Major interaction on record — check this product against your medications before combining. Based on 7 of 9 ingredients. Check your meds →
Dietary supplement

Morphodonis Ingredients & Drug Interactions

by MN Morphogen Nutrition

Morphodonis label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Morphodonis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Morphodonis is a dietary supplement by MN Morphogen Nutrition with 9 active ingredients. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 760 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Red Yeast Rice, Hawthorn Berry Extract, Saw Palmetto Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Morphodonis by MN Morphogen Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Morphodonis by MN Morphogen Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Morphodonis by MN Morphogen Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Morphodonis contains 9 active ingredients: pregnenolone (a hormone precursor), Lepidamax (maca), damiana (an herbal extract), HMRLignan, CardioAid, red yeast rice (a fermented rice containing the statin lovastatin), hawthorn berry extract (for cardiovascular support), saw palmetto extract (traditionally used for prostate health), and pygeum (also for prostate health). The product also contains gelatin, titanium dioxide, and FD&C Blue #1 as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Benign prostatic hyperplasia (BPH) — rated "Likely Effective" (Pygeum) (Natural Medicines).
  • On file: HIV/AIDS-related dyslipidemia — rated "Possibly Effective" (Red Yeast Rice) (Natural Medicines).
  • On file: Myocardial infarction (MI) — rated "Possibly Effective" (Red Yeast Rice) (Natural Medicines).
  • On file: Transurethral resection of the prostate (TURP) — rated "Possibly Effective" (Saw Palmetto) (Natural Medicines).

The evidence for most of these ingredients is limited. Pregnenolone, damiana, hawthorn, and saw palmetto all show insufficient reliable evidence for the conditions they're traditionally used for—meaning clinical trials haven't established whether they work.

Red yeast rice is possibly effective for HIV/AIDS-related dyslipidemia and possibly effective for reducing heart attack risk, though its statin-like action carries real safety concerns. Pygeum is likely effective for benign prostatic hyperplasia (enlarged prostate), but long-term safety data are sparse.

For HMRLignan and CardioAid, we hold no effectiveness data.

The evidence, ingredient by ingredient Pregnenolone Maca Damiana Red Yeast Rice Hawthorn Saw Palmetto Pygeum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated but is a hormone with limited human safety data and should only be used under a healthcare professional's guidance. Common side effects can include acne, agitation, diarrhea, drowsiness, and hair loss.

Damiana and hawthorn are generally well tolerated in typical amounts, though damiana has caused serious neurological effects at very high doses and hawthorn warrants caution in people with heart conditions. Red yeast rice works like a prescription statin and carries similar risks—it's generally well tolerated but can rarely cause liver damage or muscle breakdown (rhabdomyolysis).

Saw palmetto is well tolerated, with mild and usually reversible side effects like digestive upset and headache, though rare cardiovascular effects have been reported. Pygeum is generally well tolerated short-term.

None of these ingredients have adequate safety data in pregnancy or breastfeeding, and the facts advise against use in both.

Side effects, ingredient by ingredient Pregnenolone Maca Damiana Red Yeast Rice Hawthorn Saw Palmetto Pygeum

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Pregnenolone, Hawthorn, Damiana, Red Yeast Rice, Saw Palmetto.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 761 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use nitrates or phosphodiesterase-5 inhibitors (Major severity). Also important to verify: blood pressure medications (especially beta-blockers and calcium channel blockers), blood thinners (anticoagulants and antiplatelet drugs), diabetes medications, statins or other cholesterol drugs, liver-damaging medications, antifungal drugs, cyclosporine, gemfibrozil, high-dose niacin, benzodiazepines, estrogen-containing medications, or birth control pills.

No interactions are documented for the ingredients we could not check (HMRLignan and CardioAid).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This is a complex product with multiple ingredients that interact with common medications, especially blood pressure drugs, blood thinners, diabetes medications, and statins. If you take any prescription medication—particularly for the heart, blood pressure, blood clotting, diabetes, or cholesterol—talk with your doctor or pharmacist before starting.

Even without prescriptions, hawthorn's Major-severity interactions with certain cardiac and erectile dysfunction drugs make medical clearance important. This product is not intended for pregnant or breastfeeding people.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Morphodonis, straight from the product label.

Brand MN Morphogen Nutrition
Barcode (UPC) 787790056096
Net contents 240 Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261176
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Qualified Health, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Morphodonis by MN Morphogen Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Capsule(s)
Maximum serving Sizes:
8 Capsule(s)
Servings per container
30
UPC/BARCODE
787790056096
IngredientAmount% DV
Pregnenolone10 mg--
Lepidamax2100 mg--
Damiana800 mg--
HMRLignan30 mg--
CardioAid800 mg--
Red Yeast Rice600 mg--
Hawthorn Berry Extract550 mg--
Saw Palmetto Extract400 mg--
Pygeum200 mg--

Other ingredients: Gelatin, Titanium Dioxide, FD&C Blue#1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended use: As a dietary supplement, take 8 capsules per day in divided doses, preferably with meals. Exceeding recommended daily dosage is not advised.

