Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

HemodrauliX Ingredients & Drug Interactions

by Axis Labs

HemodrauliX label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HemodrauliX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

HemodrauliX is a dietary supplement by Axis Labs with 5 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 1,107 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape Seed Extract, L-Arginine Alpha-Ketoglutarate, L-Citrulline Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against HemodrauliX by Axis Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with HemodrauliX by Axis Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of HemodrauliX by Axis Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

HemodrauliX contains five active ingredients. Three are forms of L-arginine—L-arginine alpha-ketoglutarate, L-arginine hydrochloride, and L-arginine malate—amino acids that your body uses to produce nitric oxide, which relaxes blood vessels.

One is L-citrulline malate, another amino acid that your body converts into L-arginine. The fifth is grape seed extract, a plant-derived compound.

The product also contains several inactive ingredients: bovine gelatin (capsule material), silicon dioxide, magnesium stearate, and titanium dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: athletic performance and blood flow support.
  • We looked for evidence on: Athletic performance, Erectile dysfunction (ED), Hypertension, Muscle soreness, Cardiovascular disease (CVD), Chronic venous insufficiency (CVI) — and 3 related terms.
  • The strongest evidence on file: Grape is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.
  • Also on file: Grape is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Cardiovascular disease (CVD), Erectile Dysfunction (ED), Hypertension, and more.

The data we hold does not establish an effectiveness rating for L-arginine or L-citrulline malate for any condition in this product. However, grape seed extract shows possibly effective evidence for chronic venous insufficiency (CVI)—a condition where poor blood flow in leg veins causes swelling and discomfort.

Grape seed extract was possibly ineffective for chemotherapy-induced nausea, hay fever, and obesity in the studies we reviewed. L-citrulline shows possibly effective evidence for athletic performance, but possibly ineffective evidence for sarcopenia (age-related muscle loss).

For cardiovascular disease, heart failure, Reye syndrome, and diabetes, the evidence for L-citrulline is insufficient to rate.

The evidence, ingredient by ingredient L-arginine Grape L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine is generally well tolerated in the short term, but the data advises caution—it can lower blood pressure and may not be safe for everyone, and safety for self-treatment is not well established. Common side effects from oral L-arginine include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

Grape seed extract appears generally well tolerated; most common effects are abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea. L-citrulline malate is generally well tolerated in healthy adults, though long-term safety is not fully studied; gastrointestinal discomfort and heartburn are the main reported effects.

For pregnancy, L-arginine alpha-ketoglutarate and L-arginine malate are rated possibly safe, but L-citrulline safety data advises against use during pregnancy due to lack of reliable information. For breastfeeding, safety data for L-citrulline advises against supplemental use; lactation safety for the L-arginine forms is not on file.

Grape seed extract is likely safe in pregnancy and lactation.

Side effects, ingredient by ingredient L-arginine Grape L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Grape, L-arginine, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,108 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking HemodrauliX, check with your doctor or pharmacist if you take any blood pressure medications (antihypertensives, ACE inhibitors, or ARBs), as the risk of dangerously low blood pressure is moderate. Also flag blood thinners or antiplatelet drugs (warfarin, aspirin), potassium-sparing diuretics, diabetes medications, sildenafil (Viagra), and isoproterenol.

If you take cyclosporine, cyclosporine absorption can drop by up to 30% with grape extracts. The ingredient L-citrulline also theoretically interacts with PDE-5 inhibitors (phosphodiesterase-5 inhibitors like sildenafil).

Grape seed extract may also affect how your liver processes many other medications through several enzyme pathways, so mention all your drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for blood flow support, primarily through its L-arginine and L-citrulline content. It may appeal to people interested in athletic performance or circulation, but it's not for everyone—especially if you take blood pressure medications, blood thinners, diabetes drugs, or any medication that affects potassium.

The extensive interaction profile and the fact that safety for self-treatment is not well established mean you should talk with your doctor or pharmacist before starting it, and absolutely before combining it with any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HemodrauliX, straight from the product label.

Brand Axis Labs
Barcode (UPC) 665752697122
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306543
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HemodrauliX by Axis Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
20
UPC/BARCODE
665752697122
IngredientAmount% DV
L-Arginine Alpha-Ketoglutarate1000 mg--
L-Arginine Hydrochloride1000 mg--
Grape Seed Extract315 mg--
L-Citrulline Malate1000 mg--
L-Arginine Malate1000 mg--

Other ingredients: Bovine Gelatin, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take six (6) capsules with eight (8) ounces of water thirty (30) minutes prior to exercise. For best results, do not take more than once a day or more than (5) times a week. Take 6x capsules + 8 oz water 30 minutes before exercise

Storage

Keep in a cool, dry place.

Keep in a cool, dry place.

Precautions

Warning: keep out of reach of children. This product is not intended for anyone under the age of 18, pregnant, or nursing.

This product is not intended for anyone under the age of 18, pregnant, or nursing. Do not take this product if you have any medical condition and/or are taking any prescription medication(s).

