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Dietary supplement

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU Ingredients & Drug Interactions

by Bronson

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU is a dietary supplement by Bronson with 1 active ingredient. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Saccharomyces boulardii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson

Ask about any prescription or over-the-counter medication and we check it for interactions with Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Saccharomyces boulardii, a live yeast strain with 20 billion colony-forming units (CFU) per capsule. It also includes inactive ingredients—modified cellulose, rice bran extract, magnesium stearate, and silicon dioxide—which are fillers and binders that help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy immunity and digestion.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Travelers' diarrhea, Rotaviral diarrhea, Crohn disease, Ulcerative colitis — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Saccharomyces Boulardii is rated "Insufficient Reliable Evidence To Rate" for Constipation, Crohn disease, Ulcerative colitis.

Saccharomyces boulardii is possibly effective for several types of diarrhea: rotaviral diarrhea (the kind rotavirus causes), travelers' diarrhea, and antibiotic-associated diarrhea. The evidence also suggests it may be possibly effective for necrotizing enterocolitis (a serious intestinal condition in newborns), Clostridioides difficile infection (a tough-to-treat bacterial infection), and Helicobacter pylori (a stomach bacterium).

These ratings mean there is some supporting research, but more study would strengthen the evidence.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saccharomyces boulardii is generally well tolerated in healthy adults, but it should be avoided if you are critically ill or immunocompromised (have a weakened immune system). Limited safety data are available overall, so talk with your doctor before using it.

Rarely, this probiotic has caused fungemia (a yeast infection in the bloodstream), particularly in critically ill patients in the ICU with central catheters, those on feeding tubes, or those on broad-spectrum antibiotics. Occasional side effects include abdominal cramps, gas, nausea, vomiting, and loss of appetite.

Safety in pregnancy and lactation is not established in the data we hold—speak with your doctor for personalized guidance.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this probiotic, double-check with your doctor or pharmacist if you take antifungals. Since Saccharomyces boulardii is a live yeast, antifungals may reduce the probiotic's effectiveness by killing the organisms.

If no interactions are documented in our data for your other medications, that doesn't guarantee none exist—confirm your full medication list with your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This probiotic may help with certain types of diarrhea, especially traveler's diarrhea and diarrhea caused by antibiotics. If you're healthy, it's generally well tolerated, but skip it if you're critically ill or have a compromised immune system.

Talk with your doctor or pharmacist before starting, especially if you take antifungals or have other health concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU, straight from the product label.

Brand Bronson
Barcode (UPC) X000WYYEDJ
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 233101
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
X000WYYEDJ
IngredientAmount% DV
Saccharomyces boulardii0 NP--

Other ingredients: Modified Cellulose, Rice Bran extract, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bronson Nutrition+ since 1960

60 Count

365 day 100% money back guaranteed Nutrition Questions or Comments? [email protected] Call 1-800-235-3200 Mon. - Fri. 7 AM - 6 PM MST Sat. 8 AM - 4:30 PM MST New

Formulation

Supports healthy immunity function Promotes digestion and gut health

Gluten-free Soy-free

Proprietary strain

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take 2 capsules daily, preferably with food or as recommended by a healthcare professional.

Precautions

Warning: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Lab Tested Made from High Quality Ingredients GMP Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Saccharomyces boulardii

Interacts with
40 drugs
0 NP per serving

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii monograph & interactions

Other (inactive) ingredients: Modified Cellulose, Rice Bran extract, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson Drug Interactions

Want to check YOUR meds against Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

Saccharomyces boulardii 40

Individual Drug Interactions

The ingredients in Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU, from the product label.

Bronson

Name
Bronson Laboratories
Street Address
70 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
1-800-235-3200
Web Address
BronsonVitamins.com
Pharmacist Counseling Corner

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson: Common Questions

Does Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU by Bronson interact with any medications?
Yes. Based on its ingredients, Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Saccharomyces boulardii, and how does it work?
Saccharomyces boulardii is a live yeast that acts as a probiotic—a beneficial microorganism. It's thought to help restore healthy gut bacteria, especially after antibiotics have disrupted your intestinal flora or when you have certain types of diarrhea.
Can I take this if I'm on an antifungal medication?
You can, but timing matters. Antifungals kill fungal organisms, including the live yeast in this supplement, so they may reduce how well the probiotic works. Talk to your doctor or pharmacist about the best way to take them—they may suggest spacing them out during the day.
Is this safe for everyone?
It's generally safe for healthy adults, but you should avoid it if you're critically ill, immunocompromised, or have a central venous catheter. Limited safety data exist overall, so check with your doctor before starting, especially if you have a serious health condition.
What side effects might I experience?
Most people tolerate it well. Rarely, it causes gastrointestinal complaints like abdominal cramps, gas, nausea, vomiting, or loss of appetite. In very rare cases, particularly in critically ill patients, it has caused fungemia (a yeast infection in the bloodstream).
Does this work for travelers' diarrhea?
Yes, it's possibly effective for travelers' diarrhea according to the available evidence. It's also possibly effective for antibiotic-associated diarrhea and several other types of diarrhea caused by rotavirus or C. difficile.
Is it safe to take while pregnant or breastfeeding?
We don't have enough safety data to say either way. Talk with your doctor or pharmacist before using this product if you're pregnant or breastfeeding—they can give you personalized advice based on your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU label
Go deeper

The Full Monographs Behind Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

Clinically Tested Probiotic Saccharomyces Boulardii 20 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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