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Dietary supplement

Pau D'Arco Extract Ingredients & Drug Interactions

by NOW

Pau D'Arco Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco Extract is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d’Arco extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco Extract by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco Extract by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco Extract by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This liquid extract contains one active ingredient: pau d'arco extract. Pau d'arco is derived from the inner bark of a South American tree and has been used in traditional medicine, though modern evidence for its effectiveness is limited.

The extract is suspended in water, vegetable glycerin, and grain alcohol as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for pau d'arco doesn't establish that it works for cancer, peptic ulcers, wound healing, or dysmenorrhea — the data rated for each of these is insufficient. If you're considering this supplement for any of these uses, talk with your doctor or pharmacist about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco extract should be avoided during pregnancy due to possible harm to the developing baby and lack of safety data. It should also be avoided while breastfeeding because there isn't enough safety information.

At higher doses — particularly the lapachol constituent at doses above 1.5 grams daily — it may cause anemia, increased bleeding risk, severe nausea, vomiting, and diarrhea. Human safety data for this product is limited, so use with caution.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, double-check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs — such as warfarin, apixaban, dabigatran, aspirin, or clopidogrel. Pau d'arco may increase your bleeding risk when combined with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'Arco Extract by NOW is best avoided during pregnancy and breastfeeding. If you take blood thinners or antiplatelet medications, check with your doctor or pharmacist before using it.

The evidence for its traditional uses isn't well established, so discuss with your healthcare provider whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco Extract, straight from the product label.

Brand NOW
Barcode (UPC) 733739049100
Net contents 2 fl. Oz.; 59 mL
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 244786
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco Extract by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.8 mL
Maximum serving Sizes:
1.6 mL
Servings per container
37
UPC/BARCODE
733739049100
IngredientAmount% DV
Pau d’Arco extract1.6 mL--

Other ingredients: Water, Vegetable Glycerin, Grain Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 to 2 droppersful in tea or water 1 to 3 times daily.

Formula

Pau D’Arco is derived from the inner bark of a tree growing in the Amazonian rainforest. It has been used by traditional herbalists for centuries. Our extract is concentrated to highlight some of the active components naturally present in Pau D’Arco that may support healthy cell growth and have free radical scavenging properties.

Triangle K (Kosher)

Botanicals/herbs

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Not to be used by pregnant or nursing women. Consult physician if taking medication, or have a medical condition.

Contains alcohol, keep out of reach of children.

Contains alcohol, keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry, dark place after opening.

Formulation

Free radical scavenger Supports healthy cells

Non GMO

Vegetarian/vegan

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP Quality Assured

General Statements

Family owned since 1968.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco Extract by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco Extract by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.8 mL Dosage formLiquid Servings per container37 Amounts shown are per serving.

Pau d’Arco extract

Interacts with
122 drugs
1.6 mL per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d’Arco extract monograph & interactions

Other (inactive) ingredients: Water, Vegetable Glycerin, Grain Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco Extract by NOW Drug Interactions

Want to check YOUR meds against Pau D'Arco Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d’Arco extract 122

Individual Drug Interactions

The ingredients in Pau D'Arco Extract interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco Extract interact with drugs. Each result below shows which ingredient is responsible. Pau d’Arco extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d’Arco extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d’Arco extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco Extract, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Pau D'Arco Extract by NOW: Common Questions

Does Pau D'Arco Extract by NOW interact with any medications?
Yes. Based on its ingredients, Pau D'Arco Extract has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
No. The safety data advises against pau d'arco during pregnancy due to possible harm to your baby. There isn't enough safety information for breastfeeding either, so avoid it then too. Talk with your doctor or midwife if you're considering any herbal supplement during pregnancy or while nursing.
What does pau d'arco actually do?
Pau d'arco has been used traditionally for several purposes — cancer, peptic ulcers, wound healing, and period pain — but the evidence we hold doesn't establish that it works for any of them. If you're thinking about using it for a specific health issue, ask your doctor whether the current research supports it.
Are there side effects at normal doses?
At higher doses — particularly when the lapachol in pau d'arco exceeds 1.5 grams daily — it can cause anemia, increased bleeding risk, nausea, vomiting, and diarrhea. Human safety data is limited, so stick to the label dose and talk with your pharmacist if you have concerns.
Why do I need to check this with my doctor if I take blood thinners?
Pau d'arco may increase your bleeding risk when combined with blood thinners or antiplatelet drugs. Research shows it reduces platelet clumping and may interfere with vitamin K, which could make your medication work differently. Your doctor needs to know before you start.
Is this extract pure, or does it have fillers?
The extract is mixed with water, vegetable glycerin, and grain alcohol — these are inactive ingredients that help deliver the pau d'arco and keep it stable as a liquid. If you're avoiding alcohol, note that grain alcohol is included as a preservative.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco Extract label
Go deeper

The Full Monographs Behind Pau D'Arco Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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