Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Lactobacillus Reuteri Plus Ingredients & Drug Interactions

by Kirkman

Lactobacillus Reuteri Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lactobacillus Reuteri Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lactobacillus Reuteri Plus is a dietary supplement by Kirkman with 5 active ingredients. Its ingredients are commonly taken for digestive and gut health, source of soluble fiber, constipation or bowel regularity.Based on those ingredients, 2,080 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acacia Gum, Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lactobacillus Reuteri Plus by Kirkman

Ask about any prescription or over-the-counter medication and we check it for interactions with Lactobacillus Reuteri Plus by Kirkman — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lactobacillus Reuteri Plus by Kirkman

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Kirkman Proprietary Blend” is a proprietary blend — the label gives one combined amount (125 mg) without saying how much of each component you get.

Lactobacillus Reuteri Plus contains five active ingredients, all probiotics (beneficial bacteria) and one fiber. The three Lactobacillus species — L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri — are live microorganisms meant to support your gut flora.

Acacia Gum is a plant fiber that acts as a prebiotic, feeding those beneficial bacteria. The product also contains a Kirkman Proprietary Blend, whose specific formula isn't disclosed on the label.

The inactive ingredients — Hypromellose, Water, Silicon Dioxide, and L-Leucine — are fillers and binders that hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and balance support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Gum Arabic is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS).

The evidence for this product's individual bacteria is limited. Lactobacillus acidophilus is rated Possibly Effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

It's rated Possibly Ineffective for atopic disease (allergic conditions), and we don't have enough reliable evidence to rate it for acute respiratory distress syndrome. For Acacia Gum, the effectiveness data we hold doesn't support its use for metabolic syndrome, kidney failure, sickle cell disease, obesity, gingivitis, or peristomal lesions — evidence is insufficient to rate it for any of these.

The effectiveness of L. plantarum, L. rhamnosus, and L. reuteri is not established in our data.

The evidence, ingredient by ingredient Gum Arabic Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. That said, because these are live microorganisms, there's a theoretical concern that they could cause serious infection (bacteremia, sepsis, abscess, endocarditis, meningoencephalitis) in some patients — though most documented cases appear linked to translocation of bacteria already present in your body rather than the supplement itself.

Minor stomach upset — epigastric discomfort, abdominal pain, indigestion, gas, bloating, diarrhea, vomiting, and burping — can happen when taking L. acidophilus with other probiotics, but these are uncommon. In one trial, rash and itching were reported in a small number of participants, though it's unclear whether L. acidophilus caused them.

Acacia Gum is generally recognized as safe as a food additive, but high supplemental doses may cause digestive upset: abdominal bloating, gas, nausea, vomiting, cramping, and mild diarrhea were reported in studies. These effects may improve within 2 weeks of continued use.

For pregnancy, L. acidophilus is rated Possibly Safe, but we don't have enough safety information for either L. acidophilus or Acacia Gum during breastfeeding — talk with your doctor or pharmacist before using this product if you're nursing.

Side effects, ingredient by ingredient Gum Arabic Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Gum Arabic, Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,081 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take antibiotics — they can reduce the effectiveness of the live bacteria in this supplement, so you'll need to space out your doses. Also check if you take amoxicillin or other oral medications that are absorbed from the stomach and intestines, since Acacia Gum can interfere with how your body takes them in.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic blend may help with IBS, antibiotic-associated diarrhea, and a few other gut-related issues, though the evidence is modest. The main thing to watch is timing: if you take antibiotics, they'll kill the live bacteria in this supplement, so separate them by a few hours.

Some people will notice stomach gas or bloating at first, which usually settles down. Check your medications with your doctor or pharmacist before starting, especially if you're on antibiotics or other oral drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lactobacillus Reuteri Plus, straight from the product label.

Brand Kirkman
Barcode (UPC) 812325024636
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 297060
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lactobacillus Reuteri Plus by Kirkman, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
812325024636
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus rhamnosus0 NP--
Lactobacillus reuteri0 NP--
Acacia Gum162.5 mg--
Kirkman Proprietary Blend125 mg--

Other ingredients: Hypromellose, Water, Silicon Dioxide, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Important: Keep bottle refrigerated and tightly capped.

Precautions

Keep out of the reach of children.

Do not remove the desiccant bag or oxygen absorber if present.

