CBD Oil 6% Ingredients & Drug Interactions
by SuperSmart
What is this page for?
First and foremost: checking CBD Oil 6% against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CBD Oil 6% is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are non psychotropic Hemp Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against CBD Oil 6% by SuperSmart
Ask about any prescription or over-the-counter medication and we check it for interactions with CBD Oil 6% by SuperSmart — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of CBD Oil 6% by SuperSmart
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has one active ingredient: cannabidiol (CBD), the non-intoxicating compound from hemp. It's formulated as a 6% CBD oil in softgel capsules.
The only other ingredient listed is olive oil, which serves as a carrier and filler.
Does it work?
Couldn't assess
We don't have evidence in our data that CBD or hemp oil is effective for constipation, eczema (atopic dermatitis), or familial hypercholesterolemia. The evidence we hold for these uses is rated insufficient — meaning it hasn't been established well enough to make a reliable claim.
If you're considering this product for a specific health concern, talk with your pharmacist or doctor about what the current research actually supports.
How safe is it?
Well-documented data
Hemp seed foods in normal dietary amounts are generally well tolerated. However, concentrated supplements and extracts like this one are less studied for safety.
Serious side effects are rare, but case reports include allergic reactions (hives, facial swelling, shortness of breath, and anaphylaxis in people with hemp seed allergy), heart rhythm problems (long QT syndrome and syncope), and in one young child given very high doses of hemp extract, elevated liver enzymes and hepatitis. Allergy to hemp seed is uncommon but can occur even on first exposure.
Meds to double-check
Moderate interaction found
Check your medications against this product if you take estrogens (hormone therapy — Moderate severity), antihypertensive or ACE inhibitor blood pressure drugs, anticoagulants or antiplatelet agents (blood thinners), or drugs processed by your liver through the CYP1A2 or CYP3A4 pathways. Altogether, these interactions span 927 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you're on estrogen therapy, blood pressure medication, blood thinners, or drugs metabolized through your liver's CYP1A2 or CYP3A4 pathways, check this product against your medications before starting. If you have a known hemp or cannabis seed allergy, avoid it.
For everyone else, talk with your pharmacist about whether this product is right for your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CBD Oil 6%, straight from the product label.
| Brand | SuperSmart |
|---|---|
| Barcode (UPC) | 5453003827610 |
| Net contents | 30 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2021 |
| DSLD ID | 250678 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CBD Oil 6% by SuperSmart, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cannabidiol | 10 mg | -- |
| non psychotropic Hemp Oil | 156.25 mg | -- |
Other ingredients: Olive Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Full spectrum
This supplement contains no psychotropic substance.
FDA Statement of Identity
Dietary Supplement
Formula
10 mg per day
Each softgel contains 78,125 mg hemp oil standardised to 6.4% cannabidiol (CBD) ie 5 mg of CBD.
Suggested/Recommended/Usage/Directions
Recommended Use: Adults. Take 2 softgels a day.
Precautions
Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.
Keep out of childrens' reach.
As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
Storage
Store away from direct light, heat and humidity.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CBD Oil 6% by SuperSmart label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CBD Oil 6% by SuperSmart
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container15 Amounts shown are per serving.
Cannabidiol
Other (inactive) ingredients: Olive Oil. These complete the product’s ingredient list but are not active constituents.
CBD Oil 6% by SuperSmart Drug Interactions
HelloPharmacist Interaction Report
SuperSmart CBD Oil 6% contains cannabidiol and non-psychotropic hemp oil.
The hemp oil component has documented interactions with several medication types.
Read the full breakdown — every affected drug type, severity by severity
The most serious concern is with estrogens (hormone therapy). Hemp oil may theoretically interfere with how your body handles these hormones, based on animal research showing it can affect estradiol levels, though the exact mechanism isn't clear.
This is a Moderate severity interaction.
Minor interactions are documented with blood pressure medications (antihypertensives and ACE inhibitors — hemp seed protein may add to their blood-pressure-lowering effect), blood thinners (anticoagulants and antiplatelet drugs — hemp seed might increase bleeding risk, though human data is limited), and certain drugs your liver metabolizes via CYP1A2 and CYP3A4 enzyme pathways (hemp may speed up their clearance and reduce their effectiveness).
We were unable to check cannabidiol itself — our data treat it as a blend container pointing to its individual components. Use the medication checker on this page to search your exact prescriptions against these interactions.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against CBD Oil 6%?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in CBD Oil 6% interact with 938 drugs. Click any drug to see the details.
1 of the 1 ingredient in CBD Oil 6% interact with drugs. Each result below shows which ingredient is responsible. non psychotropic Hemp Oil
Bazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Bazedoxifene Acetate, Conjugated Estrogens interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Conjugated Estrogens, Methyltestosterone interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Cyproterone Acetate, Ethinyl Estradiol interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Desogestrel, Ethinyl Estradiol interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Non Psychotropic Hemp Oil + Drospirenone, Ethinyl Estradiol interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Non Psychotropic Hemp Oil + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Ethiny Estradiol, Levonorgestrel interactionEthinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with CBD Oil 6% — through 1 ingredient. Tap an ingredient for the detail:
Non Psychotropic Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Non Psychotropic Hemp Oil + Ethinyl Estradiol, Levonogestrel interactionEach ingredient & the kinds of drugs it affects
For each ingredient in CBD Oil 6% with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
non psychotropic Hemp Oil
Estrogens
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.
Ace Inhibitors (Aceis)
Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Anticoagulant/Antiplatelet Drugs
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.
Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Brand information
Manufacturer and brand details for CBD Oil 6%, from the product label.
SuperSmart
See all SuperSmart products- Name
- SN Worldwide Unipessoal, Lda
- Street Address
- Avenida Do Infante 66, Edificio Quinta Avenida 1 C
- City
- Funchal
- ZipCode
- 9000-015
CBD Oil 6% by SuperSmart: Common Questions
Does CBD Oil 6% by SuperSmart interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm allergic to hemp seed?
What side effects might I notice?
Is it safe to take during pregnancy or breastfeeding?
Does this actually work for what I want to take it for?
Why does the data say 'concentrated extracts are less studied'?
Should I be worried about the 927 medications listed?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CBD Oil 6% is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CBD Oil 6%’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
CBD Oil 6%'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hemp 12 references
- Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
- Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
- Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
- Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
- Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
- Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
- Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
- Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
- Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
- Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
- Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC