Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Pure Joint Support Ingredients & Drug Interactions

by Shape by HIT Nutrition

Pure Joint Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Joint Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Joint Support is a dietary supplement by Shape by HIT Nutrition with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 702 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Joint Support by Shape by HIT Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Joint Support by Shape by HIT Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure Joint Support by Shape by HIT Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Pure Joint Support Proprietary Blend” is a proprietary blend — the label gives one combined amount (492.50 mg) without saying how much of each component you get.
  • “Hyal-Joint” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Pure Joint Support contains five active ingredients. Hesperidin is a plant compound (flavonoid); high-molecular-weight hyaluronic acid is a naturally occurring substance found in joint fluid that may support tissue hydration and lubrication.

The product also includes polysaccharides, collagen, and xanthohumol — each playing a role in joint support — as well as two proprietary blends that house additional components. The capsule also contains inactive ingredients: HPMC (capsule material), rice flour, ascorbyl palmitate, and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Joint mobility and comfort support.
  • We looked for evidence on: Osteoarthritis, Exercise-induced muscle soreness, Rheumatoid arthritis (RA), Joint flexibility, Cartilage health, Joint stiffness.
  • The closest evidence on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA).
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Osteoarthritis.

The effectiveness data we hold applies to hesperidin. For weight loss (obesity), hesperidin is rated possibly ineffective.

For cholesterol (hypercholesterolemia), it's also rated possibly ineffective. For fatty liver disease, evidence isn't reliable enough to rate it.

Hyaluronic acid is rated possibly effective for dry eye and venous leg ulcers. For aging skin, hay fever, and sexual dysfunction, the evidence is insufficient to rate it.

We hold no effectiveness ratings for polysaccharides, collagen, or xanthohumol.

The evidence, ingredient by ingredient Hesperidin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hesperidin is generally well tolerated in food amounts and short-term supplement use, though long-term data is limited. A rare case of allergic skin rash was reported in one older adult after topical application.

The safety data advises against hesperidin during pregnancy and breastfeeding. Hyaluronic acid appears well tolerated when taken orally or applied topically in most adults, but long-term safety of oral supplements isn't fully studied.

Safety data advises caution and suggests avoiding oral supplements unless your doctor clears it. Topically, it may cause itching, redness, eczema, or wound infection in some people.

No pregnancy or breastfeeding safety information is on file for hyaluronic acid. We hold no safety data for polysaccharides, collagen, or xanthohumol.

Side effects, ingredient by ingredient Hesperidin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 702 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check hesperidin's interactions if you take any CNS depressants (sleeping pills, anxiety or pain medications that sedate), antihypertensive drugs (blood pressure medications), blood thinners or antiplatelet drugs, verapamil, diltiazem, or celiprolol. No interactions are documented for hyaluronic acid in our data, though we could not check polysaccharides, collagen, or xanthohumol.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking at joint support and don't take blood pressure drugs, blood thinners, heart medications, or sedating drugs, this product may be worth exploring — but run your medications through our checker first. Anyone on verapamil, diltiazem, celiprolol, or CNS depressants should talk with their pharmacist before adding it.

Pregnancy and breastfeeding: discuss with your doctor or pharmacist for personalized advice.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Joint Support, straight from the product label.

Brand Shape by HIT Nutrition
Barcode (UPC) 0637801369403
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2015
DSLD ID 51289
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Joint Support by Shape by HIT Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
0637801369403
IngredientAmount% DV
Polysaccharides0 NP--
Collagen0 NP--
Hesperidin0 NP--
Pure Joint Support Proprietary Blend492.5 mg--
Hyal-Joint0 NP--
high-molecular-weight Hyaluronic Acid0 NP--
Xanthohumol0 NP--

Other ingredients: HPMC, Rice Flour, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Joint Mobility Support

Pure Joint Support Meets or Exceeds cGMP Quality Standards

This package is completely recyclable

Pure Joint Support is a breakthrough formula designed for active adults who don't want to slow down or reduce their ability to perform athletic tasks–from walking to extreme sports. It promotes healthy joint fluid and synovial membranes, supports joint mobility, and helps support cytokine and eicosanoid balance. Keep the fluid in your joints healthy just as you would change the oil in your car to get more mileage. Let Pure Joint Support help you stay active and perform well!*

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Hyal-Joint

Vegetable Capsules

H

Brand IP Statement(s)

Hyal-Joint is a registered trademark licensed by Bioiberica, S.A.

General

REV. 042514 064339-01

Precautions

STORAGE: Keep tightly closed in a cool, dry place out of reach of children.

Consult your healthcare practitioner prior to use.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Do not use if tamper seal is damaged.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one capsule twice daily, or as directed by your healthcare practitioner.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep tightly closed in a cool, dry place out of reach of children.

Formulation

DOES NOT CONTAIN: Wheat, gluten, corn, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Joint Support by Shape by HIT Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Joint Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Joint Support by Shape by HIT Nutrition

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pure Joint Support Proprietary Blend

492.5 mg per serving

Other (inactive) ingredients: HPMC, Rice Flour, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Joint Support by Shape by HIT Nutrition Drug Interactions

Want to check YOUR meds against Pure Joint Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
702Drugs
702 Moderate

Ingredients driving the most interactions

Hesperidin 702

Individual Drug Interactions

The ingredients in Pure Joint Support interact with 702 drugs. Click any drug to see the details.

1 of the 3 ingredients in Pure Joint Support interact with drugs. Each result below shows which ingredient is responsible. Hesperidin

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Joint Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D
Hesperidin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Joint Support, from the product label.

Shape by HIT Nutrition

See all Shape by HIT Nutrition products
Name
HIT Nutrition
Street Address
16070 N. Elder
City
Nampa
State
ID
ZipCode
83687
Web Address
www.hitnutrition.com
Pharmacist Counseling Corner

Pure Joint Support by Shape by HIT Nutrition: Common Questions

Does Pure Joint Support by Shape by HIT Nutrition interact with any medications?
Yes. Based on its ingredients, Pure Joint Support has a known interaction with 702 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Joint Support contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against hesperidin during pregnancy and breastfeeding due to lack of information. Hyaluronic acid has no pregnancy or breastfeeding safety data on file. Talk with your doctor or pharmacist — they can weigh the risks and benefits for your situation.
Will this actually help my joints?
The evidence we hold on hesperidin shows it's likely ineffective for weight loss and cholesterol, and there isn't enough data to rate it for other conditions. Hyaluronic acid is possibly effective for dry eye and leg ulcers, but evidence for joint support itself isn't established in our data.
Is hyaluronic acid safe to take by mouth?
Oral hyaluronic acid appears well tolerated in most adults, but long-term safety of supplements isn't fully studied. The safety notes suggest avoiding oral supplements unless your doctor advises otherwise.
What are the side effects?
Hesperidin and hyaluronic acid are generally well tolerated. A rare allergic skin rash was reported with topical hesperidin. Topical hyaluronic acid may cause itching, redness, or eczema in some people. Most people taking this supplement by mouth don't report side effects in the data we hold.
Does this product have fillers?
The capsule contains inactive ingredients: HPMC (the capsule material itself), rice flour, ascorbyl palmitate, and silica. These are standard excipients used in supplements.
Can I take this with my blood pressure medication?
Hesperidin in this product may lower blood pressure further and theoretically increase the risk of low blood pressure. Check with your pharmacist before starting — they can review your specific medication and dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Joint Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Joint Support label
Go deeper

The Full Monographs Behind Pure Joint Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hesperidin

Interacts with 702 drugs

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...

Read the full Hesperidin monograph →
Sources

Sources & How We Checked

Pure Joint Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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