Free of: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or soy

Seals/Symbols

Ultra Tested cGMP Certified Current Good Manufacturing Practices Consistent Quality

Formulation

Hypoallergenic

Gluten-free

Formula

10 Billion CFUs

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: One to two capsules daily or as directed by a physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lactobacillus Reuteri Plus by Kirkman label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lactobacillus Reuteri Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lactobacillus Reuteri Plus by Kirkman

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Acacia Gum

Interacts with
2,022 drugs
162.5 mg per serving

Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for dige...

Acacia Gum monograph & interactions

Kirkman Proprietary Blend

125 mg per serving

Other (inactive) ingredients: Hypromellose, Water, Silicon Dioxide, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lactobacillus Reuteri Plus by Kirkman Drug Interactions

Want to check YOUR meds against Lactobacillus Reuteri Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,080Drugs
2,080 Moderate

Ingredients driving the most interactions

Acacia Gum 2,022
Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Lactobacillus Reuteri Plus interact with 2,080 drugs. Click any drug to see the details.

2 of the 5 ingredients in Lactobacillus Reuteri Plus interact with drugs. Each result below shows which ingredient is responsible. Acacia Gum Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Lactobacillus Reuteri Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Acacia Gum2 drug types · 2,022 drugs

Amoxicillin (Amoxil, Trimox)

Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.

Likelihood Probable Evidence B
Oral Drugs

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.

Likelihood Possible Evidence B
Acacia Gum full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lactobacillus Reuteri Plus, from the product label.

Kirkman

See all Kirkman products
Name
Kirkman
City
Lake Oswego
State
OR
ZipCode
97035
Phone Number
(800) 245-8282
Web Address
www.kirkmangroup.com
Pharmacist Counseling Corner

Lactobacillus Reuteri Plus by Kirkman: Common Questions

Does Lactobacillus Reuteri Plus by Kirkman interact with any medications?
Yes. Based on its ingredients, Lactobacillus Reuteri Plus has a known interaction with 2,080 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lactobacillus Reuteri Plus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will antibiotics ruin this probiotic?
Yes — antibiotics kill the live bacteria in Lactobacillus acidophilus, which defeats the purpose of taking them together. If you're on antibiotics, separate your doses from this supplement by a few hours so the bacteria aren't destroyed before they can do their job. Ask your doctor or pharmacist about the best timing for your specific antibiotic.
Can I take this while pregnant?
Lactobacillus acidophilus is rated Possibly Safe during pregnancy, but we don't have solid safety data on Acacia Gum or the other bacteria in this product during pregnancy. Talk with your doctor or pharmacist before starting it — they know your individual situation and can give you personalized advice.
Can I take this while breastfeeding?
We don't have enough data on the safety of either the Lactobacillus species or Acacia Gum during breastfeeding. Check with your doctor or pharmacist to see if this product is right for you while nursing.
What kind of stomach side effects should I expect?
Some people get gas, bloating, nausea, diarrhea, or cramping — especially when combining multiple probiotics. These effects are usually mild and uncommon, and may go away within 2 weeks if you keep taking it. If they don't improve or get worse, stop and talk with your pharmacist.
Does this help with IBS?
Lactobacillus acidophilus is rated Possibly Effective for IBS, which means there's some evidence it may help, but the data isn't strong or complete. Your results may vary, and it's worth checking with your doctor to see if it makes sense for your symptoms.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lactobacillus Reuteri Plus is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lactobacillus Reuteri Plus label
Go deeper

The Full Monographs Behind Lactobacillus Reuteri Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gum Arabic

Interacts with 2,022 drugs

Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...

Read the full Gum Arabic monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Lactobacillus Reuteri Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Gum Arabic 8 references
  1. Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
  2. Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
  3. Babiker R, Merghani TH, Elmusharaf K, et al. Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial. Nutr J 2012;11:111. PubMed
  4. Babiker R, Elmusharaf K, Keogh MB, Banaga AS, Saeed AM. Metabolic effect of gum Arabic (Acacia senegal) in patients with type 2 diabetes mellitus (T2DM): randomized, placebo controlled double blind trial. Functional Foods in Health and Disease. 2017;7(3): DOI
  5. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed
  6. Ali NE, Kaddam LA, Alkarib SY, et al. Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial. Int J Nephrol. 2020;2020:7214673.
  7. Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of acacia gum (E 414) as a food additive. EFSA J. 2017;15(4):e04741. PubMed
  8. Larson R, Nelson C, Korczak R, et al. Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects. Nutrients 2021;13(2):618. PubMed

See these in context on the Gum Arabic monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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