Major interaction on record — check this product against your medications before combining. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

Essential Amino Complete Tangy Orange Ingredients & Drug Interactions

by GNC Pro Performance

Essential Amino Complete Tangy Orange label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Essential Amino Complete Tangy Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Essential Amino Complete Tangy Orange is a dietary supplement by GNC Pro Performance with 9 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 273 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin B6, Sodium Chloride, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Essential Amino Complete Tangy Orange by GNC Pro Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with Essential Amino Complete Tangy Orange by GNC Pro Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Essential Amino Complete Tangy Orange by GNC Pro Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 7 of its 16 active ingredients.
  • “Branched-Chain Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.
  • “Essential Amino Acid Blend” is a proprietary blend — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.
  • “Electrolyte Complex” is a proprietary blend — the label gives one combined amount (1.11 Gram(s)) without saying how much of each component you get.

This powder contains 16 ingredients, with 11 that are active components: amino acids (essential amino acids including histidine, threonine, lysine, phenylalanine, and methionine, plus branched-chain amino acids leucine, isoleucine, and valine), vitamin B6, and the minerals potassium and sodium. The remaining five ingredients are inactive—citric acid, malic acid, natural and artificial flavors, sucralose, acesulfame potassium, and food colorings (FD&C Red #40 and FD&C Yellow #6)—that provide texture, taste, and appearance.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: lean muscle maintenance and recovery support.
  • We looked for evidence on: Athletic performance, Muscle strength, muscle protein synthesis, exercise recovery.
  • The closest evidence on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for this product depends on which amino acids and micronutrients are the target. Vitamin B6 is effective for treating sideroblastic anemia and vitamin B6 deficiency, and is likely effective for high homocysteine levels; it is possibly effective for pregnancy-related nausea.

Lysine is possibly effective for cold sores. Histidine is possibly effective for cholera but has insufficient evidence for eczema, kidney failure, and rheumatoid arthritis.

Threonine, phenylalanine, and methionine lack established evidence for their stated roles in this formulation—the data we hold rates threonine as possibly ineffective for ALS and phenylalanine as possibly ineffective for ADHD. Potassium and sodium have no established effectiveness ratings in our data.

The evidence, ingredient by ingredient Vitamin B6 Potassium Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at doses under 100 mg daily; common side effects include abdominal pain, headache, nausea, and vomiting. High doses over time can cause nerve damage (sensory neuropathy), particularly at daily intakes exceeding 1,000 mg.

Potassium and sodium are generally well tolerated in normal food amounts, but too much can cause serious electrolyte problems—high potassium can lead to irregular heartbeat and heart block, while high sodium can worsen blood pressure and heart strain. Most amino acids in this product are generally well tolerated; lysine may cause stomach upset and diarrhea, phenylalanine may cause anxiety, insomnia, constipation, or headache, and threonine may cause headache or mild digestive upset.

We hold no pregnancy or breastfeeding safety data for threonine and lysine; vitamin B6 is rated likely safe in pregnancy, phenylalanine is unsafe in pregnancy and lactation, and potassium and sodium are likely safe in both.

Side effects, ingredient by ingredient Vitamin B6 Potassium Sodium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Lysine, Phenylalanine, Potassium, Vitamin B6, Threonine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 273 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, tell your doctor or pharmacist if you take NMDA antagonists (psychiatric or neurological drugs that block NMDA receptors)—threonine may reduce their effect. Also check if you take levodopa for Parkinson's disease, older antidepressants called MAOIs, blood pressure medications (especially ACE inhibitors or ARBs), seizure medications (phenobarbital or phenytoin), the heart drug amiodarone, steroid medications, the mood stabilizer lithium, or the muscle relaxant baclofen.

For any of these, your healthcare provider needs to know before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is an amino acid supplement with added micronutrients. It may be considered by people looking to support muscle or protein intake, though the effectiveness ratings vary by ingredient.

If you take blood pressure medications, seizure medications, mood stabilizers like lithium, older psychiatric drugs (MAOIs), Parkinson's disease medication (levodopa), or psychiatric medications that block NMDA receptors, talk with your doctor or pharmacist before starting this product—the interactions are real. Anyone with kidney disease should check with their healthcare provider first, since potassium buildup can be dangerous in that setting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Essential Amino Complete Tangy Orange, straight from the product label.

Brand GNC Pro Performance
Barcode (UPC) 048107189242
Net contents 15.87 Ounce(s); 450 Gram(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 259615
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Essential Amino Complete Tangy Orange by GNC Pro Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 Gram(s)
Maximum serving Sizes:
15 Gram(s)
Servings per container
30
UPC/BARCODE
048107189242
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Vitamin B60.64 mg38%
L-Leucine2.5 Gram(s)--
Potassium Chloride0 NP--
L-Isoleucine1.25 Gram(s)--
L-Valine1.25 Gram(s)--
Sodium Chloride0 NP--
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Potassium210 mg4%
Branched-Chain Amino Acids5 Gram(s)--
Trisodium Citrate Dihydrate0 NP--
Essential Amino Acid Blend5 Gram(s)--
Histidine, Micronized0 NP--
Electrolyte Complex1.11 Gram(s)--
Chloride760 mg33%
Sodium215 mg9%
Total Essential Amino Acids10 Gram(s)--
Threonine, Micronized0 NP--
Lysine, Micronized0 NP--
Phenylalanine, Micronized0 NP--
Tryptophan, Micronized0 NP--
Methionine, Micronized0 NP--

Other ingredients: Citric Acid, Natural and Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium, FD&C Red #40, FD&C Yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Results Essential amino acids (EAA), including branched chain amino acids (BCAA), cannot be made by the body and therefore must be obtained through your diet. These amino acids are crucial to lean muscle maintenance and for helping to reduce muscle protein breakdown. Essential Amino Complete contains 5 grams of BCAA in an optimal 2:1:1 ratio to support protein synthesis, plus an additional 5 grams of EAA for muscle recovery and electrolytes for hydration.

