Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Gentian Complex Ingredients & Drug Interactions

by True Botanica

Gentian Complex label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gentian Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gentian Complex is a dietary supplement by True Botanica with 2 active ingredients. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian Herb Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gentian Complex by True Botanica

Ask about any prescription or over-the-counter medication and we check it for interactions with Gentian Complex by True Botanica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gentian Complex by True Botanica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Gentian Herb Extract” is listed as a grouped ingredient — the label gives one combined amount (0.20 mL) without saying how much of each component you get.
  • “Gentian” is listed as a grouped ingredient — the label gives one combined amount (0.80 mL) without saying how much of each component you get.

Gentian Complex contains one active ingredient: gentian (Gentiana lutea). Gentian is a bitter root traditionally used to support digestion and appetite.

The product also contains several inactive ingredients — glycerin, apple cider vinegar, salts, trace minerals, potassium sorbate, and citric acid — that help preserve and flavor the liquid.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gentian's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive support and appetite stimulation.
  • We looked for evidence on: Diarrhea, Flatulence, Gastritis, Gastroesophageal reflux disease (GERD), indigestion, bloating — and 2 related terms.
  • The closest evidence on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Gastroesophageal reflux disease (GERD), Flatulence, Gastritis.

The evidence we hold for gentian doesn't establish reliable effectiveness for wound healing, obesity, rhinosinusitis (sinus inflammation), or gastritis (stomach inflammation). On all these uses, the data is insufficient to rate how well it works.

This doesn't mean gentian doesn't help — just that we don't yet have solid evidence for these particular purposes.

The evidence, ingredient by ingredient Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gentian is generally well tolerated in small amounts by healthy adults, but it can upset your stomach and isn't well studied at higher doses. In one trial, people taking gentian in combination with turmeric and ginger reported nausea, vomiting, diarrhea, and bloating; some had to stop because of these side effects.

The safety data advises against use during pregnancy and while breastfeeding. There isn't enough reliable information to know whether it's safe for you or your baby in those situations — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Gentian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gentian.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications (antihypertensives) with the search tool below before taking this product. Taking gentian alongside them may lower your blood pressure too much.

No other drug interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gentian Complex may interest you if you're exploring traditional digestive bitters, but the evidence for specific benefits isn't established in our data. If you take blood pressure medication, check your exact drugs with the tool on this page before you start.

Stomach upset is possible. Talk with your pharmacist if you're pregnant, breastfeeding, or taking any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gentian Complex, straight from the product label.

Brand True Botanica
Net contents 55 mL; 1.86 Fluid Ounce(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336223
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gentian Complex by True Botanica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
55
IngredientAmount% DV
Water, Distilled0 NP--
Gentiana lutea0 NP--
Gentian Herb Extract0.2 mL--
Gentiana lutea28 mg--
Gentian0.8 mL--

Other ingredients: Glycerin, Apple Cider Vinegar, Salts, Trace Minerals, Potassium Sorbate, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before using.

Suggested use: 20 drops (1 ml, 1/5 tsp) one to three times daily, or as suggested by your health care provider.

Formulation

Made with alcohol free, rhythmical proprietary processes. Contains no milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, sesame, soy, wheat, or gluten.

Made with alcohol free, rhythmical proprietary processes.

Herbal Tincture

Precautions

Consult your health care provider before using this product if you are pregnant, lactating or have medical concerns or compatibility issues.

FDA Statement of Identity

A Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gentian Complex by True Botanica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gentian Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gentian Complex by True Botanica

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container55 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gentian Herb Extract

Interacts with
172 drugs
0.2 mL per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian Herb Extract monograph & interactions

Gentian

Interacts with
172 drugs
0.8 mL per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian monograph & interactions

Other (inactive) ingredients: Glycerin, Apple Cider Vinegar, Salts, Trace Minerals, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gentian Complex by True Botanica Drug Interactions

Want to check YOUR meds against Gentian Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Gentian Herb Extract 172

Individual Drug Interactions

The ingredients in Gentian Complex interact with 172 drugs. Click any drug to see the details.

1 of the 2 ingredients in Gentian Complex interact with drugs. Each result below shows which ingredient is responsible. Gentian Herb Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gentian Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian Herb Extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian Herb Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gentian Complex, from the product label.

True Botanica

See all True Botanica products
Name
True Botanica
Pharmacist Counseling Corner

Gentian Complex by True Botanica: Common Questions

Does Gentian Complex by True Botanica interact with any medications?
Yes. Based on its ingredients, Gentian Complex has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gentian Complex contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough reliable information to know whether gentian is safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist — they can discuss your situation and help you decide what's right for you.
What's gentian supposed to do?
Gentian is a bitter root traditionally used to support digestion and appetite. We don't yet have solid evidence that it works reliably for wound healing, weight management, sinus inflammation, or stomach inflammation in our current data.
Will this upset my stomach?
It might. Gentian can irritate the stomach in some people. In one trial, several participants had nausea, vomiting, diarrhea, or bloating while taking a combination product that included gentian and other herbs.
Is gentian the only active ingredient here?
Yes — gentian is the one active ingredient. The rest are inactive ingredients like glycerin, apple cider vinegar, and salts that preserve and flavor the liquid.
What are the inactive ingredients for?
They're fillers and preservatives. Glycerin and apple cider vinegar help preserve the product and add flavor, while the salts, trace minerals, potassium sorbate, and citric acid keep it stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gentian Complex label
Go deeper

The Full Monographs Behind Gentian Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

Gentian Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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