Cucumber Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cucumber Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cucumber Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for hydration and skin care, cooling and soothing puffy eyes, mild diuretic effect.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cucumber Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cucumber Extract by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Cucumber Extract by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cucumber Extract by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Cucumber Fruit Extract. It's a concentrated form of cucumber, which you eat regularly as a food.
The inactive ingredient is maltodextrin, a common additive used in powdered supplements.
Does it work?
Couldn't assess
The evidence for cucumber extract isn't established in the data we hold. The supplement has been studied for burns, diabetes, high cholesterol (hyperlipidemia), high blood pressure (hypertension), and osteoarthritis, but the reliable evidence to rate it for any of these isn't there yet.
If you're considering it for a specific health goal, ask your pharmacist what the broader research shows outside our data.
How safe is it?
Well-documented data
Cucumber is generally well tolerated as a food and seems to be well tolerated as an extract too. When applied to skin, it's also well tolerated, though allergic eczema and irritation have been reported in rare cases.
Orally, anaphylaxis (a severe allergic reaction) is rare but has been reported. Because concentrated cucumber extracts haven't been studied in pregnancy or while breastfeeding, there isn't enough data to know either way — talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Check any antidiabetes medications (Moderate severity) you take with the search tool on this page before adding this product. No other medication interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cucumber Extract is generally well tolerated, but if you take diabetes medication, it's worth a conversation with your pharmacist first — the ingredient may lower blood sugar further. If you're pregnant or breastfeeding, check with your provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cucumber Extract, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X002KUF6CL |
| Net contents | 500 Gram(s); 17.6 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Apr 24, 2025 |
| DSLD ID | 330675 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cucumber Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cucumber Fruit Extract | 500 mg | -- |
Other ingredients: Maltodextrin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Cucumber Extract Powder 500 mg per serving
Brand IP Statement(s)
BulkSupplements.com Clean & Pure Bulk Supplements
Formulation
Color may vary
Free of: Added sugar, soy, dairy, yeast, gluten
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once or twice daily, or as directed by a physician.
General Statements
Use an accurate milligram scale. New
Storage
Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cucumber Extract by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cucumber Extract by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.
Cucumber Fruit Extract
Interacts with86 drugs
Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydrat...
Cucumber Fruit Extract monograph & interactionsOther (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.
Cucumber Extract by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Cucumber Extract by BulkSupplements.com has one documented interaction: it may work together with antidiabetes drugs (medications that lower blood sugar) and raise the risk of low blood sugar (hypoglycemia).
Animal research suggests cucumber seed extract can decrease blood glucose levels, so if you take diabetes medication, you'll want to monitor your blood sugar closely and talk to your doctor or pharmacist before starting this product.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 85 individual medications.
If you take any antidiabetes medication, use the interaction checker on this page to look up your specific drug before adding this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cucumber Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cucumber Extract interact with 86 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cucumber Extract interact with drugs. Each result below shows which ingredient is responsible. Cucumber Fruit Extract
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Alogliptin, Pioglitazone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
How Glucagon interacts with Cucumber Extract — through 1 ingredient. Tap an ingredient for the detail:
Cucumber Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber Fruit Extract + Glucagon interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cucumber Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cucumber Fruit Extract
Antidiabetes Drugs
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Animal research shows that cucumber seed extract can decrease blood glucose levels. Monitor blood glucose levels closely.
Brand information
Manufacturer and brand details for Cucumber Extract, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Cucumber Extract by BulkSupplements.com: Common Questions
Does Cucumber Extract by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does cucumber extract actually work for anything?
Is it safe if I take diabetes medication?
Can I take it while pregnant or breastfeeding?
What are the side effects?
Is there anything else in this powder besides cucumber?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cucumber Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cucumber Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cucumber Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cucumber 4 references
- Fiume MM, Bergfeld WF, Belsito DV, et al. Safety assessment of Cucumis sativus (cucumber)-derived ingredients as used in cosmetics. Int J Toxicol. 2014;33(2 suppl):47S-64S.
- Vlaicu PC, Rusu LC, Ledesma A, et al. Cucumber anaphylaxis in a latex-sensitized patient. J Investig Allergol Clin Immunol. 2011;21(3):236-9.
- Minaiyan M, Zolfaghari B, Kamal A. Effect of hydroalcoholic and buthanolic extract of Cucumis sativus seeds on blood glucose level of normal and streptozotocin-induced diabetic rats. Iran J Basic Med Sci. 2011;14(5):436-42.
- Zachariae CO. Cucumber contact dermatitis. Contact Dermatitis. 2000;43(4):240-1. DOI
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC