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Dietary supplement

AOX Defense Ingredients & Drug Interactions

by GNC AMP Advanced Muscle Performance

AOX Defense label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AOX Defense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

AOX Defense is a dietary supplement by GNC AMP Advanced Muscle Performance with 1 active ingredient. Its ingredients are commonly taken for vitamin c source, digestive upset, stress and relaxation (aromatherapy).Based on those ingredients, 246 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sicilian Blood Orange fruit and peel extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against AOX Defense by GNC AMP Advanced Muscle Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with AOX Defense by GNC AMP Advanced Muscle Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of AOX Defense by GNC AMP Advanced Muscle Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

AOX Defense has one active ingredient: Sicilian blood orange fruit and peel extract. The supplement also contains several inactive ingredients — microcrystalline cellulose, gelatin, maltodextrin, calcium silicate, magnesium stearate, silicon dioxide, and sodium lauryl sulfate — which are the binders, fillers, and capsule materials that hold the product together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sweet Orange's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: antioxidant defense against exercise-induced free radicals.
  • We looked for evidence on: Stress, muscle recovery, oxidative stress, exercise-induced inflammation.
  • The closest evidence on file: Sweet Orange is rated "Insufficient Reliable Evidence To Rate" for Stress (Natural Medicines).

The evidence we hold doesn't establish whether this blood orange extract works for any of the conditions listed on the label — pre-procedural anxiety, asthma, prostate cancer, common cold, constipation, or depression. All six carry a rating of insufficient reliable evidence to rate.

That doesn't mean it doesn't work; it means the clinical data we have isn't strong enough yet to say either way.

The evidence, ingredient by ingredient Sweet Orange

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sweet orange fruit and juice are safe as food for most people, but this product is a concentrated extract. Concentrated supplements and essential oils derived from sweet orange haven't been well studied, so the safety data is thinner than you'd have with the whole fruit.

There's one reported side effect: intestinal cramping in children who've had large amounts of orange peel — not common, but worth knowing.

Side effects, ingredient by ingredient Sweet Orange

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Orange.
  • The most serious interaction on file is rated Major.
  • For scale: 246 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take AOX Defense, check whether you're on any of these: pravastatin or other cholesterol drugs, OATP substrate medications (ask your pharmacist if yours is one), ivermectin, celiprolol or other beta-blockers, drugs that use P-glycoprotein for absorption, quinolone antibiotics like ciprofloxacin, or fexofenadine. All of these have Major or Moderate interactions with the blood orange extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

If you're thinking about this supplement, you really need to check your medication list first with the tool on this page. The blood orange extract in here interacts with a lot of drugs — cholesterol medications, antibiotics, beta-blockers, allergy drugs, and others.

If you take any of those or other prescription medications, talk to your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AOX Defense, straight from the product label.

Brand GNC AMP Advanced Muscle Performance
Net contents 30 Reddish-Filled Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 312700
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AOX Defense by GNC AMP Advanced Muscle Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Reddish-Filled Capsule(s)
Maximum serving Sizes:
1 Reddish-Filled Capsule(s)
Servings per container
30
IngredientAmount% DV
Sicilian Blood Orange fruit and peel extract100 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin, Maltodextrin, Calcium Silicate, Magnesium Stearate, Silicon Dioxide, Sodium Lauryl Sulfate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

5 products in 1 pack GNC AMP Men's Extreme Training Vitapak Program delivers the power of five science-based formulas to help you maximize your physical and mental intensity and get the most from your workout. Protect your muscles

Vitapak program with performance + endurance support

No artificial flavors, gluten free. Gluten free

Formula

Clinically researched antioxidants to defend against damaging free radicals caused by intense workouts

General Statements

If it's on our packages, then it's in our boxes. Clinically studied ingredients backed by real science. Get vitamins. Train Harder. Get extreme.

30-day supply

For more information: 1-888-462-2548 GNC.com Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find a replacement that is right for you.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take the contents of one pack daily with food.

