Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

DAA Test-5 Ingredients & Drug Interactions

by Advanced Nutrition Systems

DAA Test-5 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DAA Test-5 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DAA Test-5 is a dietary supplement by Advanced Nutrition Systems with 2 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 692 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium D-Aspartic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DAA Test-5 by Advanced Nutrition Systems

Ask about any prescription or over-the-counter medication and we check it for interactions with DAA Test-5 by Advanced Nutrition Systems — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DAA Test-5 by Advanced Nutrition Systems

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “DAA Test 5 Complex” is a proprietary blend — the label gives one combined amount (3,296 mg) without saying how much of each component you get.
  • “Testosterone Support Complex” is a proprietary blend — the label gives one combined amount (176 mg) without saying how much of each component you get.

DAA Test-5 contains five active ingredients: diindolylmethane (a compound from cruciferous vegetables), chrysin (a plant flavonoid), sodium D-aspartic acid (an amino acid salt), fenugreek extract, and eurycoma longifolia extract (also called tongkat ali). The product also includes inactive ingredients — microcrystalline cellulose, gelatin, magnesium stearate, titanium dioxide, and silicon dioxide — which serve as binders, fillers, and capsule material.

Diindolylmethane and chrysin are studied for hormone-related effects. Sodium D-aspartic acid is the salt form of an amino acid.

Fenugreek and eurycoma longifolia are herbal extracts traditionally used for sexual function and metabolic support. The exact amounts of each active ingredient and the strength of the herbal extracts are not listed here.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: boost testosterone levels and support strength, energy, muscle mass, recovery, and libido.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Erectile dysfunction (ED), Male infertility, Muscle strength, Sexual arousal — and 4 related terms.
  • The strongest evidence on file: Fenugreek is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Fenugreek is rated "Possibly Effective" for Sexual arousal.
  • Also on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire.

The evidence for what this product does is sparse. Diindolylmethane has insufficient evidence for prostate, breast, colorectal, and cervical health.

Chrysin shows insufficient evidence for anxiety, athletic performance, cancer, HIV, muscle strength, and gout. Fenugreek has possibly effective evidence for sexual function, arousal, period pain, and blood sugar control in type 2 diabetes — these are the strongest claims in the product.

Eurycoma longifolia is possibly effective for sexual desire but possibly ineffective for athletic performance; evidence for bone health and back pain is insufficient. For the sodium D-aspartic acid component specifically, it is likely effective for cystic fibrosis and possibly effective for a specific type of kidney damage from amphotericin B, but these are not typical reasons someone would take this testosterone-support product.

The blend ingredients (DAA Test 5 Complex and Testosterone Support Complex) have no effectiveness data on file.

The evidence, ingredient by ingredient Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated short-term but long-term safety is not established. Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting.

A rare serious side effect (drug rash with eosinophilia and systemic symptoms) has been reported; one unconfirmed case of stroke occurred in a patient using diindolylmethane among several other supplements, though the contribution was unclear. Pregnancy and lactation data rate it as likely safe — however, the product also contains ingredients with different pregnancy ratings (see below).

Chrysins and fenugreek show different safety profiles across pregnancy and lactation. Chrysin lacks adequate safety data for both pregnancy and breastfeeding, so both should be avoided.

Fenugreek is likely unsafe in pregnancy (particularly near delivery, when it may cause unusual body odor in newborns) but possibly safe while breastfeeding. Eurycoma longifolia has insufficient data for both — avoid during pregnancy, and breastfeeding safety is unclear.

Sodium is well tolerated at normal dietary levels but excessive intake is tied to high blood pressure and kidney issues. Fenugreek commonly causes bloating, diarrhea, nausea, and abdominal pain; severe allergic reactions are rare.

Eurycoma longifolia is generally tolerated short-term, but if it raises testosterone beyond normal range, acne and liver stress are possible.

