Escape Restraint Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Escape Restraint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Escape Restraint is a dietary supplement by Health Concerns with 5 active ingredients. Its ingredients are commonly taken for liver and digestive complaints, fever and inflammation, anxiety, restlessness, and trouble sleeping.Based on those ingredients, 955 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Atractylodes, Cyperus, Gardenia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Escape Restraint by Health Concerns
Ask about any prescription or over-the-counter medication and we check it for interactions with Escape Restraint by Health Concerns — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Escape Restraint by Health Concerns
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Escape Restraint contains five active ingredients in a proprietary blend: ligusticum, gardenia, cyperus, barley shen qu, and red atractylodes. The blend also includes inactive ingredients—vegetable gum, silicon dioxide, stearic acid, and cellulose—which are fillers and binders that help hold the tablet together.
Does it work?
Strong evidence
The evidence for Escape Restraint's ingredients is mixed and incomplete. Barley shen qu is likely effective for high cholesterol and heart disease prevention.
Gardenia, cyperus, and red atractylodes all lack sufficient reliable evidence to rate their effectiveness for the conditions they're traditionally used for—including anxiety, depression, and digestive issues. Ligusticum has not been rated in our data.
How safe is it?
Well-documented data
Barley shen qu is generally well tolerated when taken orally; the most common side effects are bloating, flatulence, and an unpleasant taste. Some people may have allergic reactions.
Gardenia, cyperus, and red atractylodes have limited human safety data and should be used cautiously. Gardenia may rarely cause allergic contact dermatitis or, with very long-term use, skin discoloration.
All three ingredients are advised against during pregnancy and breastfeeding due to insufficient safety information.
Meds to double-check
Moderate interaction found
Before taking Escape Restraint, check with your doctor or pharmacist if you take any CNS depressants (like benzodiazepines, barbiturates, or other sedating drugs), blood thinners or antiplatelet medications, aromatase inhibitors (breast cancer drugs), stimulant laxatives, triclabendazole (an antiparasitic), or any medications metabolized through the liver. Cyperus and atractylodes carry the most serious documented interactions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Escape Restraint is best approached with caution because its main active ingredients have limited human safety data and carry interactions with sedating drugs, blood thinners, and other medications. Barley shen qu has solid evidence for cholesterol and heart health, but the blend's other ingredients lack proven effectiveness in reliable trials.
If you take any medications—especially blood thinners, benzodiazepines, barbiturates, or cancer drugs—talk with your doctor or pharmacist before starting this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Escape Restraint, straight from the product label.
| Brand | Health Concerns |
|---|---|
| Net contents | 90 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2017 |
| DSLD ID | 72949 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Escape Restraint by Health Concerns, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 750 mg | -- |
| Ligusticum | 0 NP | -- |
| Gardenia | 0 NP | -- |
| Cyperus | 0 NP | -- |
| Barley Shen Qu | 0 NP | -- |
| Red Atractylodes | 0 NP | -- |
Other ingredients: Vegetable Gum, Silicon Dioxide, Stearic Acid, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Two to three tablets 3 times per day between meals.
Precautions
Notice: This product is not intended for use by pregnant women.
General Statements
Made in the U.S.A.
Brand IP Statement(s)
Chinese traditional formulas
Combining modern research and ancient wisdom
Formula
Yue Ju Wan
Pinyin/Latin: Cang Zhu, Xiang Fu, Shen Qu, Chuan Xiong, Zhi Zi.
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Escape Restraint by Health Concerns label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Escape Restraint by Health Concerns
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Ligusticum
- › Gardenia
- › Cyperus
- › Barley Shen Qu
- › Red Atractylodes
Other (inactive) ingredients: Vegetable Gum, Silicon Dioxide, Stearic Acid, Cellulose. These complete the product’s ingredient list but are not active constituents.
Escape Restraint by Health Concerns Drug Interactions
HelloPharmacist Interaction Report
Escape Restraint by Health Concerns contains several ingredients with documented interactions with medications.