Precautions

Warning: Cancer and reproductive harm - www.P65Warnings.ca.gov. Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition.

Discontinue use two weeks prior to surgery.

Keep out of reach of children

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AOX Defense by GNC AMP Advanced Muscle Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AOX Defense label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AOX Defense by GNC AMP Advanced Muscle Performance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Reddish-Filled Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Sicilian Blood Orange fruit and peel extract

Interacts with
246 drugs
100 mg per serving

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and es...

Sicilian Blood Orange fruit and peel extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Maltodextrin, Calcium Silicate, Magnesium Stearate, Silicon Dioxide, Sodium Lauryl Sulfate. These complete the product’s ingredient list but are not active constituents.

Interaction report

AOX Defense by GNC AMP Advanced Muscle Performance Drug Interactions

Want to check YOUR meds against AOX Defense?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
246Drugs
48 Major 198 Moderate

Ingredients driving the most interactions

Sicilian Blood Orange fruit and peel extract 246

Individual Drug Interactions

The ingredients in AOX Defense interact with 246 drugs. Click any drug to see the details.

1 of the 1 ingredient in AOX Defense interact with drugs. Each result below shows which ingredient is responsible. Sicilian Blood Orange fruit and peel extract

Each ingredient & the kinds of drugs it affects

For each ingredient in AOX Defense with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sicilian Blood Orange fruit and peel extract7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
Sicilian Blood Orange fruit and peel extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AOX Defense, from the product label.

GNC AMP Advanced Muscle Performance

See all GNC AMP Advanced Muscle Performance products
Name
GNC Holdings, LLC
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
GNC.com
Pharmacist Counseling Corner

AOX Defense by GNC AMP Advanced Muscle Performance: Common Questions

Does AOX Defense by GNC AMP Advanced Muscle Performance interact with any medications?
Yes. Based on its ingredients, AOX Defense has a known interaction with 246 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AOX Defense contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use while I'm pregnant or breastfeeding?
The data we have rates Sicilian blood orange as likely safe in pregnancy and lactation. But because this is a concentrated extract rather than whole fruit, it hasn't been studied as thoroughly as the food form. Talk with your OB or midwife to make sure it's right for your situation.
Can I just take this with food or water to avoid the interactions?
For some drugs, timing helps — the data mentions separating the supplement from certain medications by at least 4 hours. But that's not a fix-all. Some interactions (like with pravastatin) involve changes in how much drug your body absorbs, which timing alone may not solve. Your pharmacist can help you figure out what's safe.
What exactly is Sicilian blood orange extract, and why is it in this product?
It's a concentrated form of the fruit and peel from a specific orange variety grown in Sicily. The label suggests it's meant to help with things like anxiety, asthma, or colds, but the clinical evidence we have isn't strong enough to confirm it actually works for those uses.
Are there any side effects from the supplement itself?
The main one we've heard about is intestinal cramping in children who consume large amounts of orange peel. As a concentrated extract, it hasn't been studied as deeply as whole orange fruit, so we can't rule out other effects.
If I'm not on any of the medications you mentioned, is it safe for me?
The whole fruit and juice are safe for most people in normal amounts, but this is a concentrated extract with limited safety data. It's generally well tolerated, but concentrated forms and essential oils haven't been studied as thoroughly. If you have any health conditions or take supplements, check with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AOX Defense label
Go deeper

The Full Monographs Behind AOX Defense’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph →
Sources

Sources & How We Checked

AOX Defense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Orange 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
  3. Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
  4. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  5. Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
  6. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  7. Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
  8. Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. PubMed
  9. Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
  10. Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. PubMed
  11. Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. PubMed
  12. Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
  13. Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
  14. Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
  15. Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
  16. Kays MB, Overholser BR, Mueller BA, et al. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis. 2003;42(6):1253-9. PubMed
  17. Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI

See these in context on the Sweet Orange monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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