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Dietary supplement

Dexaprine XR Ingredients & Drug Interactions

by iFORCE Nutrition

Dexaprine XR label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dexaprine XR against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Dexaprine XR is a dietary supplement by iFORCE Nutrition with 3 active ingredients.Based on those ingredients, 1,514 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Dexaprine XR by iFORCE Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Dexaprine XR by iFORCE Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Dexaprine XR by iFORCE Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Dexaprine Tri-Phase Ignition System” is listed as a grouped ingredient — the label gives one combined amount (645 mg) without saying how much of each component you get.
  • “Thermogenic Delivery System” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Extended Release Energy Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

Dexaprine XR contains 6 active ingredients. The main ones are caffeine anhydrous (a stimulant for alertness and energy), Citrus aurantium or bitter orange (containing compounds that affect heart rate and blood pressure), Green Tea extract (a source of caffeine and plant compounds), and Rauwolfia serpentina or Indian snakeroot (a potent herbal ingredient with cardiovascular and nervous-system effects).

Acacia rigidula extract is also included; some products in this category have been found to contain unapproved synthetic stimulants. The product also lists proprietary blends called the Dexaprine Tri-Phase Ignition System, Thermogenic Delivery System, Extended Release Energy Complex, and Alpha-2 Adrenergic Activation Complex — their individual component ingredients are listed separately above.

The inactive ingredients are rice flour and magnesium stearate.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: mental focus appetite control energy.
  • We looked for evidence on: Mental alertness, Fatigue, Cognitive function, Athletic performance, Concentration, Wakefulness.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Green Tea is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Chronic fatigue syndrome (CFS), Cognitive function, Mental alertness.

The evidence for Dexaprine XR's active ingredients is mixed. Caffeine is effective for neonatal apnea (a breathing problem in newborns) and postoperative headache, and likely effective for mental alertness and athletic performance; it's possibly effective for bronchopulmonary dysplasia (a lung condition in premature infants).

Green Tea extract is likely effective for human papillomavirus (HPV) and possibly effective for ovarian cancer and high cholesterol. For the other ingredients—Citrus aurantium, Acacia rigidula, and Rauwolfia serpentina—we hold insufficient reliable evidence to rate their effectiveness for the uses this product is likely marketed for, such as athletic performance, weight loss, or alertness.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate amounts is generally well tolerated by healthy adults, but high doses can cause anxiety, insomnia, tremors, nausea, restlessness, and diarrhea. Anaphylaxis (a severe allergic reaction) is rare but possible in sensitive individuals.

In pregnancy, caffeine carries possibly safe and possibly unsafe ratings—the data are mixed, so talk with your doctor about safe limits. Small amounts pass into breast milk and are usually considered acceptable in moderate intake, though they can affect the baby.

Green Tea extract is generally well tolerated as a beverage but concentrated high-dose extracts have rarely caused liver injury; it's possibly safe in pregnancy and lactation at moderate amounts. Citrus aurantium can raise blood pressure and heart rate, especially with caffeine, and is possibly unsafe in pregnancy and not recommended while breastfeeding.

Acacia rigidula may contain an unapproved synthetic stimulant and lacks human safety data; it's unsafe in pregnancy and should be avoided while breastfeeding. Rauwolfia serpentina contains potent alkaloids and should only be used under medical supervision; it's unsafe in pregnancy and should be avoided while breastfeeding because reserpine passes into milk.

Several case reports link these stimulant combinations to heart rhythm problems and cardiac events.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Indian Snakeroot, Green Tea, Bitter Orange, Caffeine, Acacia Rigidula.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,515 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Dexaprine XR, check with your doctor or pharmacist if you take any monoamine oxidase inhibitors (MAOIs) for depression, barbiturates or seizure medications, blood-pressure medications (especially beta-blockers or antihypertensives), blood thinners or antiplatelet drugs, heart medications like digoxin or dipyridamole, antipsychotics, levodopa for Parkinson's disease, diabetes medications, quinolone antibiotics, acid reflux medication cimetidine, dextromethorphan (cough suppressant), midazolam (sedative), or cholesterol medications like atorvastatin. These are the medication types with documented Major or Moderate severity interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Dexaprine XR is a multi-ingredient stimulant product designed to boost energy and alertness, and it contains some ingredients with documented effectiveness for those purposes. However, it carries significant risks with many common medications—especially blood-pressure drugs, heart medications, seizure drugs, and certain antidepressants—and the serious adverse effects reported (heart attack, stroke, cardiac arrest) warrant caution.

