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Dietary supplement

Saccharomyces Boulardii plus MOS Ingredients & Drug Interactions

by Jarrow Formulas

Saccharomyces Boulardii plus MOS label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saccharomyces Boulardii plus MOS against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Saccharomyces Boulardii plus MOS is a dietary supplement by Jarrow Formulas with 2 active ingredients. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Saccharomyces boulardii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Saccharomyces Boulardii plus MOS by Jarrow Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Saccharomyces Boulardii plus MOS by Jarrow Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Saccharomyces Boulardii plus MOS by Jarrow Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.

This product contains two active ingredients: Saccharomyces boulardii, a beneficial yeast strain, and Bio-MOS, a prebiotic compound. Saccharomyces boulardii is designed to support digestive health by maintaining healthy gut flora, particularly in situations where diarrhea or digestive upset occurs.

The product also includes inactive ingredients—tapioca starch, silicon dioxide, vitamin C, and a capsule material called DRCaps—that help deliver the active components.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: probiotic support for intestinal tract health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Crohn disease, Irritable bowel syndrome (IBS), Rotaviral diarrhea, Travelers' diarrhea — and 3 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Saccharomyces Boulardii is rated "Insufficient Reliable Evidence To Rate" for Crohn disease, Ulcerative colitis, Irritable bowel syndrome (IBS).

Saccharomyces boulardii is possibly effective for several types of diarrhea: rotavirus-related diarrhea, travelers' diarrhea, antibiotic-associated diarrhea, and infection with Clostridioides difficile. It's also possibly effective for two other gastrointestinal conditions: necrotizing enterocolitis (NEC) in infants and Helicobacter pylori infection.

The evidence we hold does not establish Bio-MOS's effectiveness for any condition.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saccharomyces boulardii is generally well tolerated in healthy adults. However, the safety data advises against use if you're critically ill or have a weakened immune system—there's a rare but documented risk of the yeast entering the bloodstream (fungemia) in these populations, especially in intensive care settings or if you have central catheters.

A small number of people have reported gastrointestinal complaints like abdominal cramps, flatulence, nausea, vomiting, or decreased appetite. There isn't enough data on file for Bio-MOS to know its safety profile.

Pregnancy and lactation safety data for this product isn't on file—talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antifungal medications are the main concern. Because Saccharomyces boulardii is a live yeast, antifungals could reduce how well this supplement works.

Use the search tool on this page to check your specific antifungal drug, then ask your pharmacist whether you should take them at different times or hold the supplement while you're on antifungal treatment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This supplement is worth considering if you have diarrhea from antibiotics, travel, or rotavirus and you're otherwise healthy with a normal immune system. Skip it if you're critically ill or immunocompromised.

Before you start, check with your pharmacist or doctor, especially if you take antifungal medications—timing your doses matters.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saccharomyces Boulardii plus MOS, straight from the product label.

Brand Jarrow Formulas
Barcode (UPC) 790011030270
Net contents 30 Delayed Release Veggie Cap(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 243540
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saccharomyces Boulardii plus MOS by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
790011030270
IngredientAmount% DV
Bio-MOS200 mg--
Saccharomyces boulardii0 NP--

Other ingredients: Tapioca Starch, Silicon Dioxide, Vitamin C, DRCaps

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

No refrigeration necessary

Saccharomyces Boulardii+MOS does not require refrigeration and can be stored at room temperature. Refrigeration will, however, extend the shelf life. Avoid temperatures above 77 degrees F (25 degrees C).

General Statements

Travel friendly Blister cards

33+ probiotic pioneer since 1986

Formulation

Probiotic + Prebiotic Enhanced support for the intestinal tract

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.

Strains Matter When it comes to effective probiotics, clinically documented

Note: Capsule fill content may change, due to raw material particle size. However, potency remains the same.

Suitable for vegetarians/vegans.

Formula

5 billion live yeast cells guaranteed Clinically documented probiotic yeast

1 probiotic yeast strain

Saccharomyces Boulardii+MOS contains the probiotic yeast Saccharomyces boulardii, which survives passage through stomach acid and delivers its benefits to the intestinal tract. This strain helps protect and maintain a normal intestinal microflora. It also works to restore the normal intestinal microflora when possible disruptions may occur, such as during travel or the intake of certain medications. MOS (MannanOligoSaccharides) is an oligosaccharide from the cell walls of S. cerevisiae that can discourage bacteria from adhering to the epithelial cells and reduce their proliferation.

