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Dietary supplement

BroccoProtect Ingredients & Drug Interactions

by Designs for Health

BroccoProtect label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BroccoProtect against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

BroccoProtect is a dietary supplement by Designs for Health with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BroccoRaphanin(R). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BroccoProtect by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with BroccoProtect by Designs for Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of BroccoProtect by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

BroccoProtect is a single-ingredient supplement containing BroccoRaphanin®, a concentrated extract of broccoli. This ingredient delivers broccoli's active compounds, primarily glucosinolates, in capsule form.

The product also contains inactive ingredients — microcrystalline cellulose, rice flour, and vegetable stearate — which are binders, fillers, and anti-caking agents that help hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Broccoli's overall clinical evidence instead.

Moderate

Some clinical evidence supports Broccoli for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Colorectal cancer — rated "Possibly Effective" (Natural Medicines).

Broccoli extract is possibly effective for colorectal cancer prevention based on the evidence we hold. For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, the evidence isn't strong enough to rate it either way — more research is needed to know whether it helps.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a whole food is safe for most people in normal amounts. However, concentrated broccoli supplements like this one are less studied, and the safety data we hold advises caution — concentrated extracts haven't been as thoroughly tested as the food itself.

You should talk with your doctor before taking this product to make sure it's right for you. Side effects reported with broccoli seed and sprout extracts include loose stools, diarrhea, belly pain, and cramping, especially at higher doses.

A small number of people have also had allergic contact reactions to broccoli on the skin.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take BroccoProtect, check with your doctor or pharmacist if you take any medications metabolized by the CYP2A6 or CYP1A2 pathways — broccoli can significantly reduce their blood levels and effectiveness. This is especially important if you're on a medication where dose precision matters.

Use the medication checker on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

BroccoProtect may be worth considering if you're interested in broccoli's potential benefits for colorectal cancer and you've checked it with your doctor or pharmacist. However, it interacts significantly with many common medications by speeding up how your liver breaks them down — so if you take any prescription drugs, you'll need to confirm it's safe with your own healthcare provider before you start.

Concentrated broccoli extracts are less well-studied than the food itself, so erring on the side of caution makes sense.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BroccoProtect, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452002753
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22344
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BroccoProtect by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
879452002753
IngredientAmount% DV
BroccoRaphanin(R)500 mg--

Other ingredients: Microcrystalline Cellulose, Rice Flour, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

NOTICE: Color, size or shape may appear different between lots.

Manufactured in an NSF GMP Registered Facility

For Professional Use Only

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule per day with water, or as directed by your health care practitioner.

Seals/Symbols

Guaranteed GMP COMPLAINT Products

Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Formulation

Does not contain gluten.

General

BPT090

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

BroccoRaphanin(R) is a registered trademark of CS Health.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BroccoProtect by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BroccoProtect label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BroccoProtect by Designs for Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

BroccoRaphanin(R)

Interacts with
187 drugs
500 mg per serving Form: Sulforaphane Glucosinolate

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

BroccoRaphanin(R) monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Rice Flour, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

BroccoProtect by Designs for Health Drug Interactions

Want to check YOUR meds against BroccoProtect?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

BroccoRaphanin(R) 187

Individual Drug Interactions

The ingredients in BroccoProtect interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in BroccoProtect interact with drugs. Each result below shows which ingredient is responsible. BroccoRaphanin(R)

Each ingredient & the kinds of drugs it affects

For each ingredient in BroccoProtect with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BroccoRaphanin(R)2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
BroccoRaphanin(R) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BroccoProtect, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

BroccoProtect by Designs for Health: Common Questions

Does BroccoProtect by Designs for Health interact with any medications?
Yes. Based on its ingredients, BroccoProtect has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BroccoProtect contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is BroccoProtect safe to take during pregnancy or while breastfeeding?
According to the safety data we hold, broccoli as food is likely safe during pregnancy and lactation. However, concentrated supplements haven't been studied as thoroughly, and the safety rating applies to the food itself rather than the extract. Talk with your doctor or pharmacist about whether this particular supplement is right for you during pregnancy or breastfeeding.
What is BroccoRaphanin®, and why is it in this product?
BroccoRaphanin® is a concentrated extract of broccoli that delivers the plant's active compounds, mainly glucosinolates. It's included because these compounds are thought to be responsible for broccoli's health benefits — including its possibly effective role in colorectal cancer prevention.
Can BroccoProtect help prevent cancer?
Broccoli extract is possibly effective for colorectal cancer based on our data. For bladder, breast, and gastric cancers, the evidence isn't solid enough to say whether it helps or doesn't. Talk with your doctor about whether this supplement fits into your overall health plan.
What side effects might I experience from taking BroccoProtect?
The most common side effects reported with broccoli seed and sprout extracts are loose stools, diarrhea, belly pain, and cramping — particularly at higher doses. Allergic skin reactions to broccoli itself have also been reported, though they're less common.
Is this supplement different from just eating broccoli?
Yes — BroccoProtect is a concentrated extract, whereas fresh broccoli is a whole food. Concentrated supplements are less studied for safety than the food itself, which is why caution is advised. They may also have a stronger or faster effect on how your liver processes medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BroccoProtect label
Go deeper

The Full Monographs Behind BroccoProtect’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

BroccoProtect's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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