If you take any prescription medication, use the checker on this page to screen your exact drugs, then talk with your doctor or pharmacist before you start. Pregnant or breastfeeding individuals should not use this product without explicit medical approval.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dexaprine XR, straight from the product label.

Brand iFORCE Nutrition
Net contents 60 Caplet(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 169360
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dexaprine XR by iFORCE Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
Servings per container
60
IngredientAmount% DV
Caffeine Anhydrous0 NP--
Dexaprine Tri-Phase Ignition System645 mg--
Thermogenic Delivery System0 NP--
Acacia rigidula extract0 NP--
Citrus aurantium0 NP--
Extended Release Energy Complex0 NP--
Green Tea extract0 NP--
Alpha-2 Adrenergic Activation Complex0 NP--
Rauwolfia serpentina0 NP--
Isopropyloctopamine0 NP--

Other ingredients: Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Mental focus Appetite control Energy Xtreme series

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 caplet on an empty stomach before breakfast. For those who wish to experience extreme results, a second caplet may be consumed 4-8 hours later. Do not exceed 2 caplets in an 24 hour period.

Precautions

Do not exceed 2 caplets in an 24 hour period. Warning: Do not exceed recommended dose. Contains caffeine.

Do not consume synephrine or caffeine from other sources, including but not limited to coffee, tea, soda, and other dietary supplements or medications containing phenylephrine or caffeine.

Do not use for more than 8 weeks.

Consult with your physician prior to use if you are taking medications, including but not limited to MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudophedrine, or other stimulants.

Consult your physician prior to use if you have a medical condition, including but not limited to heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache, or shortness of breath.

Keep Out Of Reach Of Children.

Formula

Contains caffeine.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dexaprine XR by iFORCE Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dexaprine XR label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dexaprine XR by iFORCE Nutrition

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dexaprine Tri-Phase Ignition System

645 mg per serving
  • › Thermogenic Delivery System
  • › Extended Release Energy Complex
  • › Alpha-2 Adrenergic Activation Complex

Other (inactive) ingredients: Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dexaprine XR by iFORCE Nutrition Drug Interactions

Want to check YOUR meds against Dexaprine XR?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,514Drugs
104 Major 1,408 Moderate 2 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Dexaprine XR interact with 1,514 drugs. Click any drug to see the details.

0 of the 3 ingredients in Dexaprine XR interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Dexaprine XR with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Dexaprine XR, from the product label.

iFORCE Nutrition

Name
iFORCE Nutrition
Web Address
www.iforcenutrition.com
Pharmacist Counseling Corner

Dexaprine XR by iFORCE Nutrition: Common Questions

Does Dexaprine XR by iFORCE Nutrition interact with any medications?
Yes. Based on its ingredients, Dexaprine XR has a known interaction with 1,514 medications, including 104 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dexaprine XR contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is caffeine in this product effective for boosting alertness and athletic performance?
Yes—caffeine is documented as likely effective for both mental alertness and athletic performance. The research supports its use for these purposes, though individual responses vary.
Can I take this product while pregnant?
The safety data for these ingredients in pregnancy are mixed or limited. Caffeine is rated possibly safe and possibly unsafe, and the other ingredients—especially Citrus aurantium, Acacia rigidula, and Rauwolfia serpentina—carry warnings against use in pregnancy or lack sufficient safety information. Talk with your doctor before use.
What are the most common side effects of caffeine in this product?
Common side effects include anxiety, insomnia, tremors, restlessness, nausea, diarrhea, and headache. These are more likely at higher doses. Serious effects like stroke are rare.
Why does the label mention a 'stimulant' in Acacia rigidula?
Some Acacia rigidula products have been found to contain an unapproved synthetic stimulant called BMPEA. This ingredient lacks human safety data, and we cannot verify whether this product contains it—check the label or contact the manufacturer directly.
Is this safe to take with my blood-pressure medication?
Not necessarily. Citrus aurantium and Rauwolfia serpentina in this product can both affect blood pressure, and Rauwolfia carries major-severity risks with beta-blockers. Use the medication checker on this page with your exact medication, then confirm with your doctor or pharmacist before starting.
Can I breastfeed while taking this product?
Caffeine and other ingredients pass into breast milk. While small amounts of caffeine are usually considered acceptable, the other ingredients—especially Acacia rigidula and Rauwolfia serpentina—are not recommended while breastfeeding due to lack of safety data. Talk with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Dexaprine XR is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dexaprine XR label
Sources

Sources & How We Checked

Dexaprine XR's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 549 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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