The most serious concern involves cyperus (also called adrue), which has Moderate-severity interactions with CNS depressants—a large class that includes benzodiazepines, barbiturates, and other sedating drugs. Cyperus may increase drowsiness and impair motor reflexes when combined with these medications.
Read the full breakdown — every affected drug type, severity by severity
Gardenia interacts Moderately with stimulant laxatives and may increase their effects and side effects. Red atractylodes carries Moderate interactions with blood thinners (anticoagulant and antiplatelet drugs), aromatase inhibitors (used in some cancer treatments), and a barbiturate called hexobarbital; it also has Minor interactions with certain drug-metabolizing enzymes that can affect how your body processes many other medications.
Barley Shen Qu has a Moderate interaction with triclabendazole, an antiparasitic medication.
We could not check ligusticum—no data is on file for it. Altogether, these interactions span 956 individual medications.
Before you start Escape Restraint, run any prescription or over-the-counter medications you take through the interaction checker on this page, and talk with your doctor or pharmacist about whether this product is right for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Escape Restraint?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Escape Restraint interact with 955 drugs. Click any drug to see the details.
4 of the 5 ingredients in Escape Restraint interact with drugs. Each result below shows which ingredient is responsible. Red Atractylodes Cyperus Gardenia Barley Shen Qu
AbciximabReoPro
How Abciximab interacts with Escape Restraint — through 1 ingredient. Tap an ingredient for the detail:
Red AtractylodesAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Red Atractylodes + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Escape Restraint — through 1 ingredient. Tap an ingredient for the detail:
Red AtractylodesAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Red Atractylodes + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Escape Restraint — through 1 ingredient. Tap an ingredient for the detail:
Red AtractylodesAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Red Atractylodes + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Escape Restraint — through 1 ingredient. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Escape Restraint — through 1 ingredient. Tap an ingredient for the detail:
Red AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Escape Restraint — through 1 ingredient. Tap an ingredient for the detail:
Red AtractylodesAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Red Atractylodes + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusBarbiturates Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental increases total sleep time three-fold compared to the effects of sodium thiopental alone.
Read the full Cyperus + Acetaminophen, Butalbital interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusBarbiturates Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental increases total sleep time three-fold compared to the effects of sodium thiopental alone.
Read the full Cyperus + Acetaminophen, Butalbital, Caffeine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusBarbiturates, Cns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental increases total sleep time three-fold compared to the effects of sodium thiopental alone.
Read the full Cyperus + Acetaminophen, Butalbital, Caffeine, Codeine interactionRed AtractylodesCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Red Atractylodes + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Butalbital, Codeine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Butalbital, Codeine Phosphate interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Caffeine, Codeine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Caffeine, Codeine, Salicylamide interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Caffeine, Dihydrocodeine interactionRed AtractylodesCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Red Atractylodes + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Chlorzoxazone, Codeine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Codeine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Codeine, Doxylamine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Codeine, Methocarbamol interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Dichloralantipyrine, Isometheptene interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Dichloralphenazone, Isometheptene interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Dichlorophenazone, Isometheptane interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Diphenhydramine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Hydrocodone interactionRed AtractylodesCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Red Atractylodes + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Escape Restraint — through 1 ingredient. Tap an ingredient for the detail:
Red AtractylodesAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Red Atractylodes + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Meperidine interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Escape Restraint — through 2 ingredients. Tap an ingredient for the detail:
CyperusCns Depressants Moderate
Interaction Summary
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Cyperus + Acetaminophen, Oxycodone interactionRed AtractylodesCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Red Atractylodes + Acetaminophen, Oxycodone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Escape Restraint with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Red Atractylodes
Anticoagulant/Antiplatelet Drugs
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Laboratory research suggests that atractylenolides II and III, constituents of atractylodes, reduce platelet activation. So far, this has not been shown in humans.
Aromatase Inhibitors
Theoretically, atractylodes may have an additive effect when used with other aromatase inhibitors.