Side effects, ingredient by ingredient Sodium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Fenugreek, Chrysin, Diindolylmethane, Eurycoma Longifolia, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 692 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use estrogens or hormonal contraceptives (diindolylmethane and chrysin may reduce their effects), blood thinners or antiplatelet drugs like warfarin or clopidogrel (chrysin and fenugreek add bleeding risk), blood pressure medications including metoprolol (sodium and fenugreek lower blood pressure), lithium (sodium alters lithium levels and toxicity risk), corticosteroids (sodium can cause dangerous sodium overload), antidiabetes drugs (fenugreek can lower blood sugar), theophylline or phenytoin (fenugreek may reduce their levels), or seizure drugs including mephenytoin (chrysin may interfere). Eurycoma longifolia may also reduce propranolol effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is marketed for testosterone support and sexual function, with the strongest evidence behind its fenugreek and eurycoma longifolia content. It's not right for anyone on hormonal contraceptives, hormone replacement therapy, blood thinners, blood pressure medications, lithium, or certain seizure and diabetes drugs without checking first.

Pregnancy and breastfeeding are not advised given the mixed safety data across ingredients. If you take any prescription medications, talk with your doctor or pharmacist before adding this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DAA Test-5, straight from the product label.

Brand Advanced Nutrition Systems
Net contents 96 Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 180473
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DAA Test-5 by Advanced Nutrition Systems, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
24
IngredientAmount% DV
Diindolylmethane0 NP--
Chrysin0 NP--
Sodium D-Aspartic Acid3120 mg--
DAA Test 5 Complex3296 mg--
Testosterone Support Complex176 mg--
Fenugreek (Trigonella foenum-graecum) extract0 NP--
Eurycoma longifolia extract0 NP--

Other ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Titanium Dioxide, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Natural Testosterone Booster

DAA Test-5 is designed to boost testosterone levels by activating signaling pathways in the body. This releases natural testosterone to support increased strength, energy, muscle mass, recovery and libido

Testosterone Booster

Strength Libido Mass

Please recycle.

Made in the USA Proudly made in the USA with carefully selected ingredients of international and domestic origin.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 1 serving (4 capsules) once a day. Recommended dosing regimen includes taking one serving for twelve straight days, followed by two days off before repeating. Please read the entire label before use. Should not be consumed for more than 4 consecutive weeks with a 2 to 4 week washout period between cycles.

Precautions

Please read the entire label before use. Should not be consumed for more than 4 consecutive weeks with a 2 to 4 week washout period between cycles.

This product was produced in a facility that may also process ingredients containing milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans.

Warning: Do not use if pregnant, nursing, or plan on becoming pregnant.

This product is intended for use by healthy adults over the age of 18. Do not use this product continuously for more than 8 weeks. Do not combine with alcohol. Not intended for use by those with a medical condition. Use only as directed. Do not exceed recommended daily intake.

Consult a physician or licensed qualified health care professional prior to use if you are pregnant or nursing, or if you are taking medication, including, but not limited to MAO inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, or other stimulants, or if you have a medical condition, including, but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma.

Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headache or shortness of breath. Do not use if safety seal under cap is broken.

Keep out of reach of children.

Brand IP Statement(s)

KSM-66 is a registered trademark of Ixoreal Biomed Private Limited.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DAA Test-5 by Advanced Nutrition Systems label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DAA Test-5 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DAA Test-5 by Advanced Nutrition Systems

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container24 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

DAA Test 5 Complex

3296 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Titanium Dioxide, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

DAA Test-5 by Advanced Nutrition Systems Drug Interactions

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692Drugs
485 Moderate 207 Minor

Ingredients driving the most interactions

Sodium D-Aspartic Acid 205

Individual Drug Interactions

The ingredients in DAA Test-5 interact with 692 drugs. Click any drug to see the details.

1 of the 2 ingredients in DAA Test-5 interact with drugs. Each result below shows which ingredient is responsible. Sodium D-Aspartic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in DAA Test-5 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium D-Aspartic Acid7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium D-Aspartic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DAA Test-5, from the product label.