Precautions

Exceeding recommended daily dosage is not advised.

Warnings: Not intended for use by persons under the age of 18.

If you are pregnant or nursing or taking any prescription medications, consult your health care professional before using this or any other dietary supplement product.

Contact your healthcare professional before using this or any other dietary supplement product. Immediately discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Allergen information: This product is manufactured in a facility that processes other products which may contain soy, dairy, wheat, tree nuts, shellfish, fish, peanuts, and eggs.

Brand IP Statement(s)

Lepidamax and its associated logo are registered trademarks of Nutrition 21, LLC. Lepidamax is patent protected. CardioAid and CardioAid logo are registered trademarks of Archer Daniels Midland Company. HMRlignan is a trademark used under sublicense from Linnea S.A.

Morphogen Nutrition Join the takeover

Storage

Store in a cool, dry place and avoid excessive heat.

Formula

Total Men's Health

With Lepidamax HMRlignan CardioAid plant sterols

Pure Ingredients

Formulation

Libido Lipids Prostate

High Potency Formula Maximum Performance

May assist with: Libido and sexual health Performance and vitality Energy production Blood flow and circulation Overall lipid profile Metabolic syndrome and cardiovascular disease risk Prostate health Hormone regulation

FDA Statement of Identity

Dietary Supplement

General Statements

Morphogen Nutrition specializes in developing no BS, scientifically validated, effectively dosed and affordable sports nutrition supplements Knowledge Honesty Integrity No BS

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Manufactured in the USA for Morphogen Nutrition GMP Good Manufacturing Practice Quality Product FDA Registered Facility 3rd Party Certified for Purity & Potency Lab Tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Morphodonis by MN Morphogen Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Morphodonis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Morphodonis by MN Morphogen Nutrition

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pregnenolone

Interacts with
82 drugs
10 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Lepidamax

No known
interactions
2100 mg per serving Form: Maca Root Extract

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...

Lepidamax monograph & interactions

Damiana

Interacts with
86 drugs
800 mg per serving Form: Turnera aphrodisiaca

Damiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is...

Damiana monograph & interactions

HMRLignan

30 mg per serving Form: Norway Spruce Extract

CardioAid

800 mg per serving Form: Plant Sterol Ester

Red Yeast Rice

Interacts with
477 drugs
600 mg per serving Form: Monascus purpureus

Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Be...

Red Yeast Rice monograph & interactions

Hawthorn Berry Extract

Interacts with
191 drugs
550 mg per serving Form: Hawthorn Flower Extract, Hawthorn Leaf Extract, Hyperoside, Vitexin

Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when...

Hawthorn Berry Extract monograph & interactions

Saw Palmetto Extract

Interacts with
174 drugs
400 mg per serving Form: Fatty Acids, Serenoa repens, Sterols

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto Extract monograph & interactions

Pygeum

No known
interactions
200 mg per serving Form: Pygeum africanum Bark Extract, Sterols

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...

Pygeum monograph & interactions

Other (inactive) ingredients: Gelatin, Titanium Dioxide, FD&C Blue#1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Morphodonis by MN Morphogen Nutrition Drug Interactions

Want to check YOUR meds against Morphodonis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
760Drugs
14 Major 746 Moderate

Ingredients driving the most interactions

Red Yeast Rice 477
Hawthorn Berry Extract 191
Saw Palmetto Extract 174
Damiana 86
Pregnenolone 82

Individual Drug Interactions

The ingredients in Morphodonis interact with 760 drugs. Click any drug to see the details.

5 of the 9 ingredients in Morphodonis interact with drugs. Each result below shows which ingredient is responsible. Red Yeast Rice Hawthorn Berry Extract Saw Palmetto Extract Damiana Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Morphodonis with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Red Yeast Rice6 drug types · 477 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, taking red yeast rice in combination with cyclosporine might increase the risk of myopathy.
Red yeast rice contains varying levels of the statin drug lovastatin. Cyclosporine has been reported to increase plasma levels of lovastatin by 5- to 20-fold, resulting in reports of myopathy and rhabdomyolysis.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.
Red yeast rice contains varying levels of the statin drug lovastatin, which is metabolized by CYP3A4. Combining red yeast rice with CYP3A4 inhibitors might increase serum levels of lovastatin from red yeast rice.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, taking red yeast rice in combination with gemfibrozil might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin. Gemfibrozil has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might increase the risk of liver damage.
Red yeast rice contains varying levels of the drug lovastatin. Lovastatin can cause liver damage in some people. Some clinical research suggests that supplements containing red yeast rice might increase liver enzyme levels in some, but not all, participants. Cases of acute hepatitis have been associated with red yeast rice. Combining it with hepatotoxic drugs might further increase this risk.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, taking red yeast rice with other statins might increase the risk of potential adverse effects.
Red yeast rice contains varying levels of the statin drug lovastatin and might result in supratherapeutic levels when used with other statins. Based on evaluation of data from the US Food and Drug Administration's adverse event reporting system (FAERS), it is recommended that red yeast rice products be avoided in people taking prescription statins.

