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Dietary supplement

Centella Asiatica 180 mg Ingredients & Drug Interactions

by SuperSmart

Centella Asiatica 180 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Centella Asiatica 180 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Centella Asiatica 180 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for wound healing, varicose veins and poor circulation, anxiety and stress.Based on those ingredients, 579 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Centella asiatica. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Centella Asiatica 180 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Centella Asiatica 180 mg by SuperSmart — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Centella Asiatica 180 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: centella asiatica (also called gotu kola), at 180 mg per capsule. It's added to acacia gum and white rice flour, which are inactive ingredients that help form and fill the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Gotu Kola's overall clinical evidence instead.

Moderate

Some clinical evidence supports Gotu Kola for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Burns — rated "Possibly Effective" (Natural Medicines).
  • On file: Venous insufficiency — rated "Possibly Effective" (Natural Medicines).

The evidence for gotu kola is mixed and depends on what you're using it for. It's possibly effective for venous insufficiency (poor circulation in the legs) and for burns.

For radiation dermatitis, cognitive function, and Alzheimer's disease, the evidence doesn't support benefit or is too limited to say. If you're considering this for a specific condition, talk with your pharmacist about what the research actually shows for your situation.

The evidence, ingredient by ingredient Gotu Kola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gotu kola is generally well tolerated when taken by mouth, though quality long-term data is sparse. The most common side effects are mild — gastric irritation and nausea.

The main concern is liver toxicity, which is rare; a 6-month trial at 120 mg daily saw no liver function changes, but case reports exist and caution is warranted. During pregnancy, there isn't enough safety data, and it's traditionally been avoided — talk with your doctor or pharmacist before use.

Breastfeeding safety is unknown, so it's best avoided if you're nursing.

Side effects, ingredient by ingredient Gotu Kola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gotu Kola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 580 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting, check your exact medications against these two drug types: CNS depressants (sedatives, sleep aids, pain relievers that make you drowsy) and hepatotoxic drugs (medications that can stress the liver). Both carry Moderate-severity interaction risks with gotu kola.

Use the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Gotu kola may help with circulation or wound healing, but the evidence is modest and mixed. If you take CNS depressants or any medication that affects the liver, you'll want to check with us first.

Pregnant or breastfeeding? Skip it unless your doctor gives the all-clear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Centella Asiatica 180 mg, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003824046
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 285304
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Centella Asiatica 180 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
5453003824046
IngredientAmount% DV
Centella asiatica180 mg--

Other ingredients: Acacia Gum, White Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Ayurvedic herb

FDA Statement of Identity

Dietary Supplement

Formula

Centella Asiatica 180 mg per day

Each vegetarian capsule contains 60 mg of Centella asiatica.

Suggested/Recommended/Usage/Directions

Recommended Use: Adults. Take between one and three capsules a day with meals.

Precautions

Precautions: Do not exceed the maximum recommended daily dose. Food supplements should not be used as a substitute for a varied diet.

Store out of reach of young children.

As with any food supplement, always consult your healthcare professional before consuming if you are pregnant, lactating or if you have any other health condition.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Centella Asiatica 180 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Centella Asiatica 180 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Centella Asiatica 180 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Centella asiatica

Interacts with
579 drugs
180 mg per serving Form: Asiaticosides, Madecassosides

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Centella asiatica monograph & interactions

Other (inactive) ingredients: Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Centella Asiatica 180 mg by SuperSmart Drug Interactions

Want to check YOUR meds against Centella Asiatica 180 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
579Drugs
579 Moderate

Ingredients driving the most interactions

Centella asiatica 579

Individual Drug Interactions

The ingredients in Centella Asiatica 180 mg interact with 579 drugs. Click any drug to see the details.

1 of the 1 ingredient in Centella Asiatica 180 mg interact with drugs. Each result below shows which ingredient is responsible. Centella asiatica

Each ingredient & the kinds of drugs it affects

For each ingredient in Centella Asiatica 180 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Centella asiatica2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Centella asiatica full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Centella Asiatica 180 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, LDA
Street Address
Avenida Do Infante 66 Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Centella Asiatica 180 mg by SuperSmart: Common Questions

Does Centella Asiatica 180 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, Centella Asiatica 180 mg has a known interaction with 579 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Centella Asiatica 180 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is gotu kola safe during pregnancy?
The safety data isn't there yet, and it's traditionally been avoided in pregnancy. Talk with your doctor or pharmacist before taking it — they can give you personalized advice based on your health.
Can I take this while breastfeeding?
Safety during breastfeeding isn't known, so it's best to avoid it. Check with your doctor or pharmacist if you're nursing.
What are the most common side effects?
When taken by mouth, gotu kola most often causes mild stomach irritation and nausea. These aren't serious, but if they bother you, let your pharmacist know.
Can gotu kola really damage the liver?
There are four case reports of liver damage linked to gotu kola, but it's not clear whether gotu kola actually caused it — the products weren't tested for contaminants and doses weren't recorded. A clinical trial at 120 mg daily for 6 months showed no liver function changes, so it's rare. That said, if you have liver problems or take medications that affect the liver, mention this supplement to your pharmacist first.
Does gotu kola really work for anxiety?
There isn't enough reliable evidence yet to say whether it helps anxiety. If anxiety is something you're dealing with, talk with your doctor about what's proven to work.
Will this help my circulation or wound healing?
For circulation problems in the legs (venous insufficiency), gotu kola is possibly effective. For burns, it's also possibly effective. For other skin or circulation issues, the evidence is weaker or absent, so ask your pharmacist whether it's right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Centella Asiatica 180 mg label
Go deeper

The Full Monographs Behind Centella Asiatica 180 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph →
Sources

Sources & How We Checked

Centella Asiatica 180 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.
  16. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.
  17. Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436.
  18. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed

See these in context on the Gotu Kola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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