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Dietary supplement

Manganese 50 mg Ingredients & Drug Interactions

by NaturesPlus

Manganese 50 mg label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Manganese 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Manganese 50 mg is a dietary supplement by NaturesPlus with 1 active ingredient. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 83 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Manganese 50 mg by NaturesPlus

Ask about any prescription or over-the-counter medication and we check it for interactions with Manganese 50 mg by NaturesPlus — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Manganese 50 mg by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is a single-ingredient supplement: manganese, a mineral your body uses for bone health, metabolism, and immune function. The tablet also contains several inactive ingredients — microcrystalline cellulose, cellulose, stearic acid, dicalcium phosphate, silica, magnesium stearate, and pharmaceutical glaze — which are fillers, binders, and coating materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: protein fat metabolism energy production bone joint health.
  • We looked for evidence on: Manganese deficiency, Osteoarthritis, Osteoporosis, Wound healing, Cartilage formation, Synovial fluid support — and 1 related terms.
  • The strongest evidence on file: Manganese is rated "Effective" for Manganese deficiency (Natural Medicines).
  • Also on file: Manganese is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis, Osteoarthritis, Wound healing.

Manganese 50 mg is effective for treating manganese deficiency, a rare condition. For hay fever (allergic rhinitis), osteoporosis, COPD, weight loss (obesity), and osteoarthritis, the evidence we hold is insufficient to rate it — meaning we don't have solid data either way on whether it actually works for these uses.

The evidence, ingredient by ingredient Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Manganese in normal dietary amounts is well tolerated, but high-dose supplements carry real risk. The safety data here advises caution: high doses can cause neurotoxicity — nerve damage resembling Parkinson's disease — in rare cases.

One documented case involved a person taking 100 mg daily for 2–4 years who developed irreversible Parkinson-like symptoms. There's also concern that high-dose manganese exposure may harm the liver, causing cirrhosis and fatty liver damage in severe cases.

Stick to the recommended dose and don't exceed it without advice from your doctor.

Side effects, ingredient by ingredient Manganese

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Manganese.
  • The most serious interaction on file is rated Moderate.
  • For scale: 83 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NaturesPlus Manganese, double-check with your pharmacist if you're on antipsychotic drugs, quinolone antibiotics, or tetracycline antibiotics. All three groups have Moderate-severity interactions with manganese that may affect how the drugs work or increase toxicity risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is appropriate if you have a confirmed manganese deficiency and your doctor recommends it. If you take an antipsychotic or any antibiotic — especially quinolone (like cipro) or tetracycline (like doxycycline) types — talk to your pharmacist before starting.

High doses carry a real risk of nerve damage, so don't exceed the label dose.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Manganese 50 mg, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467034501
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 318928
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Manganese 50 mg by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
097467034501
IngredientAmount% DV
Manganese50 mg2174%

Other ingredients: Microcrystalline Cellulose, Cellulose, Stearic Acid, Dicalcium Phosphate, Silica, Magnesium Stearate, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Manganese promotes protein and fat metabolism, energy production, healthy nerves, immune defenses and blood sugar regulation. It also supports the formation of cartilage and synovial fluid of the joints, promotes normal bone growth and supports healthy reproductive functions.

Manufactured with the Biotron Process of amino acid chelation.

Storage

Keep tightly closed in a cool, dry place.

Precautions

Keep out of reach of children.

High-Potency Manganese - consult you doctor or qualified healthcare practitioner before taking.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Overall Wellness

Vegetarian

Free from synthetic: colors, preservations. Gluten Free

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: One tablets daily.

Brand IP Statement(s)

Copyright Natural Organics

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Manganese 50 mg by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Manganese 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Manganese 50 mg by NaturesPlus

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Manganese

Interacts with
83 drugs
50 mg per serving Form: Soy Amino Acid Chelate

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Stearic Acid, Dicalcium Phosphate, Silica, Magnesium Stearate, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Manganese 50 mg by NaturesPlus Drug Interactions

Want to check YOUR meds against Manganese 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
83Drugs
83 Moderate

Ingredients driving the most interactions

Manganese 83

Individual Drug Interactions

The ingredients in Manganese 50 mg interact with 83 drugs. Click any drug to see the details.

1 of the 1 ingredient in Manganese 50 mg interact with drugs. Each result below shows which ingredient is responsible. Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Manganese 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Manganese 50 mg, from the product label.

NaturesPlus

See all NaturesPlus products
Name
Natural Organics, Inc. makers of NaturesPlus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
NY
ZipCode
11701
Web Address
naturesplus.com
Pharmacist Counseling Corner

Manganese 50 mg by NaturesPlus: Common Questions

Does Manganese 50 mg by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Manganese 50 mg has a known interaction with 83 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Manganese 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is manganese supposed to do?
Manganese is a mineral your body needs for bone health, metabolism, and immune function. This supplement is proven effective for treating manganese deficiency. For other uses like hay fever, osteoporosis, and arthritis, we don't have solid evidence it works.
Is this supplement safe to take long-term?
Not in high doses. Manganese at normal dietary amounts is well tolerated, but high-dose supplements over time can cause nerve damage resembling Parkinson's disease. One case reported here involved 100 mg daily for 2–4 years leading to irreversible symptoms. Stick to the recommended dose and don't go above it without your doctor's approval.
Can manganese harm my liver?
High-dose manganese exposure has been linked to liver damage, including cirrhosis and fatty liver, in severe cases. Normal dietary amounts are not a concern, but supplements at high doses carry this risk. That's why the safety data cautions against extra high-dose supplements unless a clinician advises otherwise.
Does this interact with antibiotics?
Yes — manganese may reduce how well certain antibiotics are absorbed, making them less effective. This applies to quinolone antibiotics (like ciprofloxacin) and tetracycline antibiotics (like doxycycline). If you're on either type, talk to your pharmacist about spacing your doses or adjusting your plan.
Is it safe to take during pregnancy or while breastfeeding?
We don't have safety data on file for this product during pregnancy or breastfeeding. The general caution notes that normal dietary manganese is appropriate, but high-dose supplements should be avoided unless a clinician advises it. Talk with your doctor or pharmacist for personalized guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Manganese 50 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Manganese 50 mg label
Go deeper

The Full Monographs Behind Manganese 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

Manganese 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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