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Usage: Take 1 vegetarian capsule 1 or 2 times per day with water. Or take as directed by your qualified healthcare professional. May be taken with food or on an empty stomach.

Precautions

Note: For immune-compromised individuals and children, please consult your healthcare professional before using this product.

Note: For immune-compromised individuals and children, please consult your healthcare professional before using this product.

Keep out of the reach of children.

Brand IP Statement(s)

Bio-MOS is a registered trademark of Alltech. DRcaps & logo are trademarks of Lonza or its affiliates.

2020 Jarrow Formulas

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

V Vegan Veggie cap

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Saccharomyces Boulardii plus MOS by Jarrow Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saccharomyces Boulardii plus MOS label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saccharomyces Boulardii plus MOS by Jarrow Formulas

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bio-MOS

200 mg per serving Form: MOS, S. cerevisiae

Saccharomyces boulardii

Interacts with
40 drugs
0 NP per serving Form: S. cerevisiae strain

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii monograph & interactions

Other (inactive) ingredients: Tapioca Starch, Silicon Dioxide, Vitamin C, DRCaps. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saccharomyces Boulardii plus MOS by Jarrow Formulas Drug Interactions

Want to check YOUR meds against Saccharomyces Boulardii plus MOS?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

Saccharomyces boulardii 40

Individual Drug Interactions

The ingredients in Saccharomyces Boulardii plus MOS interact with 40 drugs. Click any drug to see the details.

1 of the 2 ingredients in Saccharomyces Boulardii plus MOS interact with drugs. Each result below shows which ingredient is responsible. Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in Saccharomyces Boulardii plus MOS with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saccharomyces Boulardii plus MOS, from the product label.

Jarrow Formulas

See all Jarrow Formulas products
Name
Jarrow Formulas Superior Nutrition and Formulation
City
Los Angeles
State
CA
ZipCode
90035-4317
Phone Number
(866) 459-4154
Web Address
www.jarrow.com
Pharmacist Counseling Corner

Saccharomyces Boulardii plus MOS by Jarrow Formulas: Common Questions

Does Saccharomyces Boulardii plus MOS by Jarrow Formulas interact with any medications?
Yes. Based on its ingredients, Saccharomyces Boulardii plus MOS has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saccharomyces Boulardii plus MOS contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Saccharomyces boulardii, and what does it do?
It's a live beneficial yeast that supports digestive health. The evidence shows it's possibly effective for several types of diarrhea—including diarrhea caused by antibiotics, travel, rotavirus, and Clostridioides difficile infection—as well as for necrotizing enterocolitis and Helicobacter pylori infection.
Can I take this if I'm on an antifungal medication?
Not without checking first. Antifungals can kill the live yeast in this supplement, making it less effective. Talk with your pharmacist about your specific antifungal—you may need to space them apart or pause the supplement while you're on treatment.
Is this safe if I have a weakened immune system?
No. The safety data advises against this product if you're immunocompromised or critically ill. There's a rare but documented risk that the live yeast could enter your bloodstream, especially in intensive care settings. Talk with your doctor before use.
What side effects might I notice?
Most people don't have problems. Rarely, people report stomach cramps, gas, nausea, vomiting, or loss of appetite. Very rarely, the yeast has caused a bloodstream infection, but that's been documented mainly in critically ill patients.
Is it safe to take this while pregnant or breastfeeding?
We don't have enough safety data for pregnancy or lactation on file for this product. Talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding.
What's Bio-MOS, and does it interact with anything?
Bio-MOS is a prebiotic ingredient in this formula. We don't have interaction data for it, so we can't tell you whether it interacts with medications. Ask your pharmacist if you want to know more about it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Saccharomyces Boulardii plus MOS is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saccharomyces Boulardii plus MOS label
Go deeper

The Full Monographs Behind Saccharomyces Boulardii plus MOS’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

Saccharomyces Boulardii plus MOS's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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