Laboratory research suggests that atractylodes and its constituents exhibit aromatase inhibitor effects.
Hexobarbital
Theoretically, taking atractylodes may prolong the therapeutic and adverse effects of hexobarbital.
In animals, atractylodes has been shown to prolong the effects of hexobarbital. These effects have not been shown in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
In animals, atractylodes administered at high doses has been shown to induce CYP1A2 activity. This effect has not been shown in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
In animals, atractylodes administered at high doses has been shown to inhibit CYP3A1 activity, which is a homolog to the human CYP3A4 enzyme. This effect has not been shown in humans.
Cyperus
Barbiturates
Animal research suggests that taking adrue in combination with sodium thiopental increases total sleep time three-fold compared to the effects of sodium thiopental alone. Theoretically, concomitant use of adrue and barbiturates might increase the risk of drowsiness and motor reflex depression. Some barbiturates include amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), and others.
Benzodiazepines
Animal research suggests that taking adrue in combination with diazepam increases total sleep time four-fold compared to the effects of diazepam alone. Theoretically, concomitant use adrue and benzodiazepines might increase the risk of drowsiness and motor reflex depression. Some benzodiazepines include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.
Cns Depressants
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone. Theoretically, concomitant use of adrue with CNS depressants might cause additive sedation. Some CNS depressants include benzodiazepines, such as diazepam (Valium), alprazolam (Xanax), triazolam (Halcion), and estazolam (ProSom); barbiturates, such as mephobarbital (Mebaral), phenobarbital (Luminal Sodium), and pentobarbital sodium (Nembutal); zolpidem (Ambien); and others.
Gardenia
Stimulant Laxatives
Theoretically, gardenia might increase the effects and adverse effects of stimulant laxatives.
Animal research shows that geniposide, a glucoside found in gardenia fruit, may function as a laxative and cause diarrhea when taken orally.
Barley Shen Qu
Triclabendazole (Egaten)
Theoretically, barley might decrease the clinical effects of triclabendazole.
Animal research suggests that a diet supplemented with barley can reduce the bioavailability of triclabendazole when taken concomitantly. This effect has not been shown in humans.
Brand information
Manufacturer and brand details for Escape Restraint, from the product label.
Health Concerns
See all Health Concerns products- Name
- Health Concerns
- Street Address
- 8001 Capwell Drive
- City
- Oakland
- State
- CA
- ZipCode
- 94621
- Phone Number
- (800) 233-9355
- Web Address
- www.healthconcerns.com/pro
Escape Restraint by Health Concerns: Common Questions
Does Escape Restraint by Health Concerns interact with any medications?
How can one product interact with so many drugs?
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What is cyperus and why does it interact with sedating drugs?
Does this product have fillers or other inactive ingredients?
Is barley safe if I have celiac disease or gluten sensitivity?
What does barley shen qu do?
What's the most common side effect of barley in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Escape Restraint’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gardenia
Interacts with 21 drugsGardenia fruit has a long history in traditional Chinese medicine and is also used as a natural food coloring. While early lab and animal studies are interesting, strong human evidence for i...
Read the full Gardenia monograph → Herb & supplement monographAdrue
Interacts with 256 drugsAdrue (Cyperus articulatus) is a sedge whose rhizome has long been used in traditional medicine for nausea and other stomach complaints, and as a mild calming agent. Solid human studies are...
Read the full Adrue monograph → Herb & supplement monographBarley
Interacts with 1 drugBarley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad') cholesterol when eaten regularly. It...
Read the full Barley monograph → Herb & supplement monographAtractylodes
Interacts with 801 drugsAtractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue, often as part of multi-herb formulas. Modern resea...
Read the full Atractylodes monograph →Sources & How We Checked
Escape Restraint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Gardenia 5 references
- Kubo, Y., Nonaka, S., and Yoshida, H. Allergic contact dermatitis from gardenia fruit. Contact Dermatitis 1990;22(2):65-7. PubMed
- Yamauchi, K., Fujimoto, N., Kuwano, S., Inouye, H., and Inoue, K. The mechanism of purgative action of geniposide, an iridoid glucoside of the fruit of Gardenia, in mice. Planta Med 1976;30(1):39-47.
