Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

NattoPine Ingredients & Drug Interactions

by nbi

NattoPine label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NattoPine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NattoPine is a dietary supplement by nbi with 2 active ingredients. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NattoPine by nbi

Ask about any prescription or over-the-counter medication and we check it for interactions with NattoPine by nbi — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NattoPine by nbi

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NattoPine contains 2 active ingredients. Nattokinase is an enzyme derived from a fermented soy product called natto; it's been studied for cardiovascular effects.

The product also contains Masson Pine Bark Extract, though we have no detailed information on file about its role or effects. The capsule also includes inactive ingredients: hypromellose (a capsule binder), rice flour, and L-leucine (a branched-chain amino acid used as an excipient).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: healthy blood clotting and circulation.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Peripheral arterial disease (PAD), Venous insufficiency — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD), and more.

The evidence on nattokinase for its intended uses is not established in our data. We hold effectiveness ratings for nattokinase across several conditions — angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome — but all are rated as having insufficient reliable evidence.

We have no effectiveness data on file for Masson Pine Bark Extract in this product.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but its blood-thinning effect means people with any bleeding risk should be cautious. In rare cases, it's been linked to hemorrhage.

Some people can have allergic reactions to nattokinase or related compounds in natto, including serious reactions like anaphylaxis, usually within 2 hours of taking it. There isn't enough safety data on nattokinase during pregnancy, so the data advises against it.

Safety while breastfeeding is unknown, so it's best to avoid it if you're nursing. Talk with your doctor or pharmacist before using it if you're pregnant, trying to conceive, or breastfeeding.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start NattoPine, double-check it with your pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, apixaban, dabigatran, rivaroxaban, and others) — there's a Moderate risk of increased bleeding. Also mention any blood pressure medications you take, since nattokinase may lower pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

NattoPine is built on nattokinase, an ingredient with real interactions with blood thinners and blood pressure medications — especially important if you take aspirin or warfarin. The evidence for what it actually does isn't established yet.

If you have any bleeding risk, take blood pressure or blood-thinning medications, or are pregnant or nursing, check with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NattoPine, straight from the product label.

Brand nbi
Barcode (UPC) 718122061655
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317250
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NattoPine by nbi, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
718122061655
IngredientAmount% DV
Nattokinase182.5 mg--
Masson Pine Bark Extract300 mg--

Other ingredients: Hypromellose, Rice Flour, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Purity and potency guaranteed.

The Nattopine Difference: Formula based on clinical trials. Promotes healthy blood clotting and circulation.

Cardiovascular support

This product contains no wheat, gluten, soy, sodium, sugar, artificial coloring, preservatives or flavoring.

Storage

Storage: Keep tightly closed in a dry place; do not expose to excessive heat.

Precautions

Caution: If you have a medical condition, or are taking blood-thinning medications (eg. Warfarin or Levenox), check with your healthcare provider before taking this product.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 2 capsules daily with meals, or as directed by a healthcare professional.

Brand IP Statement(s)

Copyright 2019 All Rights Reserved - Nutritional Biochemistry, Inc.

General Statements

Formulated by physicians from Harvard, Cornell, MIT and Bastyr nbi Supporting life

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NattoPine by nbi label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NattoPine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NattoPine by nbi

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Nattokinase

Interacts with
289 drugs
182.5 mg per serving

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Masson Pine Bark Extract

300 mg per serving

Other (inactive) ingredients: Hypromellose, Rice Flour, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

NattoPine by nbi Drug Interactions

Want to check YOUR meds against NattoPine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in NattoPine interact with 289 drugs. Click any drug to see the details.

1 of the 2 ingredients in NattoPine interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in NattoPine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NattoPine, from the product label.

nbi

See all nbi products
Name
NBI
Street Address
3525 Del Mar Heights Rd # 350
City
San Diego
State
CA
ZipCode
92130
Phone Number
800-624-1416
Web Address
www.nbihealth.com
Pharmacist Counseling Corner

NattoPine by nbi: Common Questions

Does NattoPine by nbi interact with any medications?
Yes. Based on its ingredients, NattoPine has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NattoPine contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with aspirin?
Not without checking with your pharmacist first. Nattokinase has blood-thinning effects, and there's a documented case of someone who got brain bleeding after taking nattokinase while on low-dose aspirin. Your pharmacist can review your dose and situation.
Is nattokinase proven to work for heart health?
The evidence isn't established yet in our data. We don't have reliable evidence to support its use for angina, atherosclerosis, cardiovascular disease, or other conditions it's marketed for. That doesn't mean it doesn't work — just that the evidence isn't solid enough to rate it yet.
Can I take it if I'm on blood pressure medication?
You need to check with your pharmacist. Nattokinase may lower blood pressure on its own, so combining it with your medication could push your pressure too low. It's a Moderate interaction that needs personalized review.
Is it safe during pregnancy?
No. There isn't enough safety data, so the data advises against taking nattokinase when you're pregnant. Talk to your doctor before starting it if you're trying to conceive or are pregnant.
What's nattokinase made from?
Nattokinase is an enzyme from natto, a fermented soy product used in Japanese cuisine. If you have a known allergy to natto or soy, be aware that some people can have allergic reactions to nattokinase, including serious ones.
What are the inactive ingredients?
The capsule contains hypromellose, rice flour, and L-leucine. These are excipients — binders and fillers that help form and deliver the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NattoPine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NattoPine label
Go deeper

The Full Monographs Behind NattoPine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

NattoPine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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