Advanced Nutrition Systems

See all Advanced Nutrition Systems products
Name
Advanced Nutrition Systems
Pharmacist Counseling Corner

DAA Test-5 by Advanced Nutrition Systems: Common Questions

Does DAA Test-5 by Advanced Nutrition Systems interact with any medications?
Yes. Based on its ingredients, DAA Test-5 has a known interaction with 692 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DAA Test-5 contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Not without talking to your doctor first. Diindolylmethane is rated likely safe, but fenugreek is likely unsafe in pregnancy, and chrysin and eurycoma longifolia lack enough safety data for pregnancy. Fenugreek is possibly safe while breastfeeding, but the others aren't well studied. Your doctor or pharmacist can weigh the individual ingredients against your situation.
What is fenugreek in this product for?
Fenugreek extract is included for sexual function and arousal — it has possibly effective evidence for both — and for blood sugar control in diabetes. It's also traditionally used to support milk supply in breastfeeding, though evidence is limited.
What does eurycoma longifolia do?
Eurycoma longifolia (tongkat ali) is in the product for sexual desire, where it has possibly effective evidence. It may also support testosterone levels. Long-term safety and product quality vary widely, so choose carefully.
Can I take this with my blood pressure medication?
Not without checking with your doctor. Both sodium D-aspartic acid and fenugreek in this product can lower blood pressure, and their combined effect with your medication could be risky. Talk to your doctor or pharmacist first.
Will this help with testosterone levels?
Eurycoma longifolia in the product has possibly effective evidence for sexual desire and may increase testosterone in aging males. However, the fenugreek and other ingredients are not proven to raise testosterone. The product's name suggests testosterone support, but the evidence is limited to these ingredients.
What are the most common side effects?
Fenugreek often causes bloating, diarrhea, nausea, and stomach pain. Diindolylmethane may cause headache, nausea, diarrhea, gas, or rash. These are generally mild, but if you develop severe symptoms, stop and contact your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DAA Test-5 label
Go deeper

The Full Monographs Behind DAA Test-5’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

DAA Test-5's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Chrysin 23 references
  1. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
  2. Lee H, Yeom H, Kim YG, et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem Pharmacol 1998;55:1369-75. PubMed
  3. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  4. Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999;58:431-8. PubMed
  5. Kao YC, Zhou C, Sherman M, et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect 1998;106:85-92. PubMed
  6. Jeong HJ, Shin YG, Kim IH, Pezzuto JM. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 1999;22:309-12. PubMed
  7. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  8. Walle T, Otake Y, Brubaker JA, et al. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol 2001;51:143-6. DOI
  9. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed
  10. Lautraite S, Musonda AC, Doehmer J, et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002;17:45-53. PubMed
  11. Han, D. H., Denison, M. S., Tachibana, H., and Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem 2002;66(7):1479-1487. PubMed
  12. O'Leary, K. A., de Pascual-Tereasa, S., Needs, P. W., Bao, Y. P., O'Brien, N. M., and Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat.Res 7-13-2004;551(1-2):245-254. PubMed
  13. Woodman, O. L. and Chan, E. C. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786-790. PubMed
  14. Simons, A. L., Renouf, M., Hendrich, S., and Murphy, P. A. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric.Food Chem 5-18-2005;53(10):4258-4263. PubMed
  15. Kim, H. J., Lee, S. B., Park, S. K., Kim, H. M., Park, Y. I., and Dong, M. S. Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. Arch Pharm Res 2005;28(10):1114-1121 PubMed
  16. Moon, Y. J., Wang, X., and Morris, M. E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 2006;20(2):187-210. PubMed
  17. Landolfi, R., Mower, R. L., and Steiner, M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem Pharmacol 5-1-1984;33(9):1525-1530. PubMed
  18. Tsyrlov, I. B., Mikhailenko, V. M., and Gelboin, H. V. Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids. Biochim.Biophys Acta 4-13-1994;1205(2):325-335. PubMed
  19. Collins, B. M., McLachlan, J. A., and Arnold, S. F. The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. Steroids 1997;62(4):365-372. PubMed
  20. Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139(10):4252-4263. PubMed
  21. Liu G, Xie W, He AD, et al. Antiplatelet activity of chrysin via inhibiting platelet aIIbß3-mediated signaling pathway. Mol Nutr Food Res 2016;60(9):1984-93.
  22. Noh K, Oh do G, Nepal MR, et al. Pharmacokinetic interaction of chrysin with caffeine in rats. Biomol Ther (Seoul) 2016;24(4):446-52. PubMed
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Fenugreek 30 references
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Eurycoma Longifolia 4 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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