Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Boldo Ingredients & Drug Interactions

by Amazon Therapeutics

Boldo label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boldo against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boldo is a dietary supplement by Amazon Therapeutics with 3 active ingredients. Its ingredients are commonly taken for indigestion and bloating, mild constipation, liver and gallbladder support.Based on those ingredients, 482 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 100% Boldo. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Boldo by Amazon Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Boldo by Amazon Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Boldo by Amazon Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

This liquid supplement contains 3 ingredients: distilled water, 35–40% organic alcohol (the carrier), and 100% boldo leaf extract. The alcohol serves as a preservative and delivery system for the boldo, which is the active ingredient.

Boldo has been used traditionally for gallbladder and digestive support, though the evidence for these uses in our data is rated insufficient to draw firm conclusions.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Boldo product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Boldo's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“Digestion support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence we hold on boldo doesn't support its use for any condition yet. Its traditional uses include benign prostatic hyperplasia (enlarged prostate), gallbladder disease, kidney stones, and joint pain — but for all of these, we rate the evidence as insufficient to know if it actually works.

The evidence, ingredient by ingredient Boldo

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When boldo is used in food-level amounts, it's generally well tolerated. In medicinal doses like those in a supplement, it carries real risks.

The most serious is liver damage (hepatotoxicity) — boldo's volatile oil contains ascaridole, a liver toxin. Common side effects at higher doses are abdominal pain, nausea, and vomiting.

Cases in the medical literature document people who developed elevated liver enzymes, jaundice, and gastrointestinal upset after taking boldo, with symptoms resolving when they stopped. Boldo is considered possibly unsafe in pregnancy because it may stimulate the uterus.

There isn't enough safety data to support use while breastfeeding — talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Boldo

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boldo.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; lithium.
  • For scale: 483 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check any medications that can damage the liver, blood thinners (anticoagulants or antiplatelets) like warfarin, lithium, or tacrolimus. All have Moderate interactions with boldo documented in our data.

If you're on any of these, talk to your pharmacist first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Boldo is a traditional herbal remedy, but the evidence for what it treats isn't established in our data, and the safety profile — especially liver risk — is a real concern. If you take any blood thinners, lithium, tacrolimus, or drugs that stress your liver, check with your pharmacist before starting.

Pregnant and nursing people should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boldo, straight from the product label.

Brand Amazon Therapeutics
Barcode (UPC) 838451002010
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217633
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boldo by Amazon Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
15 Drop(s)
UPC/BARCODE
838451002010
IngredientAmount% DV
distilled Water0 NP--
35-40% organic Alcohol0 NP--
100% Boldo0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Your Selection You hold in your hands the finest traditional botanical available. This botanical is a long-standing favorite in South America where it has been empirically selected for its effectiveness over many generations.

Digestion support

Supports natural functions Wild crafted sustainable harvest

Gluten free

Suggested/Recommended/Usage/Directions

Suggested Directions Use 10-15 drops once or twice a day in water or as recommended by a health care practitioner.

Precautions

Cautions: Information provided on this label should not be used as medical advice. Not intended for long-term use.

Not intended for pregnant or nursing women.

Keep out of the reach of children.

Formula

Peumus boldus

EarthKosher

FDA Statement of Identity

Dietary Supplement

General Statements

Traditional ethnobotanical information Amazon Therapeutics works for the preservation of rainforests and to uphold the intellectual property rights of native healers and their traditional medicines.

Seals/Symbols

EarthKosher

FDA Disclaimer Statement

This statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boldo by Amazon Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boldo label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boldo by Amazon Therapeutics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Distilled Water

0 NP per serving

35-40% organic Alcohol

0 NP per serving

100% Boldo

Interacts with
482 drugs
0 NP per serving

Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited....

100% Boldo monograph & interactions
Interaction report

Boldo by Amazon Therapeutics Drug Interactions

Want to check YOUR meds against Boldo?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
482Drugs
482 Moderate

Ingredients driving the most interactions

100% Boldo 482

Individual Drug Interactions

The ingredients in Boldo interact with 482 drugs. Click any drug to see the details.

