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Dietary supplement

Pantethine 450 mg Ingredients & Drug Interactions

by Jarrow Formulas

Pantethine 450 mg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pantethine 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pantethine 450 mg is a dietary supplement by Jarrow Formulas with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pantethine 450 mg by Jarrow Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Pantethine 450 mg by Jarrow Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pantethine 450 mg by Jarrow Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pantethine 450 mg per softgel. Pantethine is a form of pantothenic acid (vitamin B5) that your body uses in energy metabolism and the production of certain hormones and cholesterol.

The capsule also contains inactive ingredients—bovine gelatin, glycerin, water, and annatto—which are the shell, lubricant, and color.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Lipid metabolism and cellular energy support.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, Triglyceride metabolism, Fatty acid oxidation.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

Pantethine is rated possibly effective for hyperlipoproteinemia (high blood lipid levels). For athletic performance, pantothenate kinase-associated neurodegeneration (PKAN), and other forms of hyperlipidemia, the evidence we hold is insufficient to rate whether it works.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild gastrointestinal complaints: nausea, vomiting, diarrhea, bloating, flatulence, and stomach discomfort.

Mild itching has been reported rarely. Because long-term safety data are limited, it's best to avoid pantethine unless your doctor advises otherwise.

There is not enough reliable data on pantethine's safety during pregnancy and breastfeeding; talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs—such as warfarin, aspirin, clopidogrel, or similar medications—check with your own pharmacist or doctor before starting pantethine. These combinations may carry a Moderate risk of increased bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pantethine may help with high blood lipid levels, though evidence varies by condition. The main caution is if you take blood thinners or antiplatelet drugs—the combination could increase bleeding risk.

If you're on any such medication, check with your own doctor or pharmacist before starting. Long-term safety data are sparse, so use it only under medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pantethine 450 mg, straight from the product label.

Brand Jarrow Formulas
Barcode (UPC) 790011180067
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 307706
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pantethine 450 mg by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
790011180067
IngredientAmount% DV
Pantethine450 mg--

Other ingredients: Bovine Gelatin, Glycerin, Water, Annatto

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 1 softgel once a day with a meal or as directed by your qualified healthcare professional.

Formula

Jarrow Formulas Pantethine is a derivative of pantothenic acid (vitamin B5) and a precursor in the formation of coenzyme A (CoA), an essential cofactor for lipid, carbohydrate, and protein metabolism. In cells, CoA is essential for fatty acid transport and fatty acid metabolism. Pantethine also helps to support normal healthy lipid metabolism.

Pantesin Vitamin B derivative

Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use. Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Pantesin is a trademark of Daiichi Pharmaceutical Co., Ltd. and is licensed to Daiichi fine chemicals.

Copyright 2022 Jarrow Formulas

Formulation

Supports normal carbohydrate and lipid metabolism

Non-GMO Gluten free

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.

Note: Color variation due to nature of material.

FDA Statement of Identity

Dietary Supplement

General Statements

Heart support

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pantethine 450 mg by Jarrow Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pantethine 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pantethine 450 mg by Jarrow Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Pantethine

Interacts with
122 drugs
450 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Other (inactive) ingredients: Bovine Gelatin, Glycerin, Water, Annatto. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pantethine 450 mg by Jarrow Formulas Drug Interactions

Want to check YOUR meds against Pantethine 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in Pantethine 450 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pantethine 450 mg interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pantethine 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pantethine 450 mg, from the product label.

Jarrow Formulas

See all Jarrow Formulas products
Name
Jarrow Formulas, Inc.
City
Sherman Oaks
State
CA
ZipCode
91403
Phone Number
1-866-459-4154
Pharmacist Counseling Corner

Pantethine 450 mg by Jarrow Formulas: Common Questions

Does Pantethine 450 mg by Jarrow Formulas interact with any medications?
Yes. Based on its ingredients, Pantethine 450 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pantethine 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pantethine, and why is it in this supplement?
Pantethine is a form of pantothenic acid (vitamin B5) that your body needs for energy production and hormone and cholesterol synthesis. This supplement delivers 450 mg per capsule.
Will pantethine help my cholesterol?
Pantethine is possibly effective for hyperlipoproteinemia (a blood lipid disorder). For other types of high cholesterol, the evidence we hold is not strong enough to say whether it works.
What are the most common side effects?
The most common side effects are mild gastrointestinal complaints: nausea, vomiting, diarrhea, bloating, flatulence, and stomach discomfort. Mild itching has been reported rarely.
Is it safe to take during pregnancy or breastfeeding?
There isn't enough reliable data to know whether pantethine is safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether it's right for you.
Why is the safety data limited?
Pantethine is generally well tolerated in studies, but long-term safety data are sparse. That's why it's best to take it only under medical guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pantethine 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pantethine 450 mg label
Go deeper

The Full Monographs Behind Pantethine 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Pantethine 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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