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Dietary supplement

Gentian Ingredients & Drug Interactions

by Herb Pharm

Gentian label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gentian against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gentian is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian rhizome with root (Gentiana lutea) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gentian by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Gentian by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gentian by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This is a straightforward single-ingredient product: gentian rhizome and root extract from Gentiana lutea. Gentian has a long history in herbal medicine, traditionally used to support digestion and appetite.

The liquid form is made with certified organic cane alcohol and distilled water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gentian's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: gastrointestinal system restoration and digestive support.
  • We looked for evidence on: Diarrhea, Flatulence, Gastritis, Gastroesophageal reflux disease (GERD), indigestion, loss of appetite — and 2 related terms.
  • The closest evidence on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Gastroesophageal reflux disease (GERD), Flatulence, Gastritis.

The evidence we hold doesn't establish that gentian works for wound healing, weight loss, sinus inflammation, or stomach irritation—all show insufficient reliable evidence to rate. That doesn't mean it doesn't help; it means the research just isn't there yet in the data we have.

The evidence, ingredient by ingredient Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gentian is generally well tolerated in small amounts by healthy adults, but it can upset your stomach and hasn't been well studied at high doses. Some trial participants taking gentian in combination with turmeric and ginger reported nausea, vomiting, diarrhea, and bloating, though it's unclear how much gentian alone was responsible.

The safety data advises against use during pregnancy and while breastfeeding, so if either applies to you, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Gentian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gentian.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check all blood pressure medications (antihypertensives) before taking gentian—the combination could lower your pressure too much. If you're on any other prescription drugs, use the interaction checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gentian is a single-herb liquid extract with a traditional digestive role, but we don't yet have solid evidence it works for any specific condition. The main concern is with blood pressure medications—gentian may lower pressure further.

If you take antihypertensives or have any other prescription drugs, run them through the checker on this page, and confirm with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gentian, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700001568
Net contents 4 fl. Oz.; 120 mL
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 183576
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gentian by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
168
UPC/BARCODE
090700001568
IngredientAmount% DV
Gentian rhizome with root (Gentiana lutea) extract657 mg--

Other ingredients: certified organic Cane Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake Well Before Using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 or 3 times per day. Best taken 15 to 20 minutes before meals.

Precautions

Keep Out of the Reach if Children

Storage

Store away from heat & light

General

010

Formula

Gentiana lutea

Gentian Liquid Extract

General Statements

System restoration Gastrointestinal

Dry herb / menstruum ratio: 1:4

Seals/Symbols

USDA Organic

FDA Statement of Identity

Herbal Supplement

Formulation

Gluten-Free

We prepare our Gentian Extract from the rhizome with root of certified organically grown Gentiana lutea plants. Certified organic by Organic Certifiers

FDA Disclaimer Statement

This statement has not bee evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gentian by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gentian label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gentian by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container168 Amounts shown are per serving.

Gentian rhizome with root (Gentiana lutea) extract

Interacts with
172 drugs
657 mg per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian rhizome with root (Gentiana lutea) extract monograph & interactions

Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gentian by Herb Pharm Drug Interactions

Want to check YOUR meds against Gentian?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Gentian rhizome with root (Gentiana lutea) extract 172

Individual Drug Interactions

The ingredients in Gentian interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gentian interact with drugs. Each result below shows which ingredient is responsible. Gentian rhizome with root (Gentiana lutea) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gentian with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian rhizome with root (Gentiana lutea) extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian rhizome with root (Gentiana lutea) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gentian, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Gentian by Herb Pharm: Common Questions

Does Gentian by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Gentian has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gentian contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Gentian if I'm pregnant or breastfeeding?
The safety data advises against it during both pregnancy and breastfeeding because there isn't enough reliable information. Talk with your doctor or pharmacist for personalized guidance.
Will this upset my stomach?
Gentian can upset the stomach, especially at higher doses. In one trial combining it with turmeric and ginger, several people had nausea, vomiting, diarrhea, or bloating—though it's not clear how much was gentian alone.
What is gentian supposed to do?
Gentian has a long traditional use in herbal medicine for digestion and appetite, but the evidence we hold doesn't yet establish it works for wound healing, weight loss, sinus inflammation, or stomach irritation.
Is this safe to take long-term at high doses?
Gentian isn't well studied at high doses, so we don't have good safety data for that. Stick with the dose on the label, and check with your doctor or pharmacist if you're thinking of using it differently.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gentian label
Go deeper

The Full Monographs Behind Gentian’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

Gentian's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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