Likelihood Probable Evidence D
Niacin

Theoretically, taking red yeast rice in combination with high-dose niacin might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin and has been linked to reports of myopathy. Niacin has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.

Likelihood Probable Evidence D
Red Yeast Rice full monograph & interactions

Hawthorn Berry Extract6 drug types · 191 drugs

Nitrates

Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Probable Evidence D
Phosphodiesterase-5 Inhibitors

Theoretically, concomitant use might result in additive vasodilation and hypotension.
Hawthorn might inhibit PDE-5 and cause vasodilation.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that hawthorn can inhibit platelet aggregation. However, its effect in humans is unclear. One observational study shows that patients taking hawthorn shortly before undergoing coronary artery bypass graft (CABG) surgery or valve replacement surgery have a 10% incidence of postoperative bleeding, compared with 1% in those who never consumed hawthorn extract. However, clinical research shows that taking a specific preparation of dried hawthorn leaves and flowers (Crataesor, Soria Natural Lab) 800 mg three times daily for 15 days does not affect platelet aggregation or levels of thromboxane B2, the metabolite of thromboxane A2, in healthy humans.

Likelihood Possible Evidence D
Beta-Blockers

Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Some evidence shows that hawthorn might lower blood pressure and heart rate.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.
Hawthorn appears to improve cardiac output; however, hawthorn does not appear to affect digoxin pharmacokinetics. Case reports suggest that at least one species of hawthorn root extract (Crataegus mexicana) may produce adverse effects similar to digoxin and can cross-react with digoxin assays, leading to falsely elevated plasma digoxin levels.

Likelihood Possible Evidence D
Hawthorn Berry Extract full monograph & interactions

Saw Palmetto Extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto Extract full monograph & interactions

Damiana1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that taking damiana lowers blood glucose level.

Likelihood Possible Evidence D
Damiana full monograph & interactions

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Morphodonis, from the product label.

MN Morphogen Nutrition

See all MN Morphogen Nutrition products
Name
Morphogen Nutrition
Street Address
4013 Kelly Ct.
City
Dublin
State
OH
ZipCode
43016
Web Address
www.mntakeover.com
Pharmacist Counseling Corner

Morphodonis by MN Morphogen Nutrition: Common Questions

Does Morphodonis by MN Morphogen Nutrition interact with any medications?
Yes. Based on its ingredients, Morphodonis has a known interaction with 760 medications, including 14 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Morphodonis contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any ingredients I should avoid if I'm on blood pressure medication?
Yes. Hawthorn berry extract and pregnenolone may both lower blood pressure, so combining them with your medication could cause your blood pressure to drop too far. Red yeast rice may also interact with certain blood pressure drugs. Talk with your doctor or pharmacist about whether this product is right for you.
Can I take this if I'm on a statin for cholesterol?
Probably not without medical guidance. Red yeast rice contains lovastatin, a statin drug, and combining it with prescription statins risks raising drug levels dangerously high and increasing the chance of muscle damage or liver problems. Check with your doctor first.
What are the most common side effects?
Pregnenolone may cause acne, agitation, diarrhea, drowsiness, or hair loss. Saw palmetto and damiana can cause mild digestive upset, headache, and dizziness. Red yeast rice may cause abdominal discomfort, diarrhea, dizziness, or headache. Most side effects are mild and reversible.
Is this safe to take if I'm pregnant or breastfeeding?
No. The ingredients don't have adequate safety data in pregnancy or breastfeeding, and several carry hormone effects that make use unsafe during these times. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before considering this product.
What is red yeast rice, and why does it worry me if I'm on heart medication?
Red yeast rice is fermented rice that contains lovastatin, the active ingredient in prescription statin drugs. Because it's a statin, it can interact with other heart and blood pressure medications—especially blood thinners, some cholesterol drugs, and certain immune and antifungal medications—raising the risk of serious muscle or liver problems. It's best to clear it with your doctor.
Can this product reduce how well my birth control works?
Yes. Saw palmetto has antiestrogenic effects and may reduce the effectiveness of estrogen-containing birth control and other estrogen medications. If you rely on hormonal contraception, talk with your doctor or pharmacist before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Morphodonis label
Go deeper

The Full Monographs Behind Morphodonis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Damiana

Interacts with 86 drugs

Damiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is generally well tolerated in the small am...

Read the full Damiana monograph → Herb & supplement monograph

Red Yeast Rice

Interacts with 477 drugs

Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Because of this, it carries the same risks...

Read the full Red Yeast Rice monograph → Herb & supplement monograph

Hawthorn

Interacts with 191 drugs

Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when added to standard care. However, the ev...

Read the full Hawthorn monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph →
Sources

Sources & How We Checked

Morphodonis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

Damiana 2 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
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Red Yeast Rice 50 references
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Hawthorn 25 references
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Saw Palmetto 22 references
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Pygeum 3 references
  1. Ishani A, MacDonald R, Nelson D, et al. Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. Am J Med 2000;109:654-64.. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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