- Paulsen, E., Skov, P. S., and Andersen, K. E. Immediate skin and mucosal symptoms from pot plants and vegetables in gardeners and greenhouse workers. Contact Dermatitis 1998;39(4):166-170. PubMed
- Mizawa M, Andoh T, Shimizu T. Gardenia fruit-related blue-gray skin pigmentation. JAMA Dermatol. 2020. PubMed
- Tong T, Fu J, Kong Y. Recurrent Abdominal Pain in a 61-Year-Old Woman. Gastroenterology 2023;164(6):887-890. PubMed
Adrue 1 reference
- Rakotonirina, V. S., Bum, E. N., Rakotonirina, A., and Bopelet, M. Sedative properties of the decoction of the rhizome of Cyperus articulatus. Fitoterapia 2001;72(1):22-29. PubMed
Barley 15 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Fernandez-Anaya S, Crespo JF, Rodriguez JR, et al. Beer anaphylaxis. J Allergy Clin Immunol 1999;103:959-60.
- Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003;349:1360-8. . PubMed
- Ferre, I., Giraldez, F. J., Alvarez-Bujidos, M. L., and Mantecon, A. R. Influence of barley supplement on plasma concentration of triclabendazole metabolites in sheep. Vet.Rec. 11-22-1997;141(21):549-551. PubMed
- Curioni, A., Santucci, B., Cristaudo, A., Canistraci, C., Pietravalle, M., Simonato, B., and Giannattasio, M. Urticaria from beer: an immediate hypersensitivity reaction due to a 10- kDa protein derived from barley. Clin Exp Allergy 1999;29(3):407-413. PubMed
- Fernandez-Anaya, S., Crespo, J. F., Rodriguez, J. R., Daroca, P., Carmona, E., Herraez, L., and Lopez-Rubio, A. Beer anaphylaxis. J Allergy Clin Immunol. 1999;103(5 Pt 1):959-960.
- Cronin, E. Contact dermatitis from barley dust. Contact Dermatitis 1979;5(3):196. PubMed
- Block, G., Tse, K. S., Kijek, K., Chan, H., and Chan-Yeung, M. Baker's asthma. Studies of the cross-antigenicity between different cereal grains. Clin Allergy 1984;14(2):177-185.
- van Ketel, W. G. Immediate type allergy to malt in beer. Contact Dermatitis 1980;6(4):297-298. PubMed
- Ellis, H. J., Doyle, A. P., Day, P., Wieser, H., and Ciclitira, P. J. Demonstration of the presence of coeliac-activating gliadin-like epitopes in malted barley. Int Arch Allergy Immunol. 1994;104(3):308-310. PubMed
- Vidal, C. and Gonzalez-Quintela, A. Food-induced and occupational asthma due to barley flour. Ann Allergy Asthma Immunol. 1995;75(2):121-124.
- Gutgesell, C. and Fuchs, T. Contact urticaria from beer. Contact Dermatitis 1995;33(6):436-437. PubMed
- Baker, P. G. and Read, A. E. Oats and barley toxicity in coeliac patients. Postgrad.Med J 1976;52(607):264-268. PubMed
- Nakase, M., Usui, Y., Alvarez-Nakase, A. M., Adachi, T., Urisu, A., Nakamura, R., Aoki, N., Kitajima, K., and Matsuda, T. Cereal allergens: rice-seed allergens with structural similarity to wheat and barley allergens. Allergy 1998;53(46 Suppl):55-57. PubMed
- Pereira, F., Rafael, M., and Lacerda, M. H. Contact dermatitis from barley. Contact Dermatitis 1998;39(5):261-262. PubMed
Atractylodes 6 references
- Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed
- Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. PubMed
- Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. PubMed
- Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. PubMed
- Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. PubMed
- Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC