Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

High Strength Prostaform Plus Ingredients & Drug Interactions

by Simply Supplements

High Strength Prostaform Plus label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Strength Prostaform Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Strength Prostaform Plus is a dietary supplement by Simply Supplements with 5 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 517 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine Hydrochloride, Zinc, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against High Strength Prostaform Plus by Simply Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with High Strength Prostaform Plus by Simply Supplements — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of High Strength Prostaform Plus by Simply Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “L-Arginine Hydrochloride” is listed as a grouped ingredient — the label gives one combined amount (120 mg) without saying how much of each component you get.

High Strength Prostaform Plus contains 5 active ingredients. L-glutamine and L-arginine (plus L-arginine hydrochloride, a salt form of the same amino acid) are building blocks your body uses for protein and cell function.

Zinc is a mineral essential for immune health and wound healing. Beta-alanine is an amino acid that may support physical performance.

Pumpkin seed extract is a plant concentrate—the supplement's main prostate-specific ingredient. The capsules also contain inactive ingredients: maltodextrin, gelatin, silica, and magnesium stearate, which are fillers, binders, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support normal prostate function.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Prostate health, Lower urinary tract symptoms, Urinary flow.
  • The strongest evidence on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Zinc is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH).

The data we hold shows effectiveness ratings only for individual ingredients, not the product as a whole. L-glutamine is effective for sickle cell disease and possibly effective for HIV-related weight loss, postoperative recovery, and critical illness.

Zinc is effective for zinc deficiency and likely effective for Wilson disease, with possibly effective ratings for acne and age-related macular degeneration. Beta-alanine is possibly effective for athletic and physical performance, but evidence is insufficient for cognitive function, COPD, or menopausal symptoms.

Pumpkin seed extract is possibly effective for benign prostatic hyperplasia (BPH)—the prostate enlargement this product seems aimed at—but evidence is insufficient for hair loss, bladder pain, parasites, or UTIs. We hold no effectiveness data for L-arginine in our monograph.

The evidence, ingredient by ingredient Glutamine Zinc Beta-alanine L-arginine Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated but should be used only under medical supervision in people with kidney or liver disease; it's not recommended in supplement doses during pregnancy or breastfeeding without doctor advice. Common side effects include belching, bloating, constipation, nausea, vomiting, diarrhea, headache, and GI pain, especially at high doses.

Rare cases of dizziness and mood changes (mania or hypomania) have been reported in people with bipolar disorder. Zinc is safe in recommended amounts but can cause abdominal cramps, diarrhea, metallic taste, nausea, and vomiting—all dose-related.

High doses above 40 mg daily may increase copper deficiency risk. L-arginine is often well tolerated short-term but can lower blood pressure and isn't studied for safe self-treatment; common effects include abdominal pain, bloating, nausea, diarrhea, headache, and flushing.

Beta-alanine is generally well tolerated but commonly causes harmless skin tingling (paresthesia) and flushing; it should be avoided in pregnancy and breastfeeding due to insufficient safety data. Pumpkin seed extract is generally safe as a supplement, though concentrated forms lack long-term safety data; rare cases of anaphylaxis and hair loss linked to high cucurbitacin (a natural compound) have been reported.

Side effects, ingredient by ingredient Glutamine Zinc Beta-alanine L-arginine Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Pumpkin, L-arginine, Glutamine, Zinc.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; lithium.
  • For scale: 517 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use anticonvulsants (seizure medications), any antibiotic type, blood pressure drugs (including ACE inhibitors or ARBs), blood thinners or antiplatelet drugs, diabetes medications, potassium-sparing diuretics, sildenafil (Viagra), lithium, or HIV medications. The most serious concern is L-glutamine's theoretical antagonism of anticonvulsants, followed by zinc's documented absorption-blocking effect on antibiotics and HIV drugs.

Arrange the timing of antibiotics and this supplement with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to men managing prostate concerns, given the pumpkin seed extract, though evidence for BPH is only possibly effective. The combination of amino acids and minerals is generally well tolerated, but the ingredient list and medication interactions are substantial—especially for anticonvulsants, antibiotics, blood pressure and blood thinner medications, and diabetes drugs.

Before you start, talk with your doctor or pharmacist about your exact medications and health conditions, particularly if you take any of the types mentioned.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Strength Prostaform Plus, straight from the product label.

Brand Simply Supplements
Barcode (UPC) 5060370563760
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Feb 24, 2017
DSLD ID 70785
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Seniors/Mature (>50 Years) - Men ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Strength Prostaform Plus by Simply Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
5060370563760
IngredientAmount% DV
L-Glutamine100 mg--
Zinc15 mg150%
L-Arginine100 mg--
Beta-Alanine50 mg--
L-Arginine Hydrochloride120 mg--
Pumpkin seed extract25 mg--

Other ingredients: Maltodextrin, Gelatin, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Combining active ingredients for men

Product Information Prostaform Plus has been specifically designed for the mature man, to incorporate natural ingredients which may help to support normal prostate function.

Seals/Symbols

Quality Assured

Suggested/Recommended/Usage/Directions

Suggested Daily Intake Take one to three capsules daily as a food supplement or as directed by a healthcare professional.

