Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

L-Glutamine Alpha-Ketoglutarate Ingredients & Drug Interactions

by PureBulk.com

L-Glutamine Alpha-Ketoglutarate label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Glutamine Alpha-Ketoglutarate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Glutamine Alpha-Ketoglutarate is a dietary supplement by PureBulk.com with 2 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Glutamine Alpha-Ketoglutarate by PureBulk.com

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glutamine Alpha-Ketoglutarate by PureBulk.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Glutamine Alpha-Ketoglutarate by PureBulk.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: L-Glutamine and Alpha Ketoglutarate. L-Glutamine is an amino acid your body uses for muscle support, immune function, and gut health.

Alpha Ketoglutarate is a compound involved in cellular energy production. There are no inactive ingredients listed in this formulation.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glutamine's overall clinical evidence instead.

Strong

Strong clinical evidence supports Glutamine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Natural Medicines).
  • On file: Pancreatitis — rated "Possibly Effective" (Natural Medicines).

L-Glutamine is rated effective for sickle cell disease. It's rated possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

We hold no effectiveness data in our files for Alpha Ketoglutarate.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated in healthy adults, but if you have kidney or liver disease, use it only under medical supervision. The most common side effects from oral glutamine are gastrointestinal—belching, bloating, constipation, flatulence, diarrhea, nausea, and vomiting.

Headache and musculoskeletal pain have also been reported. High doses (10-30 grams daily) used in clinical trials were more likely to cause GI upset.

Rare cases of dizziness and mood changes (mania or hypomania) have been reported in people with bipolar disorder taking glutamine. There isn't enough reliable safety data to recommend glutamine supplements in pregnancy or while breastfeeding unless your doctor advises it.

We hold no safety information on Alpha Ketoglutarate.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (used to prevent seizures), check with your doctor or pharmacist before starting this product. The Moderate interaction is theoretical but worth confirming isn't a concern for your specific drug and dose.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

L-Glutamine Alpha-Ketoglutarate may be worth considering if you have sickle cell disease, are recovering from surgery, or are dealing with critical illness or HIV-related wasting—and only if your doctor supports it. The main caution is if you take anticonvulsant medications; check with your own doctor or pharmacist before adding this product.

People with kidney or liver disease, and those pregnant or breastfeeding, should talk it over with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine Alpha-Ketoglutarate, straight from the product label.

Brand PureBulk.com
Net contents 100 g; 3.53 oz.
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 23139
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine Alpha-Ketoglutarate by PureBulk.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
650 mg
Maximum serving Sizes:
1300 mg
Servings per container
83
IngredientAmount% DV
L-Glutamine867 mg--
Alpha Ketoglutarate433 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNING: Persons with liver or kidney disease, or Reye's syndrome should not use.

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children.

Storage

Storage: Keep dry, cool & dark

Formulation

Free of: sugar, soy, dairy, yeast, gluten, corn and additives.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 650 mg (scant 1/4 tsp) to 1300 mg (1/2 tsp) up to three times daily, or as directed by physician.

General Statements

US Standard Measuring Spoons Spoon Size (level) milligrams 1/8 teaspoon 328 1/4 teaspoon 657 1/2 teaspoon 1316

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Glutamine Alpha-Ketoglutarate by PureBulk.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Glutamine Alpha-Ketoglutarate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Glutamine Alpha-Ketoglutarate by PureBulk.com

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size650 mg Dosage formPowder Servings per container83 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
867 mg per serving Form: L-Glutamine Alpha-Ketoglutarate

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Alpha Ketoglutarate

433 mg per serving Form: L-Glutamine Alpha Ketoglutarate

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine Alpha-Ketoglutarate by PureBulk.com Drug Interactions

Want to check YOUR meds against L-Glutamine Alpha-Ketoglutarate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in L-Glutamine Alpha-Ketoglutarate interact with 50 drugs. Click any drug to see the details.

1 of the 2 ingredients in L-Glutamine Alpha-Ketoglutarate interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine Alpha-Ketoglutarate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Glutamine Alpha-Ketoglutarate, from the product label.

PureBulk.com

See all PureBulk.com products
Name
PureBulk.com
City
Roseburg
State
OR
ZipCode
97471
Phone Number
(541) 679-1500
Web Address
PureBulk.com
Pharmacist Counseling Corner

L-Glutamine Alpha-Ketoglutarate by PureBulk.com: Common Questions

Does L-Glutamine Alpha-Ketoglutarate by PureBulk.com interact with any medications?
Yes. Based on its ingredients, L-Glutamine Alpha-Ketoglutarate has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine Alpha-Ketoglutarate contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-Glutamine safe during pregnancy or while breastfeeding?
There isn't enough reliable safety data to recommend L-Glutamine supplements in pregnancy or breastfeeding unless your doctor specifically advises it. Talk with your doctor or pharmacist about whether it's right for your situation.
What are the most common side effects?
Gastrointestinal effects are most common—belching, bloating, constipation, flatulence, diarrhea, nausea, and vomiting. Headache and muscle pain have also been reported. Higher doses are more likely to cause GI upset.
Is L-Glutamine effective for muscle recovery after a workout?
The data we hold rates L-Glutamine possibly effective for postoperative recovery and critical illness. We don't have effectiveness information specifically for routine muscle recovery from exercise.
Can I take this if I have kidney or liver disease?
If you have kidney or liver disease, use L-Glutamine only under medical supervision. Talk with your doctor or pharmacist before starting.
What is Alpha Ketoglutarate, and why is it in this product?
Alpha Ketoglutarate is a compound involved in how your cells produce energy. We don't hold effectiveness data for it in our files, so I can't tell you what role it plays in this formulation specifically.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutamine Alpha-Ketoglutarate is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine Alpha-Ketoglutarate label
Go deeper

The Full Monographs Behind L-Glutamine Alpha-Ketoglutarate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

L-Glutamine Alpha-Ketoglutarate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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