Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Manganese Concentrate Ingredients & Drug Interactions

by Complete H2O Minerals

Manganese Concentrate label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Manganese Concentrate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Manganese Concentrate is a dietary supplement by Complete H2O Minerals with 2 active ingredients. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 83 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Manganese Concentrate by Complete H2O Minerals

Ask about any prescription or over-the-counter medication and we check it for interactions with Manganese Concentrate by Complete H2O Minerals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Manganese Concentrate by Complete H2O Minerals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This liquid contains manganese, a mineral your body needs for bone health, metabolism, and nerve function. The product also contains chloride and is delivered in purified water.

Because it's a liquid concentrate, you get the mineral in a form that's easy to measure and absorb.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Essential for brain, muscle and joint function.
  • We looked for evidence on: Manganese deficiency, Osteoarthritis, Wound healing, Bone health, Enzyme function, Cartilage formation.
  • The strongest evidence on file: Manganese is rated "Effective" for Manganese deficiency (Natural Medicines).
  • Also on file: Manganese is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Wound healing.

Manganese is effective for treating manganese deficiency — a real but uncommon condition. For hay fever (allergic rhinitis), bone health (osteoporosis), chronic obstructive pulmonary disease, weight management, and osteoarthritis, the evidence we hold isn't strong enough to say whether manganese helps.

If you're considering this for any of those uses, talk with your doctor about whether testing or supplementation makes sense for you.

The evidence, ingredient by ingredient Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Manganese in normal dietary amounts is generally well tolerated. However, high-dose supplements carry real risks.

High doses can cause neurotoxicity — nerve damage including Parkinson-like symptoms — and there is one documented case of severe, irreversible Parkinson disease linked to 100 mg daily for 2 to 4 years. Very high doses can also harm your liver, causing cirrhosis and fatty liver changes.

One case report describes a young person who developed life-threatening neurological symptoms and liver damage from manganese intoxication. For breastfeeding, amounts in normal food and prenatal vitamins are appropriate, but the safety data on extra high-dose supplements during lactation is unclear or raises concern — avoid high-dose supplements unless your doctor advises it.

We hold no data on safety during pregnancy for this product.

Side effects, ingredient by ingredient Manganese

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Manganese.
  • The most serious interaction on file is rated Moderate.
  • For scale: 83 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any antipsychotic medications (like haloperidol or phenothiazines), quinolone antibiotics (like ciprofloxacin or levofloxacin), or tetracycline antibiotics (like doxycycline or tetracycline). Manganese may worsen toxicity risk with antipsychotics and reduce how well antibiotics work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is useful if you have a manganese deficiency and your doctor recommends supplementing. If you take antipsychotics, quinolone or tetracycline antibiotics, or have any liver condition, check with your doctor or pharmacist before starting — high doses of manganese carry real neurotoxicity and liver risks.

Keep your dose in the normal dietary range unless a clinician tells you otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Manganese Concentrate, straight from the product label.

Brand Complete H2O Minerals
Barcode (UPC) 188671000434
Net contents 32 Oz(s); 1 Quart(s); 946 mL
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 180158
Product type Mineral
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Manganese Concentrate by Complete H2O Minerals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 tsp
Maximum serving Sizes:
1 tsp
Servings per container
192
UPC/BARCODE
188671000434
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 NP--
Manganese250 mcg3%
Total Fat0 NP--
Chloride330 mcg--

Other ingredients: purified Water, Manganese Chloride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Manganese is essential for normal brain and muscle function. It is also necessary for forming the cushioning material between the joints. Manganese is also key in many enzyme functions, acting as a catalyst for utilization of choline, biotin, ascorbic acid, and thiamine.

General Statements

In processing, FDA & GMP guidelines are observed and strictly followed.

Quality products for a quality life!

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease.

FDA Statement of Identity

Dietary Supplement

Storage

For best results, store in a cool, dark place and use within six months.

Suggested/Recommended/Usage/Directions

For best results, store in a cool, dark place and use within six months.

Recommended Dosage: Adults: 1 Tsp. 250 mcg Children: 1/2 Tsp. 125 mcg or as recommended by a health care professional.

Precautions

Note: Do not use if tamper seal is broken or missing.

Formulation

Complete H2O Minerals contain no preservatives, fillers or artificial ingredients.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Manganese Concentrate by Complete H2O Minerals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Manganese Concentrate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Manganese Concentrate by Complete H2O Minerals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 tsp Dosage formLiquid Servings per container192 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Manganese

Interacts with
83 drugs
250 mcg per serving

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Chloride

330 mcg per serving

Other (inactive) ingredients: Purified Water, Manganese Chloride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Manganese Concentrate by Complete H2O Minerals Drug Interactions

Want to check YOUR meds against Manganese Concentrate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
83Drugs
83 Moderate

Ingredients driving the most interactions

Manganese 83

Individual Drug Interactions

The ingredients in Manganese Concentrate interact with 83 drugs. Click any drug to see the details.

1 of the 2 ingredients in Manganese Concentrate interact with drugs. Each result below shows which ingredient is responsible. Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Manganese Concentrate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Manganese Concentrate, from the product label.

Complete H2O Minerals

See all Complete H2O Minerals products
Name
Complete H2O Minerals
Street Address
707 Greenwood Road
City
West Columbia
State
SC
ZipCode
29169
Pharmacist Counseling Corner

Manganese Concentrate by Complete H2O Minerals: Common Questions

Does Manganese Concentrate by Complete H2O Minerals interact with any medications?
Yes. Based on its ingredients, Manganese Concentrate has a known interaction with 83 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Manganese Concentrate contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with my hay fever or arthritis?
The evidence we hold isn't established enough to say manganese relieves hay fever or osteoarthritis. If you're considering it for either condition, your doctor can help you decide whether a trial makes sense for you and what dose would be appropriate.
What happens if I take too much?
High-dose manganese can damage your nerves, causing Parkinson-like symptoms that may become permanent, and can harm your liver. There's one case of severe, irreversible Parkinson disease linked to taking 100 mg daily for years, and another of a young person who developed life-threatening neurological and liver damage. Stick to normal dietary amounts unless your doctor advises otherwise.
Is it safe while I'm breastfeeding?
Normal amounts in food and prenatal vitamins are fine. High-dose supplements during breastfeeding raise safety concerns — talk with your doctor or pharmacist before taking this if you're nursing.
Why would I take this if I don't have a manganese deficiency?
Most people get enough manganese from food, so supplements are most useful when your doctor confirms you're actually deficient. For other uses — bone health, weight, or breathing — the evidence isn't clear enough to recommend it, so those decisions belong with your healthcare provider.
Can I take this with my antibiotics?
Manganese may reduce how well quinolone and tetracycline antibiotics are absorbed, which could make them less effective. Check with your doctor or pharmacist about spacing or choosing a different time to start the supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Manganese Concentrate is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Manganese Concentrate label
Go deeper

The Full Monographs Behind Manganese Concentrate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

Manganese Concentrate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team