Hybrid N.O. By MusclePharm Overview & Drug Interactions

Niacin, also known as vitamin B3, is a water-soluble vitamin found in a variety of foods, including meat, poultry, fish, and fortified grains. It plays a variety of roles in the body, including in the metabolism of carbohydrates, fats, and proteins. It is also necessary for the production of energy in the body and in the synthesis of different hormones. Niacin deficiency is rare in developed countries, however, supplementation has been shown to have several positive benefits. For example, it can reduce the risk of diabetic neuropathy (i.e., nerve pain) and has been shown effective for treating some types of high cholesterol (extended-release niacin is used as a prescription drug in the United States for this purpose). There is a multitude of niacin forms available as dietary supplements, including NADH, niacinamide, and nicotinamide riboside, all with different properties.

Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Agmatine is an endogenous polyamine found in bacteria, plants, and animals, including humans, synthesized from the amino acid arginine. It plays a crucial role in various physiological processes, including neurotransmission, nitric oxide synthesis, and cellular metabolism. In dietary supplements, agmatine is proposed to support mental health, cognitive function, and overall well-being. It's most common use is as a pre and post-workout supplement.

Glycine is an amino acid found naturally in the body and is also available as a dietary supplement. It is considered a non-essential amino acid, meaning that the body can produce it on its own. Glycine supplementation has been studied for its potential to help improve sleep quality as it is purported to help to promote relaxation and reduce muscle tension. Some studies have also suggested that it may help to improve symptoms of sleep disorders such as insomnia. Glycine has also been studied for its potential to help with the management of some types of chronic pain, such as osteoarthritis, and for improving cognitive function.

Beetroot is a type of root vegetable belonging to the Chenopodiaceae family. It is commonly consumed as a food and utilized as a dietary supplement. Beetroot supplements are purported to have a number of potential health benefits, including lowering blood pressure by increasing the production of nitric oxide, improving exercise performance, and reducing inflammation. Dietary supplements containing beetroot are generally in powdered form, and are sometimes standardized by their nitrate content.

Hawthorn is a shrub native to Europe, Asia, and North America. It is a member of the rose family and is known for its thorny branches and small, white or pink flowers, which bloom in the spring. The fruit, called a haw, is a small red berry that is edible and often used in traditional medicine. Hawthorn has been used to treat a variety of conditions, including gastrointestinal discomfort, heart disease, high blood pressure, and chest pain. For its purported blood pressure-lowering abilities, it is thought to work by dilating blood vessels and improving blood flow to the heart. Hawthorn dietary supplements are typically standardized extracts of the berry, leaf and flower of the plant.