Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

LeptiPure 500 mg Ingredients & Drug Interactions

by OptiChoice

LeptiPure 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LeptiPure 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

LeptiPure 500 mg is a dietary supplement by OptiChoice with 2 active ingredients. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 1,020 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are GymnePURE 8X organic Gymnema sylvestre extract, TinosPURE Tinospora cordifolia extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against LeptiPure 500 mg by OptiChoice

Ask about any prescription or over-the-counter medication and we check it for interactions with LeptiPure 500 mg by OptiChoice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of LeptiPure 500 mg by OptiChoice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “LeptiPURE” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

LeptiPure 500 mg is a two-ingredient capsule combining GymnePURE 8X Gymnema sylvestre extract and TinosPURE Tinospora cordifolia extract. Each is listed as an active ingredient; the capsule shell itself is the only inactive ingredient listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight loss and metabolic balance with blood glucose support.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Hyperlipidemia, Hypertriglyceridemia, Metabolic syndrome, Obesity — and 2 related terms.
  • The strongest evidence on file: Tinospora Cordifolia is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Obesity, Impaired glucose tolerance (prediabetes), Metabolic syndrome.
  • Also on file: Tinospora Cordifolia is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertriglyceridemia.

The evidence for what these ingredients actually accomplish is limited. Tinospora cordifolia is rated possibly effective for diabetes based on clinical research showing it can lower fasting blood glucose and a measure of long-term blood sugar control.

Gymnema sylvestre, however, is rated insufficient evidence for diabetes, obesity, and prediabetes — meaning we don't have solid proof yet that it works for those purposes. Neither ingredient has established effectiveness for other conditions the product may be marketed for.

The evidence, ingredient by ingredient Gymnema Tinospora Cordifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both extracts are generally well tolerated when used short-term, though quality varies between products. The main concern is low blood sugar if you take antidiabetes medication.

More seriously, rare cases of liver injury have been reported with both ingredients — Gymnema has caused drug-induced hepatitis and hepatitis-associated aplastic anemia (a serious blood disorder) in individual cases; Tinospora cordifolia has caused autoimmune hepatitis, acute hepatitis, and acute liver failure in 49 patients documented across case series, with 2 requiring transplant and 4 deaths. Tinospora cordifolia is rated unsafe in pregnancy and breastfeeding; Gymnema is also rated unsafe in pregnancy and while breastfeeding due to insufficient safety data.

Neither ingredient should be used during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Gymnema Tinospora Cordifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Gymnema, Tinospora Cordifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,021 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take LeptiPure, check with your doctor or pharmacist if you take antidiabetes drugs — both ingredients may lower your blood sugar further and increase hypoglycemia risk. Also flag any drugs processed by liver enzymes CYP2C9, CYP2D6, CYP2C19, or CYP1A2 (including some blood thinners, antidepressants, and pain relievers), immunosuppressants, or phenacetin.

Your pharmacist can run your specific medications through the interaction tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

LeptiPure is a two-ingredient herbal supplement with limited evidence of effectiveness and real concerns about interactions with medications — especially diabetes drugs and many common prescriptions metabolized by your liver. Because of the potential for low blood sugar and rare but serious liver injury, this is not something to take on your own without checking with your doctor or pharmacist first, especially if you take any prescription medications, have diabetes, or have liver disease.

Pregnant people and those breastfeeding should not use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LeptiPure 500 mg, straight from the product label.

Brand OptiChoice
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 217017
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LeptiPure 500 mg by OptiChoice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
LeptiPURE500 mg--
GymnePURE 8X organic Gymnema sylvestre extract0 NP--
TinosPURE Tinospora cordifolia extract0 NP--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

OSA Technology Optimal absorption and bioavailability LeptiPure is a patented, synergistic combination of two powerful botanical extracts that supports stable blood glucose levels and healthy cholesterol & triglyceride levels; all while promoting healthy weight management and aiding in blood pressure modulation; all critical metabolic health markers. OSA technology captures the most potent and bio-active parts of the plant to deliver superior health benefits such as optimizing the ratio of vital hormones Leptin (lower is better) and Adiponectin (higher is better responsible for supporting healthy weight management naturally. LeptiPure supports the natural balance of weight management hormones

Patented OSA Technology Nutritional support for healthy weight loss and metabolic balance

No preservatives / No excipients / Gluten free

Brand IP Statement(s)

US Patents #6,949,261, #6,946,151 #8,936,817

LeptiPure is exclusively licensed to SourceOne Global Partners.

