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Dietary supplement

Bitter Melon 1,000 mg Ingredients & Drug Interactions

by Herbal Secrets

Bitter Melon 1,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bitter Melon 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bitter Melon 1,000 mg is a dietary supplement by Herbal Secrets with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 283 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bitter Melon 1,000 mg by Herbal Secrets

Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon 1,000 mg by Herbal Secrets — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bitter Melon 1,000 mg by Herbal Secrets

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: bitter melon at 1,000 mg per capsule. Bitter melon is a tropical fruit used in traditional medicine, usually for its potential effects on blood sugar and digestion.

The capsule itself is filled out with inactive ingredients like cellulose, magnesium stearate, silicon dioxide, and microcrystalline cellulose—these are binders and fillers that help hold the capsule together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Bitter Melon product and its label doesn't state a use — see Bitter Melon's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for bitter melon isn't yet solid enough to rate. Our data shows insufficient reliable evidence to support its use for diabetes, constipation, liver disease, amenorrhea, athletic performance, or indigestion (dyspepsia).

That doesn't mean it doesn't work—it means we don't have enough high-quality studies to be confident either way. If you're thinking about taking it for one of these reasons, talk with your doctor about whether it's a good fit for you.

The evidence, ingredient by ingredient Bitter Melon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bitter melon is generally well tolerated when taken by mouth. The most common side effects are gastrointestinal—heartburn, nausea, vomiting, diarrhea, constipation, flatulence, and belly discomfort.

In clinical studies, these occurred in roughly 3 to 16 percent of people taking it. A small number of trial participants also reported dizziness, fatigue, or headache.

In rare cases, severe low blood sugar (hypoglycemic coma) and seizures in children have been reported. One case report described kidney inflammation after long-term use at high doses, which reversed when the supplement was stopped.

The safety data advises against bitter melon in pregnancy because seeds and high doses may cause harm. There isn't enough reliable information to know whether it's safe while breastfeeding—talk with your doctor or pharmacist if you're nursing.

Side effects, ingredient by ingredient Bitter Melon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bitter Melon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 283 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your doctor or pharmacist if you take antidiabetes drugs—there's a Moderate risk of low blood sugar. Also flag any P-glycoprotein substrate medications (certain cancer and heart drugs) and pazopanib (Votrient) in particular, as bitter melon may raise their levels and increase side effects.

Monitor blood glucose closely if you combine this with diabetes medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bitter melon may be worth considering if you're looking for a traditional herbal approach and your doctor thinks it's appropriate. However, be extra careful if you take diabetes medications or any cancer or heart drugs that depend on P-glycoprotein pumps—the interaction risk is real.

Watch for belly discomfort, nausea, and diarrhea, and avoid it in pregnancy. Check with your own doctor or pharmacist before starting, especially if you're on any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bitter Melon 1,000 mg, straight from the product label.

Brand Herbal Secrets
Barcode (UPC) 810180028653
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 313258
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bitter Melon 1,000 mg by Herbal Secrets, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
810180028653
IngredientAmount% DV
Bitter Melon1000 mg--

Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nature's best kept secret! At Herbal Secrets, we are committed to bringing you the gift of herbal supplements in their purest form, just as Mother Nature intended.

Visit us online @ amazingnutrition.com

Vitamin Angels proud supporter

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take two (2) veggie capsules twice daily, preferably with a meal or as directed by a healthcare professional.

Precautions

Caution: Not intended for use by persons under the age of 18, and pregnant or nursing women.

Caution: Not intended for use by persons under the age of 18, and pregnant or nursing women. If you are taking any medication, or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not use if safety seal is damaged or missing.

Keep out of reach of children.

Warning: This product can expose you to chemicals including lead, which is known to the state of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

100% natural

Contains no: Preservatives, artificial colors, flavors or sweeteners, sugar, milk, lactose, soy, gluten, wheat, yeast, fish, or sodium.

An FDA regulated facility

Seals/Symbols

Made in the USA

FDA Statement of Identity

Natural Dietary Supplement

Formula

Bitter Melon 1,000 mg per serving Momordica charantia

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bitter Melon 1,000 mg by Herbal Secrets label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bitter Melon 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bitter Melon 1,000 mg by Herbal Secrets

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Bitter Melon

Interacts with
283 drugs
1000 mg per serving

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...

Bitter Melon monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bitter Melon 1,000 mg by Herbal Secrets Drug Interactions

Want to check YOUR meds against Bitter Melon 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
283Drugs
283 Moderate

Ingredients driving the most interactions

Bitter Melon 283

Individual Drug Interactions

The ingredients in Bitter Melon 1,000 mg interact with 283 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bitter Melon 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon

Each ingredient & the kinds of drugs it affects

For each ingredient in Bitter Melon 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bitter Melon3 drug types · 283 drugs

Antidiabetes Drugs

Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Pazopanib (Votrient)

Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Bitter Melon full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bitter Melon 1,000 mg, from the product label.

Herbal Secrets

See all Herbal Secrets products
Name
Herbal Secrets
City
South Hackensack
State
NJ
ZipCode
07606
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Bitter Melon 1,000 mg by Herbal Secrets: Common Questions

Does Bitter Melon 1,000 mg by Herbal Secrets interact with any medications?
Yes. Based on its ingredients, Bitter Melon 1,000 mg has a known interaction with 283 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bitter Melon 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take diabetes medication?
Bitter melon lowers blood sugar on its own, so mixing it with diabetes drugs raises the risk of blood sugar going too low (hypoglycemia). If you take any diabetes medication—insulin, metformin, or any other kind—talk with your doctor before starting this supplement. You'd need to watch your blood glucose closely.
What side effects should I expect?
Most people who take bitter melon get mild stomach upset—heartburn, nausea, diarrhea, constipation, bloating, or belly discomfort. A small number also report dizziness, fatigue, or headache. These happened in roughly 3 to 16 percent of people in studies. Stop and call your doctor if you have severe belly pain or signs of very low blood sugar like shaking, sweating, or confusion.
Is there any evidence this actually works?
We don't have enough reliable studies yet to say bitter melon works for diabetes, constipation, liver disease, or other uses people try it for. That doesn't prove it doesn't work—just that the evidence isn't solid enough to be confident. Ask your doctor if it might still be worth trying for your situation.
Is it safe to take while pregnant or breastfeeding?
The safety data advises against bitter melon in pregnancy because seeds and high doses may cause harm. While breastfeeding, there isn't enough reliable information to know either way. If you're pregnant or nursing, talk with your doctor or pharmacist before taking this.
What exactly is bitter melon?
Bitter melon is a tropical fruit that looks like a bumpy cucumber. It's used in cooking in some cultures and in traditional medicine. This supplement contains the whole plant material at 1,000 mg per capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bitter Melon 1,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bitter Melon 1,000 mg label
Go deeper

The Full Monographs Behind Bitter Melon 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bitter Melon

Interacts with 283 drugs

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it may modestly lower blood sugar, the evid...

Read the full Bitter Melon monograph →
Sources

Sources & How We Checked

Bitter Melon 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bitter Melon 18 references
  1. Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
  2. Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
  3. Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
  4. Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
  5. Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
  6. Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
  7. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
  8. Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
  9. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
  10. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
  11. Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
  12. Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
  13. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
  14. Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
  15. Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
  16. Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
  17. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  18. Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed

See these in context on the Bitter Melon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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