Cranberry Ingredients & Drug Interactions
by VitaScript
What is this page for?
First and foremost: checking Cranberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cranberry is a dietary supplement by VitaScript with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cran-Max. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cranberry by VitaScript
Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry by VitaScript — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cranberry by VitaScript
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
VitaScript Cranberry is a single-ingredient supplement with one active component: Cran-Max, a cranberry extract. The capsule also contains inactive ingredients — sunflower lecithin, cranberry fiber, cranberry seed oil, and guar gum — which are fillers and binders that help deliver the active ingredient.
Does it work?
Moderate evidence
The evidence supports cranberry for urinary tract infections (UTIs), where it is rated possibly effective. For other uses listed on supplement labels — including age-related cognitive decline, benign prostatic hyperplasia (enlarged prostate), cancer prevention, fatty liver disease, and chronic fatigue — the evidence we hold is insufficient to establish whether cranberry works.
Talk with your doctor about whether it fits your specific health goal.
How safe is it?
Well-documented data
Cranberry is generally well tolerated when used as a food or supplement, but concentrated supplement doses haven't been as thoroughly studied as food amounts. The most common side effects are diarrhea and stomach discomfort.
Very large doses — such as 3 to 4 liters of juice daily — can worsen these effects, especially in children. Lower doses, around 16 ounces of juice daily over weeks, have also triggered nausea, vomiting, and diarrhea in some people.
One rare report mentions skin redness and itching. Remember that supplements are not a replacement for medical treatment of infections.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you take warfarin or other blood thinners (Moderate risk), cholesterol medications that are CYP3A4 substrates like atorvastatin (Moderate risk), blood pressure medications like nifedipine (Moderate risk), or pain relievers that are CYP2C9 substrates (Minor risk). Cranberry may raise levels of these drugs in your body.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cranberry may help prevent urinary tract infections, but it's not a treatment once you have one. If you take warfarin, atorvastatin, nifedipine, or similar medications, check with your pharmacist before starting — cranberry can raise drug levels in your blood.
For other uses, evidence is still unclear. Always ask your doctor or pharmacist before switching from food to concentrated supplements.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cranberry, straight from the product label.
| Brand | VitaScript |
|---|---|
| Net contents | 30 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 21, 2024 |
| DSLD ID | 319238 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cranberry by VitaScript, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cran-Max | 500 mg | -- |
Other ingredients: Capsule, Sunflower Lecithin, Cranberry Fiber, Cranberry seed Oil, Guar Gum
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Premium cranberry extract supports urinary tract health Native to North America, the cranberry has a long history of use including supporting urinary tract health and cellular protection. Our Cran-Max Cranberry is produced from pure cranberry fiber, infused with cranberry extract. Through a proprietary process, the natural beneficial constituents of the whole cranberry are intensified and enhanced, making a single capsule more beneficial than 10oz. of cranberry juice. The Ultimate Extract process used in manufacturing combines the marc (insoluble herb material remaining after extraction) with the extract. All beneficial components found in nature are preserved full spectrum to deliver superior bioavailability in our Cran-Max Cranberry supplement.
Ultimate Extract Cran-Max Cranberry extract
Brand IP Statement(s)
Cran-Max and Cran-Max logotypes are used under license with permission of their proprietor.
Storage
Store in a cool, dry place.
Formulation
We guarantee our supplements for potency and purity.
One capsule a day supports urinary tract health
No GMO Ingredients SGS verified the process for manufacturing this product with no GMO ingredients. www.sgs.com/no-gmo Double verified GF Gluten Free
Contains no artificial colors, flavors or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, soy, crustacean shellfish or fish.
Precautions
To report a serious adverse event, call 1-888-710-0006
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
No GMO Ingredients Double verified GF Gluten Free
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Take one capsule daily in between meals.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cranberry by VitaScript label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cranberry by VitaScript
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Cran-Max
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cran-Max monograph & interactionsOther (inactive) ingredients: Capsule, Sunflower Lecithin, Cranberry Fiber, Cranberry seed Oil, Guar Gum. These complete the product’s ingredient list but are not active constituents.
Cranberry by VitaScript Drug Interactions
HelloPharmacist Interaction Report
VitaScript Cranberry contains one active ingredient — Cran-Max — that has documented interactions with medications.
