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Dietary supplement

Cucumber Extract Ingredients & Drug Interactions

by BulkSupplements.com

Cucumber Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cucumber Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cucumber Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for hydration and skin care, cooling and soothing puffy eyes, mild diuretic effect.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cucumber extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cucumber Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Cucumber Extract by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cucumber Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: cucumber extract (the whole plant or its seed, depending on the manufacturer's source). Cucumber is a widely eaten vegetable that's been used traditionally for a range of conditions.

The extract concentrate is what you're getting here—not the fresh vegetable you'd eat in a salad. There are no other inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cucumber product and its label doesn't state a use — see Cucumber's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for cucumber extract doesn't establish that it works reliably for any of the conditions listed here—burns, diabetes, high cholesterol (hyperlipidemia), high blood pressure (hypertension), or osteoarthritis. All of these carry a rating of insufficient evidence in our data, which means the research so far hasn't been strong enough to say whether it helps.

The evidence, ingredient by ingredient Cucumber

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cucumber eaten as food is very well tolerated and causes no safety concerns. Cucumber extract and seed extract also appear to be well tolerated orally.

The most common side effects are topical (allergic eczema, redness, irritation if applied to skin). A rare serious effect—anaphylaxis (severe allergic reaction)—has been reported once, in someone who ate a partially peeled cucumber; symptoms included dizziness, vomiting, trouble breathing, and itching.

Safety during pregnancy and breastfeeding hasn't been studied for concentrated extracts, only for cucumber as food. Talk with your doctor or pharmacist about whether to use this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Cucumber

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cucumber.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes medication—insulin, metformin, sulfonylureas, or any other diabetes drug—check with your doctor or pharmacist before starting this product. Cucumber seed extract can lower blood glucose levels, and combining it with your medication may increase the risk of low blood sugar (hypoglycemia).

Close monitoring of your blood glucose will be important if you decide to use this together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cucumber extract is generally well tolerated as a supplement and appears safe in people who aren't allergic to cucumber. The main caution is if you take antidiabetes medication—the extract may lower blood sugar further, so you'll need to monitor closely and check with your doctor first.

There's no reliable evidence it works for any specific health condition listed here. If you're pregnant, breastfeeding, or have a known cucumber allergy, talk with your pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cucumber Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X002IRQNHD
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 253788
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cucumber Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
1000
UPC/BARCODE
X002IRQNHD
IngredientAmount% DV
Cucumber extract500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

Formulation

Color may vary

Free of: Added sugar, soy, dairy, yeast, gluten, additives

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once or twice daily, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cucumber Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cucumber Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cucumber Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.

Cucumber extract

Interacts with
86 drugs
500 mg per serving

Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydrat...

Cucumber extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cucumber Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Cucumber Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cucumber extract 86

Individual Drug Interactions

The ingredients in Cucumber Extract interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cucumber Extract interact with drugs. Each result below shows which ingredient is responsible. Cucumber extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cucumber Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cucumber extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Animal research shows that cucumber seed extract can decrease blood glucose levels. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cucumber extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cucumber Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Cucumber Extract by BulkSupplements.com: Common Questions

Does Cucumber Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Cucumber Extract has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cucumber Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does cucumber extract actually help with diabetes?
The evidence isn't strong enough to say. Animal research shows cucumber seed extract can lower blood glucose, which is promising, but we don't have reliable human studies proving it works for diabetes itself. That's why it's rated as insufficient evidence in our data.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough data on concentrated cucumber extracts in pregnancy or breastfeeding to know either way. Eating fresh cucumber is fine, but this supplement hasn't been studied. Talk with your doctor or pharmacist for personalized advice based on your situation.
What are the side effects of cucumber extract?
Most people tolerate it well when taken by mouth. Topically (on skin), the most common reactions are allergic eczema, redness, and irritation. A very rare serious reaction—anaphylaxis with breathing trouble—has been reported once in someone with a severe cucumber allergy.
Does this product contain any fillers or other inactive ingredients?
No. This is just cucumber extract with no other inactive ingredients listed.
Will this lower my blood pressure or cholesterol?
We don't have reliable evidence it does either. Both high blood pressure and high cholesterol are listed here with insufficient evidence ratings, meaning the research isn't established enough to say it helps.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cucumber Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cucumber Extract label
Go deeper

The Full Monographs Behind Cucumber Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cucumber

Interacts with 86 drugs

Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydration and soothing the skin, but solid hum...

Read the full Cucumber monograph →
Sources

Sources & How We Checked

Cucumber Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cucumber 4 references
  1. Fiume MM, Bergfeld WF, Belsito DV, et al. Safety assessment of Cucumis sativus (cucumber)-derived ingredients as used in cosmetics. Int J Toxicol. 2014;33(2 suppl):47S-64S.
  2. Vlaicu PC, Rusu LC, Ledesma A, et al. Cucumber anaphylaxis in a latex-sensitized patient. J Investig Allergol Clin Immunol. 2011;21(3):236-9.
  3. Minaiyan M, Zolfaghari B, Kamal A. Effect of hydroalcoholic and buthanolic extract of Cucumis sativus seeds on blood glucose level of normal and streptozotocin-induced diabetic rats. Iran J Basic Med Sci. 2011;14(5):436-42.
  4. Zachariae CO. Cucumber contact dermatitis. Contact Dermatitis. 2000;43(4):240-1. DOI

See these in context on the Cucumber monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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