10G Total Aminos 5G BCAA 5G EAA 0G Sugar

Tangy Orange Natural and artificial flavors

Formulation

Quality Essential Amino Complete is tested and certified Banned Substance Free. It tastes amazing, contains no sugar and mixes easily with a simple stir, shake or blend.

Usage Benefits During Workout Hydrates and fuels muscles. Post-Workout Supports recovery. Non-Training Days May be used to support muscle protein synthesis and help reduce muscle protein breakdown. When used in conjunction with an exercise program.

Fuels muscles Supports recovery Replenishes electrolytes

Informed-choice.org Trusted by sport Products bearing this logo have been tested for banned substances by LGC Science, Inc., a world-class anti-doping lab. Product was tested for over 220 banned substances on the 2020 World Anti-Doping Agency (WADA) Prohibited List via LGC skip lot testing protocol #ICP0307.

Banned substance free

Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, mix one scoop in 10-16 fl. oz. of cold water and consume during workouts, post-workout and/or throughout the day. See usage benefits.

General Statements

Notice: Significant product settling may occur.

Seals/Symbols

Informed-choice.org Trusted by sport

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Essential Amino Complete Tangy Orange by GNC Pro Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Essential Amino Complete Tangy Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Essential Amino Complete Tangy Orange by GNC Pro Performance

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size15 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
0.64 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Potassium

Interacts with
62 drugs
210 mg per serving Form: Potassium Chloride

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Electrolyte Complex

1.11 Gram(s) per serving

Chloride

760 mg per serving Form: Potassium Chloride, Sodium Chloride

Sodium

Interacts with
205 drugs
215 mg per serving Form: Sodium Chloride, Trisodium Citrate Dihydrate

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Total Essential Amino Acids

10 Gram(s) per serving
  • › Branched-Chain Amino Acids
  • › Essential Amino Acid Blend

Other (inactive) ingredients: Citric Acid, Natural and Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium, FD&C Red #40, FD&C Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Essential Amino Complete Tangy Orange by GNC Pro Performance Drug Interactions

Want to check YOUR meds against Essential Amino Complete Tangy Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
273Drugs
8 Major 264 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin B6 210
Sodium Chloride 205
Potassium 62

Individual Drug Interactions

The ingredients in Essential Amino Complete Tangy Orange interact with 273 drugs. Click any drug to see the details.

3 of the 9 ingredients in Essential Amino Complete Tangy Orange interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium Chloride Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Essential Amino Complete Tangy Orange with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium Chloride7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Chloride full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Essential Amino Complete Tangy Orange, from the product label.

GNC Pro Performance

See all GNC Pro Performance products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Essential Amino Complete Tangy Orange by GNC Pro Performance: Common Questions

Does Essential Amino Complete Tangy Orange by GNC Pro Performance interact with any medications?
Yes. Based on its ingredients, Essential Amino Complete Tangy Orange has a known interaction with 273 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Essential Amino Complete Tangy Orange contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I have kidney disease?
Check with your doctor first. This product contains potassium and sodium—both can build up to dangerous levels in the blood if your kidneys aren't working well. Your doctor or pharmacist can tell you if it's okay for your situation.
Can I take this while pregnant?
It depends on the ingredient. Vitamin B6 is likely safe, potassium and sodium are likely safe, but phenylalanine is unsafe during pregnancy, and we don't have enough data on threonine and lysine. Talk with your doctor or pharmacist before taking it while pregnant.
Will this help me build muscle?
This product contains essential amino acids, which your body needs for muscle and protein synthesis. However, the data we hold doesn't specify an effectiveness rating for muscle growth—amino acids alone are not a substitute for resistance training and overall nutrition.
What are the most common side effects?
Most people tolerate the amino acids well. Vitamin B6 may cause abdominal pain, headache, or nausea at normal doses. Some amino acids like phenylalanine can cause anxiety, insomnia, or constipation, and lysine may cause diarrhea or stomach upset.
Does it have any fillers or artificial ingredients?
The active ingredients are amino acids and vitamins. The inactive ingredients include citric acid, malic acid, natural and artificial flavors, sucralose, acesulfame potassium, and two artificial food dyes (FD&C Red #40 and FD&C Yellow #6)—so yes, it contains artificial sweeteners and colorings.
Is it safe to take with my blood pressure medication?
That depends on which medication you take. This product contains sodium and potassium, which can interfere with several blood pressure drugs—especially ACE inhibitors and ARBs. Check with your doctor or pharmacist before starting it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Essential Amino Complete Tangy Orange is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Essential Amino Complete Tangy Orange label
Go deeper

The Full Monographs Behind Essential Amino Complete Tangy Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Essential Amino Complete Tangy Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 131 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
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  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
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Potassium 12 references
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Sodium 38 references
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Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

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Threonine 4 references
  1. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
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  4. Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed

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Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
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  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
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  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

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Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
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  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

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Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
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  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
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  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
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  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

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