Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

CoQ10 Plus Ingredients & Drug Interactions

by Herbalife Nutrition

CoQ10 Plus label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CoQ10 Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

CoQ10 Plus is a dietary supplement by Herbalife Nutrition with 4 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 911 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin D, Coenzyme Q-10, Hawthorn fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CoQ10 Plus by Herbalife Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with CoQ10 Plus by Herbalife Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of CoQ10 Plus by Herbalife Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

CoQ10 Plus contains four active ingredients. Vitamin D supports bone health and calcium regulation.

Docosahexaenoic acid is an omega-3 fatty acid that plays a role in heart and brain function. Coenzyme Q10 is an antioxidant your body makes naturally and uses for energy production in cells.

Hawthorn fruit extract has been traditionally used to support cardiovascular function. The product also contains several inactive ingredients — sesame oil, gelatin, glycerin, and others — that serve as the capsule structure and add texture or flavor.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Energy for the heart.
  • We looked for evidence on: Angina, Arrhythmia, Atrial fibrillation, Cardiovascular disease (CVD), Coenzyme Q10 deficiency, Congestive heart failure (CHF) — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Likely Effective" for Coenzyme Q10 deficiency (Natural Medicines).
  • Also on file: Vitamin D is rated "Possibly Effective" for Heart failure.
  • Also on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF).

Vitamin D is effective for treating familial hypophosphatemia, osteomalacia (soft bones), renal osteodystrophy, rickets, and hypoparathyroidism. Coenzyme Q10 is likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraine headache, congestive heart failure, and diabetic nerve pain.

For hawthorn, the evidence we hold does not establish reliable effectiveness for angina, anxiety, arrhythmia, atherosclerosis, cardiovascular disease, or cognitive function. We have no effectiveness data on file for docosahexaenoic acid.

The evidence, ingredient by ingredient Vitamin D Coenzyme Q10 Hawthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, though very high doses taken over time can cause toxicity with symptoms like high blood calcium levels. It's often used during pregnancy and breastfeeding at recommended amounts, but only under doctor guidance.

Coenzyme Q10 is generally well tolerated; the most common side effects are mild gastrointestinal issues like nausea, diarrhea, or heartburn in less than 1% of patients, and headache or dizziness have been reported rarely. There is not enough safety data for CoQ10 in pregnancy, and breastfeeding safety has not been well studied — check with your doctor.

Hawthorn is generally well tolerated in studies but requires medical supervision if you have a heart condition. Safety data for hawthorn in pregnancy and breastfeeding is insufficient — avoid use unless your doctor advises otherwise.

Side effects, ingredient by ingredient Vitamin D Coenzyme Q10 Hawthorn

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Hawthorn, Vitamin D, Coenzyme Q10.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 912 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product before starting, especially: nitrates and PDE-5 inhibitors like sildenafil (Viagra) — both carry Major-severity risks with hawthorn. Moderate-severity cautions apply to blood thinners like warfarin, heart medications including verapamil, diltiazem, digoxin, beta-blockers, and calcium channel blockers, blood pressure drugs in general, chemotherapy drugs, and thiazide water pills.

High-dose vitamin D also affects atorvastatin absorption and aluminum-based antacids.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

CoQ10 Plus may appeal to you if you want to support heart health and have a CoQ10 deficiency or migraine concerns, and if you need vitamin D supplementation under medical supervision. Be especially cautious if you take nitrates, PDE-5 inhibitors (like sildenafil), warfarin, digoxin, or any heart rhythm medication.

Talk to your pharmacist or doctor before adding this to your routine — the interactions here are real and worth a conversation about your exact medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CoQ10 Plus, straight from the product label.

Brand Herbalife Nutrition
Barcode (UPC) 1500US
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 309639
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CoQ10 Plus by Herbalife Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
1500US
IngredientAmount% DV
Calories5 Calorie(s)--
Vitamin D15 mcg75%
Docosahexaenoic Acid100 mg--
Coenzyme Q-10100 mg--
Hawthorn fruit extract30 mg--

Other ingredients: Sesame Oil, Gelatin, Water, Glycerin, Glyceryl Monooleate, Peppermint Oil, Silicon Dioxide, Annatto, Soy Lecithin, Titanium Dioxide, Ethyl Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Energy for the heart

Made in Canada

CoQ10 provides energy to heart cells, supports the muscle, and protects cells from the damaging effects of oxidative stress. This excellent source of vitamin D provides additional heart health support.

FDA Statement of Identity

Dietary Supplement

General Statements

Louis J. Ignarro Exclusively endorsed by Dr. Lou Ignarro, Nobel Laureate in Medicine Dr. Lou Ignarro, a Nobel Laureate in medicine, is a scientific advisor to HerbaLife Nutrition and receives compensation for his endorsement of HerbaLife Nutrition products. The Nobel Foundation has no affiliation with HerbaLife Nutrition and does not review, approve or endorse HerbaLife Nutrition Products.

30-day money-back guarantee.

Brand IP Statement(s)

Copyright 2021 Herbalife Nutrition

Precautions

Contains soy and sesame. Contains bioengineered food ingredients.

This exclusively formulated product is only available through Herbalife Nutrition Independent distributors.

Formula

CoQ10 Plus is specially formulated with coenzyme Q10 and vitamin D.

Suggested/Recommended/Usage/Directions

Recommended use: Take 1 softgel with a meal, 2 to 3 times per day.

Storage

Store in a cool, dry place with lid tightly closed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CoQ10 Plus by Herbalife Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CoQ10 Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CoQ10 Plus by Herbalife Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
15 mcg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Docosahexaenoic Acid

100 mg per serving Form: Algal Oil

Coenzyme Q-10

Interacts with
198 drugs
100 mg per serving Form: Ubiquinone

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q-10 monograph & interactions

Hawthorn fruit extract

Interacts with
191 drugs
30 mg per serving

Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when...