Vcaps is a registered trademark of capsugel. For more information, please visit www.opti-choice.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 or more capsules daily with a meal or as directed by your healthcare professional or pharmacist.

Storage

Storage: Keep tightly closed in a cool, dry place in the original container. Do not expose to excessive heat.

Precautions

Keep out of the reach of children.

Caution: Do not use if seal is broken.

As with any dietary supplements, please consult a medical professional before using if you are pregnant, lactating, or have any existing medical condition.

Seals/Symbols

Vcaps

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LeptiPure 500 mg by OptiChoice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LeptiPure 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LeptiPure 500 mg by OptiChoice

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

LeptiPure 500 mg by OptiChoice Drug Interactions

Want to check YOUR meds against LeptiPure 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,020Drugs
612 Moderate 408 Minor

Ingredients driving the most interactions

GymnePURE 8X organic Gymnema sylvestre extract 851
TinosPURE Tinospora cordifolia extract 612

Individual Drug Interactions

The ingredients in LeptiPure 500 mg interact with 1,020 drugs. Click any drug to see the details.

2 of the 2 ingredients in LeptiPure 500 mg interact with drugs. Each result below shows which ingredient is responsible. GymnePURE 8X organic Gymnema sylvestre extract TinosPURE Tinospora cordifolia extract

Each ingredient & the kinds of drugs it affects

For each ingredient in LeptiPure 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

GymnePURE 8X organic Gymnema sylvestre extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
GymnePURE 8X organic Gymnema sylvestre extract full monograph & interactions

TinosPURE Tinospora cordifolia extract6 drug types · 612 drugs

Antidiabetes Drugs

Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.

Likelihood Possible Evidence D
TinosPURE Tinospora cordifolia extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LeptiPure 500 mg, from the product label.

OptiChoice

See all OptiChoice products
Name
OptiChoice The Natural Choice for Optimal Health
Street Address
445 E. Illinois ST.
City
Chicago
State
IL
ZipCode
60611
Phone Number
1-800-755-4996
Pharmacist Counseling Corner

LeptiPure 500 mg by OptiChoice: Common Questions

Does LeptiPure 500 mg by OptiChoice interact with any medications?
Yes. Based on its ingredients, LeptiPure 500 mg has a known interaction with 1,020 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LeptiPure 500 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this supplement actually work for weight loss or blood sugar?
Tinospora cordifolia is rated possibly effective for diabetes, with clinical studies showing it can lower fasting blood glucose. Gymnema sylvestre, the other main ingredient, does not have solid evidence yet — we don't know for sure whether it works for weight loss, diabetes, or prediabetes. Neither ingredient is proven for other uses they may be marketed for.
Can I take this if I'm on diabetes medication?
You need to check with your doctor or pharmacist before taking it. Both extracts in this product can lower blood sugar on their own, and they may enhance the effect of your diabetes drugs — which could cause dangerously low blood sugar. Do not start it without clearing it first.
Are there any serious side effects I should know about?
Rare cases of liver injury have been reported with both ingredients. In Tinospora cordifolia, these include hepatitis and in some serious cases, liver failure requiring transplant. While uncommon, this is a real risk — if you develop jaundice, fatigue, or dark urine while taking this supplement, stop it and contact your doctor right away.
Is this safe during pregnancy or breastfeeding?
No. Both ingredients are rated unsafe in pregnancy and while breastfeeding because there isn't enough safety data. If you're pregnant or breastfeeding, do not use this product.
What are the main ingredients in one capsule?
The two active ingredients are GymnePURE 8X Gymnema sylvestre extract and TinosPURE Tinospora cordifolia extract, housed in a vegetable capsule. That's the product — no fillers or other active ingredients beyond those two.
Can this interact with my blood pressure or cholesterol medication?
Possibly. Both extracts may affect how your body processes drugs metabolized by certain liver enzymes (CYP2C9, CYP2D6, CYP2C19, CYP1A2). Some blood pressure and cholesterol drugs go through these pathways. Use the interaction checker below with your exact medication names, or ask your pharmacist to screen them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if LeptiPure 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LeptiPure 500 mg label
Go deeper

The Full Monographs Behind LeptiPure 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph → Herb & supplement monograph

Tinospora Cordifolia

Interacts with 612 drugs

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies s...

Read the full Tinospora Cordifolia monograph →
Sources

Sources & How We Checked

LeptiPure 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Tinospora Cordifolia 16 references
  1. Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
  3. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
  4. Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
  5. Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
  6. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
  7. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
  8. Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
  9. Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
  10. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
  11. Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  15. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
  16. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

See these in context on the Tinospora Cordifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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