The most serious concern is with blood thinners like warfarin (Coumadin); cranberry may increase how much warfarin stays in your body, raising your bleeding risk. The evidence here is mixed, but case reports do exist.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also interacts moderately with cholesterol medications that are CYP3A4 substrates — a category that includes atorvastatin (Lipitor) and others. One case report describes a patient on atorvastatin who developed muscle breakdown (rhabdomyolysis), severe back pain, and liver problems after drinking 16 ounces of cranberry juice daily for two weeks.
It also theoretically affects blood pressure medications like nifedipine (Procardia) by the same mechanism. Minor interactions are documented with pain relievers that are CYP2C9 substrates (such as diclofenac), though the evidence is conflicting.
Altogether, these interactions span 702 individual medications. We've checked the active ingredient fully.
Please search your exact medications using the tool below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cranberry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cranberry interact with 712 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cranberry interact with drugs. Each result below shows which ingredient is responsible. Cran-Max
ColchicineColchicine, Colcrys, Colsalide Improved, Gloperba, Lodoco, Mitigare
How Colchicine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Colchicine interactionColchicine, ProbenecidColBenemid
How Colchicine, Probenecid interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Colchicine, Probenecid interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Conjugated Estrogens, Methyltestosterone interactionCopanlisibAliqopa
How Copanlisib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Copanlisib interactionCrinecerfontCrenessity
How Crinecerfont interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Crinecerfont interactionCrizotinibXalkori
How Crizotinib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Crizotinib interactionCyclobenzaprineCyclobenzaprine, Cycloprine, Flexeril
How Cyclobenzaprine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Cyclobenzaprine interactionCyclophosphamideCytoxan, Neosar
How Cyclophosphamide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Cyclophosphamide interactionCyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Cyclosporine interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Cyproterone Acetate, Ethinyl Estradiol interactionDabrafenibTafinlar
How Dabrafenib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Dabrafenib interactionDaclatasvir DihydrochlorideDaklinza
How Daclatasvir Dihydrochloride interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Daclatasvir Dihydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDapsoneAczone, Avlosulfon, Dapsone
How Dapsone interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Dapsone interactionDaridorexantQuviviq
How Daridorexant interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Daridorexant interactionDarolutamideNubeqa
How Darolutamide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Darolutamide interactionDarunavirPrezista
How Darunavir interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Darunavir interactionDarunavir, CobicistatPrezcobix
How Darunavir, Cobicistat interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Darunavir, Cobicistat interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDarunavir, RitonavirDarunavir, Ritonavir
How Darunavir, Ritonavir interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Darunavir, Ritonavir interactionDasabuvir Sodium, Ombitasvir, Paritaprevir, RitonavirViekira XR
How Dasabuvir Sodium, Ombitasvir, Paritaprevir, Ritonavir interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Dasabuvir Sodium, Ombitasvir, Paritaprevir, Ritonavir interactionDasatinibPhyrago, Sprycel
How Dasatinib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Dasatinib interactionDeflazacortEmflaza
How Deflazacort interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Deflazacort interactionDelavirdine MesylateRescriptor
How Delavirdine Mesylate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Delavirdine Mesylate interactionDesogestrelCerazette
How Desogestrel interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Desogestrel interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cran-max + Desogestrel, Ethinyl Estradiol interactionDexamethasoneDecadron, Dexone, Dextenza, Dexycu, Hemady, Hexadrol +1 more
How Dexamethasone interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cran-maxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cran-max + Dexamethasone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cranberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cran-Max
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Cranberry, from the product label.
VitaScript
See all VitaScript products- Name
- E-NutritionStore.com
- City
- Elkridge
- State
- MD
- ZipCode
- 21075
- Phone Number
- 443-483-3340
- Web Address
- E-NutritionStore.com
Cranberry by VitaScript: Common Questions
Does Cranberry by VitaScript interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will cranberry cure my urinary tract infection?
What's Cran-Max?
What side effects should I watch for?
Is cranberry safe during pregnancy or breastfeeding?
Can I take this if I take a statin or blood thinner?
Why does the product facts say cranberry interacts with 702 medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cranberry is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cranberry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cranberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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