and it appears possibly ineffective for atopic disease (allergic conditions).

For the other ingredients — Lactobacillus paracasei, Bifidobacterium animalis, and Fructooligosaccharide — the evidence on file is too limited to rate whether they work for osteoporosis, constipation, diabetes, travelers' diarrhea, or high cholesterol.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus is generally well tolerated in healthy adults and children, though the data are limited. The main concern: because it's a live organism, it theoretically could cause infection in some people — cases of bacteremia (bacteria in the bloodstream), sepsis, and other serious infections have been reported, though these are rare and usually happen in people whose bodies are already compromised.

You should check with your doctor before use. Fructooligosaccharide is generally well tolerated in food amounts but commonly causes gas, bloating, abdominal pain, and flatulence, especially at higher doses — though studies at doses under 10 grams a day show these effects don't increase compared to placebo.

We have limited safety data for the other ingredients at supplement levels, so professional guidance is wise. Pregnancy and lactation data for these ingredients aren't on file.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check with your pharmacist on timing — you'll want to separate them from this supplement by a few hours so the antibiotics don't kill off the live bacteria. Run your exact medications through the checker below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have IBS, recurrent antibiotic-related diarrhea, or bacterial vaginosis, this product may be worth considering with your doctor's input. Anyone taking antibiotics should time this supplement several hours apart.

Be ready for gas and bloating, especially when you first start. Talk to your pharmacist before you begin — especially if you're immunocompromised or taking any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Probiotic 40 Billion CFU, straight from the product label.

Brand eXplicit Supplements
Barcode (UPC) 711841905392
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 310023
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Probiotic 40 Billion CFU by eXplicit Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
711841905392
IngredientAmount% DV
Lactobacillus plantarum LP-1150 NP--
Lactobacillus acidophilus LA-140 NP--
Fructooligosaccharide0 NP--
MAKTREK Proprietary Blend of Probiotic Bacteria0 NP--
Lactobacillus paracasei LPC-370 NP--
Marine Polysaccharide Complex0 NP--
Bifidobacterium animalis lactis Bl-040 NP--

Other ingredients: Cellulose, Rice Maltodextrin, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Features MAKTREK Bi-Pass Technology Stomach protection & deliverability 20x more effective delivery

Advanced strength

Made with All Natural Ingredients No artificial flavors No preservatives

No soy, egg or dairy ingredients

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take two (2) capsules daily. Do not exceed two (2) capsules per day.

Precautions

Do not exceed two (2) capsules per day. Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Shelf stable

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Advanced Probiotic 40 Billion CFU active cultures

Seals/Symbols

Good Manufacturing Practice GMP FDA Registered Facility

Made in the USA

FDA Statement of Identity

Dietary Supplement

General Statements

Come check out our other products: www.explicitsupplements.com Facebook Twitter Instagram

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See for yourself

Advanced Probiotic 40 Billion CFU by eXplicit Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Probiotic 40 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Probiotic 40 Billion CFU by eXplicit Supplements

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

MAKTREK Proprietary Blend of Probiotic Bacteria

0 NP per serving

Other (inactive) ingredients: Cellulose, Rice Maltodextrin, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Probiotic 40 Billion CFU by eXplicit Supplements Drug Interactions

Want to check YOUR meds against Advanced Probiotic 40 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus LA-14 182

Individual Drug Interactions

The ingredients in Advanced Probiotic 40 Billion CFU interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Advanced Probiotic 40 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus LA-14

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Probiotic 40 Billion CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus LA-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus LA-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Probiotic 40 Billion CFU, from the product label.

eXplicit Supplements

See all eXplicit Supplements products
Name
iXanda Inc. dba explicit Supplements
City
Clarence
State
NY
ZipCode
14032
Phone Number
(716)-701-4092
Web Address
www.explicitsupplements.com
Pharmacist Counseling Corner

Advanced Probiotic 40 Billion CFU by eXplicit Supplements: Common Questions

Does Advanced Probiotic 40 Billion CFU by eXplicit Supplements interact with any medications?
Yes. Based on its ingredients, Advanced Probiotic 40 Billion CFU has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Probiotic 40 Billion CFU contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work if I'm taking antibiotics?
Probably not as well. Antibiotics kill bacteria — including the live L. acidophilus in this supplement. Your best bet is to take your antibiotic and this probiotic several hours apart, so the antibiotic has time to clear your system. Your pharmacist can help you space them out.
What side effects should I expect?
Gas, bloating, abdominal pain, and flatulence are the most common, especially when you start. These are often mild and can decrease over time. Rarely, some people in trials have reported rash or itching, though it's unclear if that was from the probiotic itself or another ingredient.
Is it safe to take this if I have a weak immune system?
That's a question for your doctor. Since this contains live organisms, there's a small theoretical risk of infection in people whose immune systems are compromised — it's rare, but it does happen. Check with them first.
Can I take this while pregnant or breastfeeding?
We don't have safety data on file for any of these ingredients during pregnancy or lactation. Talk with your doctor or pharmacist to see if it's right for you.
What is Fructooligosaccharide doing in here?
It's a prebiotic — a type of fiber that feeds the beneficial bacteria in the probiotic, helping them grow and thrive in your gut. However, the evidence for whether it actually works for constipation, cholesterol, or blood sugar isn't established yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Probiotic 40 Billion CFU is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Probiotic 40 Billion CFU label
Go deeper

The Full Monographs Behind Advanced Probiotic 40 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph →
Sources

Sources & How We Checked

Advanced Probiotic 40 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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