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Dietary supplement

Sheep Sorrel Ingredients & Drug Interactions

by Pure Herbs

Sheep Sorrel label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sheep Sorrel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sheep Sorrel is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for sinus and respiratory congestion, digestive upset, fever.Based on those ingredients, 169 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sheep Sorrel aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sheep Sorrel by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Sheep Sorrel by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sheep Sorrel by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Herbs Sheep Sorrel is a one-ingredient liquid supplement made from sheep sorrel aerial parts extract. That's the leaves, stems, and flowers of the plant.

There are no other active ingredients, and no inactive fillers are listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sorrel product and its label doesn't state a use — see Sorrel's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for sheep sorrel isn't established yet. We hold data on three uses — bronchitis, breast cancer, and rhinosinusitis (inflamed sinuses) — and for all of them the evidence is insufficient to make a rating.

That means studies either haven't been done, are too small to trust, or are mixed. Right now we can't say whether this product works for any of these conditions.

The evidence, ingredient by ingredient Sorrel

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sorrel is generally well tolerated in food amounts, but the concentrated form in this supplement raises two concerns. Sorrel is high in oxalates, compounds that can build up in your kidneys and cause damage, especially with large or concentrated doses.

There's a documented case of a 12-year-old who developed kidney inflammation after consuming wild sorrel. Also, if you're allergic to weed pollen, you have a small chance (up to 19%) of reacting to sorrel pollen — you might get allergic rhinitis or bronchial asthma.

When taken with other herbs, sorrel has caused nausea and an unpleasant aftertaste in some people. For pregnancy and breastfeeding, the safety rating is Possibly Safe, meaning there isn't enough data to know for sure.

The data advises against concentrated medicinal amounts while breastfeeding. If you're pregnant or nursing and want to use this, talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Sorrel

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sorrel.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 169 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take any blood thinners or antiplatelet drugs (like warfarin, apixaban, or aspirin) — sorrel may add to their effects. Also flag any drugs transported by OATP proteins, including the allergy medication fexofenadine.

Use the search tool on this page to look up your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sheep sorrel might interest someone looking into traditional herbal remedies, but the evidence that it works for any condition isn't solid yet. If you take blood thinners, allergy medications, or any drug moved by OATP proteins, you'll want to check with us first.

If you have a history of kidney problems or weed pollen allergies, be cautious. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sheep Sorrel, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279848
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sheep Sorrel by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
60
IngredientAmount% DV
Sheep Sorrel aerial parts extract1841 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for overall good health.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sheep Sorrel by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sheep Sorrel label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sheep Sorrel by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Sheep Sorrel aerial parts extract

Interacts with
169 drugs
1841 mg per serving

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for an...

Sheep Sorrel aerial parts extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sheep Sorrel by Pure Herbs Drug Interactions

Want to check YOUR meds against Sheep Sorrel?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
169Drugs
169 Moderate

Ingredients driving the most interactions

Sheep Sorrel aerial parts extract 169

Individual Drug Interactions

The ingredients in Sheep Sorrel interact with 169 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sheep Sorrel interact with drugs. Each result below shows which ingredient is responsible. Sheep Sorrel aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sheep Sorrel with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sheep Sorrel aerial parts extract3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Sheep Sorrel aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sheep Sorrel, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Sheep Sorrel by Pure Herbs: Common Questions

Does Sheep Sorrel by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Sheep Sorrel has a known interaction with 169 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sheep Sorrel contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does sheep sorrel actually work for anything?
We don't have enough reliable evidence yet to say whether it works for bronchitis, breast cancer, or sinus inflammation — the three uses we've reviewed. That doesn't mean it doesn't; it just means the studies aren't there or aren't strong enough to trust.
Is it safe to take if I have kidney problems?
Sorrel is high in oxalates, which can damage your kidneys, especially in concentrated doses like this supplement. If you have any kidney issues, talk to your doctor or pharmacist before using it.
Can I take this while pregnant or breastfeeding?
The safety data for pregnancy is Possibly Safe, meaning there isn't enough information to say for sure. During breastfeeding, the data advises against concentrated medicinal amounts. Either way, talk with your doctor or pharmacist — this is a personal decision that depends on your situation.
What are the side effects I should watch for?
If you're allergic to weed pollen, you might have an allergic reaction — allergic rhinitis or asthma symptoms. Nausea and an unpleasant aftertaste have been reported when sorrel is used with other herbs. High doses can stress your kidneys.
Does this product have fillers or other inactive ingredients?
No — it's a pure extract with no other inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sheep Sorrel is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sheep Sorrel label
Go deeper

The Full Monographs Behind Sheep Sorrel’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph →
Sources

Sources & How We Checked

Sheep Sorrel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sorrel 8 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

See these in context on the Sorrel monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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