Precautions

Important Information If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of our products, always consult your GP or Pharmacist prior to taking supplements.

Do not exceed stated dose.

Keep away from children at all times.

Do not use if seal is broken.

Pregnant or lactating women should consult a doctor before using this product.

Allergy Advice: Contains an ingredient derived from Beef.

Food Supplement: This product should not be used as a substitute for a varied diet.

Storage

Store in a cool dry place.

General Statements

Image is for illustration purposes only.

EasyGest capsules ~ Easy to swallow ~ Easy to absorb ~ Easy to digest ~ No product odour ~ No bad taste

AutoDespatch Save 10% and get free P&P on all repeat orders by having your favourite supplements conveniently scheduled and delivered automatically with our unique AutoDespatch system. Same day despatch We will ensure your order is despatched on the day of receipt (when placed before 12.30pm) and that all orders placed after 12.30pm are despatched on the next working day. All sent 1st class!

PriceMatch guarantee! If you buy from us and then see the same product cheaper elsewhere we will refund the difference plus 10%!

NRV=Nutrient Reference Value

General

E635

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Strength Prostaform Plus by Simply Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Strength Prostaform Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Strength Prostaform Plus by Simply Supplements

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
100 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Zinc

Interacts with
67 drugs
15 mg per serving

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Beta-Alanine

No known
interactions
50 mg per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta-Alanine monograph & interactions

L-Arginine Hydrochloride

Interacts with
403 drugs
120 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Hydrochloride monograph & interactions

Pumpkin seed extract

Interacts with
1 drug
25 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed extract monograph & interactions

Other (inactive) ingredients: Maltodextrin, Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Strength Prostaform Plus by Simply Supplements Drug Interactions

Want to check YOUR meds against High Strength Prostaform Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
517Drugs
507 Moderate 10 Minor

Ingredients driving the most interactions

L-Arginine Hydrochloride 403
Zinc 67
L-Glutamine 50
Pumpkin seed extract 1

Individual Drug Interactions

The ingredients in High Strength Prostaform Plus interact with 517 drugs. Click any drug to see the details.

4 of the 5 ingredients in High Strength Prostaform Plus interact with drugs. Each result below shows which ingredient is responsible. L-Arginine Hydrochloride Zinc L-Glutamine Pumpkin seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in High Strength Prostaform Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine Hydrochloride9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Hydrochloride full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

Pumpkin seed extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Strength Prostaform Plus, from the product label.

Simply Supplements

See all Simply Supplements products
Name
Simply Supplements
Street Address
PO Box 1330
City
Peterborough
ZipCode
PE2 2PW
Phone Number
0800 988 0292
Pharmacist Counseling Corner

High Strength Prostaform Plus by Simply Supplements: Common Questions

Does High Strength Prostaform Plus by Simply Supplements interact with any medications?
Yes. Based on its ingredients, High Strength Prostaform Plus has a known interaction with 517 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Strength Prostaform Plus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Pregnancy and breastfeeding safety varies by ingredient. L-glutamine is rated likely safe in pregnancy but should be avoided in supplement doses while breastfeeding. L-arginine is possibly safe in pregnancy, with insufficient data for breastfeeding. Beta-alanine should be avoided in both pregnancy and breastfeeding. Pumpkin seed extract safety data isn't established for either. Talk with your doctor or pharmacist about whether this product is right for you.
What's the most common side effect?
Beta-alanine commonly causes a harmless tingling sensation (paresthesia) and flushing that usually starts on the scalp within 20 minutes and lasts about an hour. You'll also likely see GI side effects from L-glutamine and L-arginine—nausea, bloating, diarrhea, and abdominal discomfort—especially at higher doses.
Can I take this if I'm on an antibiotic?
No—not without adjusting timing. Zinc in this product binds to several common antibiotics (quinolones, tetracyclines, cephalexin, penicillamine) in your gut and blocks their absorption, making them less effective. Your pharmacist can help you space out the doses—usually at least 2 hours before or 4–6 hours after the antibiotic.
Does this actually help with prostate problems?
Pumpkin seed extract is possibly effective for benign prostatic hyperplasia (BPH)—enlarged prostate—but the evidence is preliminary, not conclusive. The other ingredients (glutamine, zinc, arginine, beta-alanine) aren't rated for prostate health in our data, so the full product's effectiveness for prostate concerns hasn't been established.
Will this lower my blood pressure?
L-arginine can lower blood pressure in some people, so if you already take blood pressure medication or drugs that affect potassium levels, this product may add to that effect and raise your risk of very low blood pressure or high potassium. Check with your doctor before starting.
Is there a safety concern with high doses of zinc?
Yes. Zinc above 40 mg daily can increase the risk of copper deficiency over time, which may lead to anemia and low white blood cells. Some doctors give a small copper dose alongside high-dose zinc to prevent this. Make sure your doctor knows if you're taking this supplement long-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Strength Prostaform Plus label
Go deeper

The Full Monographs Behind High Strength Prostaform Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

High Strength Prostaform Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 183 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
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See these in context on the Zinc monograph →

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Beta-alanine 13 references
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See these in context on the Beta-alanine monograph →

Pumpkin 5 references
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See these in context on the Pumpkin monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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