Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Lutigold Extra Ingredients & Drug Interactions

by Puritan's Pride

Lutigold Extra label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutigold Extra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutigold Extra is a dietary supplement by Puritan's Pride with 3 active ingredients. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutigold Extra by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutigold Extra by Puritan's Pride — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lutigold Extra by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Lutigold Extra Blend” is a proprietary blend — the label gives one combined amount (20 mg) without saying how much of each component you get.

Lutigold Extra is a 3-ingredient softgel that combines two forms of zeaxanthin and lutein. Zeaxanthin and lutein are carotenoids — plant pigments your eye uses to filter light and protect the retina.

This product delivers them in concentrated supplement form, so you're getting more than you'd typically eat in food.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: healthy eyes and macular vision.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Zeaxanthin and lutein are both possibly effective for age-related macular degeneration (AMD), the eye condition that can blur central vision as you age. Lutein is also possibly effective for cataracts.

The evidence for zeaxanthin and lutein in age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and lung problems in premature infants is insufficient — we don't have enough reliable data to rate them either way.

The evidence, ingredient by ingredient Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both zeaxanthin and lutein are generally well tolerated at typical supplement doses. Lutein in particular has been tested up to 20 mg daily without adverse effects reported.

For pregnancy, the safety data advises caution with concentrated supplements — food sources are fine, but supplement safety hasn't been well studied. The same applies to breastfeeding: lutein occurs naturally in breast milk, but higher supplement doses haven't been enough studied.

Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Zeaxanthin Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (pills or insulin for blood sugar control), check with your doctor or pharmacist before adding this product. Zeaxanthin may increase the risk of low blood sugar.

No interactions are documented for lutein in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lutigold Extra makes sense if you're looking to support eye health, especially if you have early signs of age-related macular degeneration or are concerned about cataracts. The main thing to watch for is if you take diabetes medication — zeaxanthin theoretically could lower your blood sugar further.

Check your exact medications with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutigold Extra, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077211791
Net contents 15 Easy to Swallow Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 239775
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutigold Extra by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
025077211791
IngredientAmount% DV
Zeaxanthin0 NP--
Lutigold Lutein0 NP--
Meso-Zeaxanthin0 NP--
Lutigold Extra Blend20 mg--

Other ingredients: Gelatin, Soy Bean Oil, Vegetable oil, Vegetable Glycerin, Contains <2% of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Healthy eyes Ingredients for vision & macular health

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

Puritan’s Pride supplements are produced from the finest raw materials under stringent quality control standards.

Formula

Meso-Zeaxanthin & Zeaxanthin Eye Care with Lutigold

When choosing Lutein, make sure it's Lutigold!

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel one to two times daily, preferably with meals.

General Statements

State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health…choose the best.

To reorder Item # 21179 www.puritan.com 1-800-645-1030

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2017 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutigold Extra by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutigold Extra label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutigold Extra by Puritan's Pride

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutigold Extra Blend

20 mg per serving

Other (inactive) ingredients: Gelatin, Soy Bean Oil, Vegetable oil, Vegetable Glycerin, Contains <2% of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutigold Extra by Puritan's Pride Drug Interactions

Want to check YOUR meds against Lutigold Extra?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Lutigold Extra interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Lutigold Extra interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutigold Extra with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutigold Extra, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Lutigold Extra by Puritan's Pride: Common Questions

Does Lutigold Extra by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Lutigold Extra has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutigold Extra contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Lutigold Extra actually prevent age-related macular degeneration?
The evidence says lutein and zeaxanthin are possibly effective for AMD — meaning there's some support, but it's not a guarantee. They're protective nutrients your eye needs, especially if you're already at risk. Talk with your eye doctor about whether this fits your prevention plan.
Is it safe to take if I'm pregnant?
There isn't enough data on concentrated supplements during pregnancy — food sources are fine. Because the safety hasn't been well studied, use caution and talk with your doctor before starting.
Can I take this while breastfeeding?
Lutein is naturally in breast milk, and the supplement form is rated as likely safe — but higher doses haven't been well studied. Talk with your doctor or pharmacist to make sure it's right for your situation.
What are zeaxanthin and lutein actually for?
They're carotenoids — plant pigments your retina needs to filter light and stay healthy. They build up in the back of your eye and act as a kind of natural sunscreen for sensitive tissue.
Does Lutigold Extra have any fillers or other junk in it?
It contains gelatin, soy bean oil, vegetable oil, vegetable glycerin, and trace other ingredients as the capsule and base — those are standard for softgels. The active ingredients are zeaxanthin and lutein.
I take insulin for diabetes. Can I use this?
Zeaxanthin might lower blood sugar further, so there's a moderate concern with antidiabetes drugs. Check with your doctor or pharmacist before starting — they know your doses and can advise whether it's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutigold Extra is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutigold Extra label
Go deeper

The Full Monographs Behind Lutigold Extra’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Lutigold Extra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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