Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

GABA Ingredients & Drug Interactions

by NutraKey

GABA label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GABA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GABA is a dietary supplement by NutraKey with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma-Aminobutyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GABA by NutraKey

Ask about any prescription or over-the-counter medication and we check it for interactions with GABA by NutraKey — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GABA by NutraKey

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gamma-aminobutyric acid (GABA), a neurotransmitter — a chemical messenger in your brain and nervous system. It comes as a powder with no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: restful sleep and recovery with relaxation.
  • We looked for evidence on: Anxiety, Insomnia, Post-traumatic stress disorder (PTSD), Psychological well-being, stress, sleep quality — and 2 related terms.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Post-traumatic stress disorder (PTSD), Psychological well-being.

The evidence for GABA isn't established yet. Studies haven't gathered enough reliable data to rate it for anxiety, ADHD, athletic performance, chronic bronchitis, or cerebral palsy.

If you're thinking about it for one of these reasons, talk with your doctor or pharmacist about whether the current research supports it for your situation.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

GABA is generally well tolerated in the short term, but long-term safety hasn't been well studied, so we don't have solid data on what happens if you take it for months or years. The most common side effects from oral GABA in studies were drowsiness, nausea, stomach upset, minor throat burning, and muscle weakness.

There isn't enough safety information during pregnancy, and the safety data advises against using it while breastfeeding.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any blood pressure medications (the main concern) and any drugs that make you drowsy — sedatives, sleep aids, pain relievers, or psychiatric medications. The blood pressure risk is moderate; the drowsiness risk is minor but worth asking about.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

NutraKey GABA might appeal to someone looking for a natural nervous-system support, but the evidence for its benefits isn't solid yet. If you take blood pressure medication or anything sedating, check with your pharmacist first.

Pregnant or nursing? Talk to your doctor — the safety data doesn't support it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GABA, straight from the product label.

Brand NutraKey
Barcode (UPC) 820103456418
Net contents 125 Gram(s); 0.27 lb(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 287401
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GABA by NutraKey, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
42
UPC/BARCODE
820103456418
IngredientAmount% DV
Gamma-Aminobutyric Acid3000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

GABA is a potent neurotransmitter necessary for restful sleep and recovery GABA (Gamma-Aminobutryic Acid) is an amino acid that regulates brain & nerve cell activity by inhibiting the number of neurons firing in the brain. GABA is referred to as "the brain's natural calming agent." By inhibiting over-stimulation of the brain, GABA may help to promote relaxation and ease nervous tension. Taken at bedtime, supplemental GABA may assist some people in the initiation of sleep and produce a deeper and more beneficial sleep cycle. GABA Stimulates the Production of Growth Hormone (GH) In studies, Growth Hormone (GH) has been found to facilitate the metabolism of fats in the body. GH is also known for its powerful muscle building effects. Increasing GH can have a range of positive results, especially for bodybuilders. GH decreases naturally with age, so the older you get, the harder it is to lose fat. That's one of the reasons supplementing with GABA has become so popular. Studies show GABA has the potential to increase GH Fivefold One study conducted by First Medical Clinic at the University of Milan in Italy, found that 90 minutes after GABA supplementation, GH levels increased 5 times. This research studied 19 subjects who took 5 grams of GABA orally compared to 18 placebo subjects. After 90 minutes, GH levels in the GABA group were found to have increased by 500%.

Formulation

GH is one of the most powerful hormones in your body In the human body, GH promotes the growth of lean muscle tissue and the loss of fat. As you age, growth hormone levels drop which is one of the reasons you lose muscle and gain fat as you age. In a controlled trial, Arginine and other amino acids were combined with weight training to effectively enhance growth hormone levels. High-Performance Liquid Chromatography (HPLC) Verified

Recovery Essentials Ultra Pure

No Fillers

Ultra Micronized Max Bioavailability Speed Muscle Recovery Promote Relaxation & Sleep Stimulate GH Production Regulate Neurotransmitter Pharmaceutical Grade

GABA powder is hygroscopic and may clump during storage, this does not affect the quality of the product. GABA easily dissolves in liquids and does not have an unpleasant taste.

Increase natural GH levels leading to less body fat Promote restful sleep and recovery Improve lean tissue to stored fat ratio Reduce the GH lowering effects of aging Benefit from the effects of naturally elevated growth hormone

Seals/Symbols

Made in the USA

FDA Statement of Identity

Dietary Supplement

General Statements

Nutrakeyhealth.com Follow Us Free Giveaways Facebook Pintrest Instagram Twitter #MakeLifeBetter

Pure Nutrition Go Green

Suggested/Recommended/Usage/Directions

Recommended Use: Take 1 serving (1 scoop) with water or your favorite beverage. For best results, take before sleep on an empty stomach.

GABA easily dissolves in liquids and does not have an unpleasant taste. GABA may also be dissolved directly in the mouth for quicker absorption.

Precautions

Warning: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.

Do not use if seal is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

NutraKey Health Performance Inc

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GABA by NutraKey label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GABA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GABA by NutraKey

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container42 Amounts shown are per serving.

Gamma-Aminobutyric Acid

Interacts with
419 drugs
3000 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma-Aminobutyric Acid monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

GABA by NutraKey Drug Interactions

Want to check YOUR meds against GABA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

Gamma-Aminobutyric Acid 419

Individual Drug Interactions

The ingredients in GABA interact with 419 drugs. Click any drug to see the details.

1 of the 1 ingredient in GABA interact with drugs. Each result below shows which ingredient is responsible. Gamma-Aminobutyric Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in GABA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma-Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma-Aminobutyric Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GABA, from the product label.

NutraKey

See all NutraKey products
Name
Nutrakey
Street Address
975 Bennett Drive
City
Longwood
State
FL
ZipCode
32750
Web Address
Nutrakeyhealth.com
Pharmacist Counseling Corner

GABA by NutraKey: Common Questions

Does GABA by NutraKey interact with any medications?
Yes. Based on its ingredients, GABA has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GABA contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take GABA if I'm pregnant?
There isn't enough safety information to know whether GABA is safe in pregnancy. Talk with your doctor or pharmacist for personalized advice before starting it.
Can I take GABA while breastfeeding?
The safety data advises against GABA while breastfeeding. If you're considering it, discuss it with your doctor first.
What are the most common side effects?
Drowsiness, nausea, stomach upset, minor throat burning, and muscle weakness show up in studies. Keep in mind long-term safety hasn't been well studied.
Does GABA actually work for anxiety or sleep?
The evidence isn't strong enough yet to say. Studies haven't gathered enough reliable data to rate GABA for anxiety, ADHD, or other conditions. Ask your pharmacist whether the current research fits your situation.
Is this GABA powder the same as the GABA my brain makes naturally?
Yes, it's the same chemical — gamma-aminobutyric acid — but taking it as a supplement is different from what your body produces naturally. We don't fully understand how much of the supplement actually reaches your brain or how it behaves once it does.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GABA label
Go deeper

The Full Monographs Behind GABA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

GABA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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