1 of the 3 ingredients in Boldo interact with drugs. Each result below shows which ingredient is responsible. 100% Boldo

Each ingredient & the kinds of drugs it affects

For each ingredient in Boldo with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

100% Boldo5 drug types · 482 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Animal and in vitro research shows that boldine, a constituent of boldo, has antiplatelet activity. In one case report, an adult taking a combination of boldo and fenugreek with warfarin experienced an increase in international normalized ratio (INR); however, it is unclear if this effect was due to boldo, fenugreek, the combination, or another factor.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Boldo leaf contains ascaridole, a known liver toxin. Many cases of hepatotoxicity, including elevated liver transaminase levels and jaundice, have been reported in patients taking boldo.

Likelihood Possible Evidence D
Lithium

Theoretically, taking boldo with lithium might increase the levels and clinical effects of lithium.
Boldo is believed to have diuretic effects. Theoretically, these diuretic effects might reduce the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tacrolimus (Prograf)

Taking boldo with tacrolimus may decrease the levels and clinical effects of tacrolimus, potentially increasing the risk of transplant rejection.
In one case report, a patient with a long-term history of stable tacrolimus levels developed subtherapeutic levels after taking boldo 300 mg twice daily orally for several weeks. Tacrolimus levels returned to normal after discontinuing boldo. However, the mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Warfarin (Coumadin)

A combination of boldo and fenugreek was thought to be associated with an increased international normalized ratio (INR) in a female on warfarin. It is not clear if boldo, fenugreek, or the combination played a role in this interaction. Therefore, boldo may have additive effects with warfarin.

Likelihood Possible Evidence D
100% Boldo full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boldo, from the product label.

Amazon Therapeutics

See all Amazon Therapeutics products
Name
Herbs America
Street Address
PO Box 446
City
Murphy
State
OR
ZipCode
97533
Phone Number
541-846-6222
Web Address
www.amazonmedicine.com
Pharmacist Counseling Corner

Boldo by Amazon Therapeutics: Common Questions

Does Boldo by Amazon Therapeutics interact with any medications?
Yes. Based on its ingredients, Boldo has a known interaction with 482 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boldo contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is boldo safe to take long-term?
No. The safety data advises short-term use in low doses only. Boldo contains ascaridole, a liver toxin, and cases of liver damage have been reported — including elevated liver enzymes and jaundice. Long-term use isn't recommended.
What are the most common side effects?
At medicinal doses, abdominal pain, nausea, and vomiting are the most common. Severe liver damage (hepatotoxicity) is rare but documented. If you develop yellowing of the skin or eyes, dark urine, or persistent nausea after starting boldo, stop and contact your doctor.
Can I take boldo if I'm pregnant or breastfeeding?
No. Boldo is considered possibly unsafe in pregnancy because it may stimulate the uterus. There isn't enough safety data to support use while breastfeeding. Talk with your doctor or pharmacist before considering it if you're pregnant or nursing.
What is boldo actually used for?
Traditionally, boldo has been used for gallbladder disease, kidney stones, prostate problems, and joint pain. However, the evidence we hold on these uses is rated insufficient — we don't have reliable data yet that it works for any of them.
Why does this supplement contain alcohol?
The alcohol (35–40%) is the carrier liquid that preserves the boldo extract and helps deliver it. It's a common way to make herbal liquid supplements, though it does mean the product contains a significant amount of alcohol by volume.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boldo label
Go deeper

The Full Monographs Behind Boldo’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boldo

Interacts with 482 drugs

Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole,...

Read the full Boldo monograph →
Sources

Sources & How We Checked

Boldo's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boldo 10 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
  3. Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
  4. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  5. Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
  6. Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
  7. Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
  8. Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
  9. Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
  10. Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed

See these in context on the Boldo monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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