Consult your physician before using this or any dietary supplement. Do not use if you have, or are at risk of a myocardial infraction (heart attack), diabetes, asthma, high blood pressure, high cholesterol, arthritis, heart disease, stroke, or suffering from any inflammatory diseases. Discontinue use if experiencing any adverse side effects.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Anabolic hyper-vasodilation system

Pump capsules Supplies 20 workouts Deep muscle fiber stimulation Upregulates N.O. production Skin-bursting pumps

General Statements

"The world's strongest N.O. supplement!"

Get VIP Access Exclusive offers Exciting giveaways Newest products

Visit www.axislabs.com for more on our entire line of nutritional supplements.

FDA Statement of Identity

Dietary Supplement

Dietary Supplement

Seals/Symbols

Made in the USA Manufactured at a GMP Good Manufacturing Practice Compliant Facility Purity & Potency Guaranteed

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HemodrauliX by Axis Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HemodrauliX label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HemodrauliX by Axis Labs

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Arginine Alpha-Ketoglutarate

Interacts with
403 drugs
1000 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Alpha-Ketoglutarate monograph & interactions

L-Arginine Hydrochloride

Interacts with
403 drugs
1000 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Hydrochloride monograph & interactions

Grape Seed Extract

Interacts with
910 drugs
315 mg per serving Form: Polyphenols

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Grape Seed Extract monograph & interactions

L-Citrulline Malate

Interacts with
178 drugs
1000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline Malate monograph & interactions

L-Arginine Malate

Interacts with
403 drugs
1000 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Malate monograph & interactions

Other (inactive) ingredients: Bovine Gelatin, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

HemodrauliX by Axis Labs Drug Interactions

Want to check YOUR meds against HemodrauliX?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,107Drugs
1,082 Moderate 25 Minor

Ingredients driving the most interactions

Grape Seed Extract 910
L-Arginine Alpha-Ketoglutarate 403
L-Citrulline Malate 178

Individual Drug Interactions

The ingredients in HemodrauliX interact with 1,107 drugs. Click any drug to see the details.

3 of the 5 ingredients in HemodrauliX interact with drugs. Each result below shows which ingredient is responsible. Grape Seed Extract L-Arginine Alpha-Ketoglutarate L-Citrulline Malate

Each ingredient & the kinds of drugs it affects

For each ingredient in HemodrauliX with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape Seed Extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape Seed Extract full monograph & interactions

L-Arginine Alpha-Ketoglutarate9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Alpha-Ketoglutarate full monograph & interactions

L-Citrulline Malate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline Malate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HemodrauliX, from the product label.

Axis Labs

See all Axis Labs products
Name
Axis Labs
City
Oakboro
State
NC
ZipCode
28129
Phone Number
+1-303-221-2110
Web Address
www.axislabs.com
Pharmacist Counseling Corner

HemodrauliX by Axis Labs: Common Questions

Does HemodrauliX by Axis Labs interact with any medications?
Yes. Based on its ingredients, HemodrauliX has a known interaction with 1,107 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HemodrauliX contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take HemodrauliX if I'm pregnant or breastfeeding?
The L-arginine in this product is rated possibly safe in pregnancy, but L-citrulline safety data advises against use during pregnancy—there isn't enough reliable information. For breastfeeding, L-citrulline should be avoided, and safety data for the L-arginine forms isn't on file. Grape seed extract is likely safe in both. Talk with your doctor or pharmacist before using this product if you're pregnant or breastfeeding.
What are the most common side effects of this product?
From the L-arginine content, expect possible abdominal pain, bloating, nausea, diarrhea, headache, insomnia, or flushing. Grape seed extract may cause abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, or nausea. L-citrulline can trigger gastrointestinal discomfort and heartburn. Most people tolerate it without serious issues.
Is this product safe to take with my blood pressure medication?
No—not without talking to your doctor first. The L-arginine in HemodrauliX can lower blood pressure, so combining it with blood pressure medications (including ACE inhibitors and ARBs) poses a moderate risk of dangerously low blood pressure. Check with your doctor or pharmacist before adding this product.
Can I use HemodrauliX if I take blood thinners like warfarin?
Not without talking to your doctor first. Both the L-arginine and grape seed extract in this product may increase bleeding risk when used with blood thinners or antiplatelet drugs. Get clearance from your doctor or pharmacist before starting.
Does this product actually work for improving blood flow and athletic performance?
The L-arginine and L-citrulline in this product aim to boost blood flow, but we don't hold effectiveness ratings for them. Grape seed extract shows possibly effective evidence for chronic venous insufficiency (a circulation condition in the legs), and L-citrulline shows possibly effective evidence for athletic performance based on the data we have.
How is L-citrulline different from L-arginine in this product?
Both are amino acids that support blood vessel relaxation, but L-citrulline works indirectly—your body converts it into L-arginine. HemodrauliX includes both to provide L-arginine in multiple forms, plus L-citrulline as an additional source. The interaction profiles and side effects are similar.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HemodrauliX label
Go deeper

The Full Monographs Behind HemodrauliX’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph →
Sources

Sources & How We Checked

HemodrauliX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 108 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
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Grape 34 references
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L-citrulline 8 references
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