Hawthorn fruit extract monograph & interactions

Other (inactive) ingredients: Sesame Oil, Gelatin, Water, Glycerin, Glyceryl Monooleate, Peppermint Oil, Silicon Dioxide, Annatto, Soy Lecithin, Titanium Dioxide, Ethyl Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

CoQ10 Plus by Herbalife Nutrition Drug Interactions

Want to check YOUR meds against CoQ10 Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
911Drugs
14 Major 263 Moderate 634 Minor

Ingredients driving the most interactions

Vitamin D 715
Coenzyme Q-10 198
Hawthorn fruit extract 191

Individual Drug Interactions

The ingredients in CoQ10 Plus interact with 911 drugs. Click any drug to see the details.

3 of the 4 ingredients in CoQ10 Plus interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Coenzyme Q-10 Hawthorn fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in CoQ10 Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Coenzyme Q-103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q-10 full monograph & interactions

Hawthorn fruit extract6 drug types · 191 drugs

Nitrates

Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Probable Evidence D
Phosphodiesterase-5 Inhibitors

Theoretically, concomitant use might result in additive vasodilation and hypotension.
Hawthorn might inhibit PDE-5 and cause vasodilation.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that hawthorn can inhibit platelet aggregation. However, its effect in humans is unclear. One observational study shows that patients taking hawthorn shortly before undergoing coronary artery bypass graft (CABG) surgery or valve replacement surgery have a 10% incidence of postoperative bleeding, compared with 1% in those who never consumed hawthorn extract. However, clinical research shows that taking a specific preparation of dried hawthorn leaves and flowers (Crataesor, Soria Natural Lab) 800 mg three times daily for 15 days does not affect platelet aggregation or levels of thromboxane B2, the metabolite of thromboxane A2, in healthy humans.

Likelihood Possible Evidence D
Beta-Blockers

Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Some evidence shows that hawthorn might lower blood pressure and heart rate.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.
Hawthorn appears to improve cardiac output; however, hawthorn does not appear to affect digoxin pharmacokinetics. Case reports suggest that at least one species of hawthorn root extract (Crataegus mexicana) may produce adverse effects similar to digoxin and can cross-react with digoxin assays, leading to falsely elevated plasma digoxin levels.

Likelihood Possible Evidence D
Hawthorn fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CoQ10 Plus, from the product label.

Herbalife Nutrition

See all Herbalife Nutrition products
Name
Herbalife International of America, Inc.
Street Address
800 W. Olympic Blvd., Suite 406
City
Los Angeles
State
CA
ZipCode
90015
Pharmacist Counseling Corner

CoQ10 Plus by Herbalife Nutrition: Common Questions

Does CoQ10 Plus by Herbalife Nutrition interact with any medications?
Yes. Based on its ingredients, CoQ10 Plus has a known interaction with 911 medications, including 14 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CoQ10 Plus contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take CoQ10 Plus if I'm pregnant?
Vitamin D in this product is often used at recommended doses during pregnancy with doctor guidance. However, hawthorn has insufficient safety data — the safety information advises against it in pregnancy. Docosahexaenoic acid and CoQ10 safety data for pregnancy isn't on file. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I take CoQ10 Plus while breastfeeding?
Vitamin D is likely safe during breastfeeding at recommended amounts. CoQ10 safety while breastfeeding has not been well studied, and hawthorn has insufficient safety information — the data advises against it. There's no safety data on file for docosahexaenoic acid while breastfeeding. Check with your doctor before using this product.
What are the side effects of CoQ10 Plus?
Coenzyme Q10 is generally well tolerated; mild gastrointestinal side effects like nausea, diarrhea, or heartburn occur in less than 1% of users and can be reduced by splitting larger doses. Headache or dizziness have been reported rarely. Vitamin D at recommended doses is safe, though very high doses over time can cause toxicity. Hawthorn is generally well tolerated, though serious multiorgan reactions are rare.
Does CoQ10 Plus actually work?
Vitamin D is proven effective for rickets, osteomalacia, familial hypophosphatemia, renal osteodystrophy, and hypoparathyroidism. CoQ10 is likely effective if you have a CoQ10 deficiency and possibly effective for migraine, fibromyalgia, heart failure, and diabetic nerve pain. Hawthorn's effectiveness for heart conditions like angina and arrhythmia is not established in our data. We have no effectiveness data for docosahexaenoic acid.
Is CoQ10 Plus safe to take with my blood pressure medication?
CoQ10 has a Minor-severity interaction with blood pressure drugs in general — it may lower blood pressure slightly on its own. More important: hawthorn in this product has Moderate interactions with beta-blockers and calcium channel blockers. Check your specific medication with your pharmacist or use the tool on this page before you start.
What is hawthorn in this supplement for?
Hawthorn fruit extract has been traditionally used to support cardiovascular and heart function. However, the evidence we hold does not reliably establish its effectiveness for specific heart conditions like angina, arrhythmia, or atherosclerosis. If you have a heart condition, talk to your doctor about whether this supplement fits your needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CoQ10 Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CoQ10 Plus label
Go deeper

The Full Monographs Behind CoQ10 Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Hawthorn

Interacts with 191 drugs

Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when added to standard care. However, the ev...

Read the full Hawthorn monograph →
Sources

Sources & How We Checked

CoQ10 Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 91 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
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Coenzyme Q10 40 references
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Hawthorn 25 references
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See these in context on the Hawthorn monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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